Analysis of osteoclast precursor niche regulated by BM-MSC
| Project/Area Number |
26462826
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小林 泰浩 松本歯科大学, 総合歯科医学研究所, 教授 (20264252)
中道 裕子 松本歯科大学, 総合歯科医学研究所, 講師 (20350829)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 破骨細胞 / 破骨細胞前駆細胞 / ニッチ / 間葉系幹細胞 / 骨芽細胞 / Runx2 / Osterix / レプチン受容体 / 骨髄間葉系幹細胞 / PTH / ＱＯＰ / M-CSF / osteoprotegerin / c-Fms / 細胞周期 / QOP |
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| Outline of Final Research Achievements |
Previously, we identified an in vivo osteoclast precursor (QOP: quiescent osteoclast precursor). We hypothesized that the QOP are regulated by bone marrow mesenchymal stem cells (BM-MSC), and analyzed in vivo behavior of BM-MSC. In the present study, we revealed following things: (1) BM-MSC (LepR+ cells) express Runx2 (LepR+Runx2low cells). (2) In response to parathyroid hormone (PTH), LepR+Runx2low cells differentiate into osteoblasts via milt-layered cell formation. (3) The multi-layered cells express Osterix and Type I collagen sequentially, and eventually differentiate into mature osteoblasts.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Self renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance.2016
Author(s)
Ito K, Turcotte R, Cui J, Zimmerman SE, Pinho S, Mizoguchi T, Arai F, Runnels JM, Alt C, Teruya-Feldstein J, Mar JC, Singh R, inkel T, Suda T, Lin CP, Frenette PS, Ito K
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Journal Title
Science
Volume: 354(6316)
Issue: 6316
Pages: 1156-1160
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Comparing immunocompetent and immunodeficient mice as ectopic transplantation animal models for bone tissue engineering2015
Author(s)
Zhang Y, Li X, Chihara T, Mizoguchi T, Hori A, Udagawa N, Takahashi N, Nakamura H, Hasegawa H, Taguchi A, Shinohara A, Kagami H
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Journal Title
Oral Diseases
Volume: 21
Issue: 5
Pages: 583-592
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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