| Project/Area Number |
26462826
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小林 泰浩 松本歯科大学, 総合歯科医学研究所, 教授 (20264252)
中道 裕子 松本歯科大学, 総合歯科医学研究所, 講師 (20350829)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 破骨細胞 / 破骨細胞前駆細胞 / ニッチ / 間葉系幹細胞 / 骨芽細胞 / Runx2 / Osterix / レプチン受容体 / 骨髄間葉系幹細胞 / PTH / ＱＯＰ / M-CSF / osteoprotegerin / c-Fms / 細胞周期 / QOP |
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| Outline of Final Research Achievements |
Previously, we identified an in vivo osteoclast precursor (QOP: quiescent osteoclast precursor). We hypothesized that the QOP are regulated by bone marrow mesenchymal stem cells (BM-MSC), and analyzed in vivo behavior of BM-MSC. In the present study, we revealed following things: (1) BM-MSC (LepR+ cells) express Runx2 (LepR+Runx2low cells). (2) In response to parathyroid hormone (PTH), LepR+Runx2low cells differentiate into osteoblasts via milt-layered cell formation. (3) The multi-layered cells express Osterix and Type I collagen sequentially, and eventually differentiate into mature osteoblasts.
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