• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Challenge of raiditoherapy for oral cancer -definition of appropriate combination both cetuximab and docetaxel-

Research Project

Project/Area Number 26462838
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionThe University of Tokushima

Principal Investigator

KUDOH Takaharu  徳島大学, 大学院医歯薬学研究部(歯学系), 助教 (10263865)

Co-Investigator(Kenkyū-buntansha) 生島 仁史  徳島大学, 大学院医歯薬学研究部(医学系), 教授 (90202861)
宮本 洋二  徳島大学, 大学院医歯薬学研究部(歯学系), 教授 (20200214)
玉谷 哲也  徳島大学, 病院, 講師 (30274236)
工藤 景子  徳島大学, 大学院医歯薬学研究部(歯学系), 助教 (70380029)
高橋 章  徳島大学, 病院, 講師 (30252688)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords癌 / 細胞実験 / 放射線照射 / ドセタキセル / セツキシマブ
Outline of Final Research Achievements

Before, during and after irradiation, determine an appropriate combinaton both cetuximab and docetaxel in vitro using analyses of colony formation assay and apoptosis. First, in vitro experiment to B88 cell and CAL27 cell. In the analysis, it became clear that 4 Gy was an appropriate dose and docetaxel was 4 ng/ml, cetuximab was 25 microg/ml in 2 hour processing. The significant difference was not accepted even if it prescribed docetaxel or cetuximab for each period of irradiation. There is a mission which determines an appropriate combination by other medicines and irradiation in vitro and vivo from now on, and determines the regimen of the optimal organ preservation treatment.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2017 2016

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (6 results)

  • [Journal Article] Effectiveness of Newly Developed Water-Equivalent Mouthpiece during External Beam Radiation for Oral Cancer2017

    • Author(s)
      Kudoh T, Ikushima H, Kudoh K, Furutani S, Kawanaka T, Kubo A, Takamar N, Tamatani T and Miyamoto Y
    • Journal Title

      Annals of Carcinogenesis

      Volume: 2 Pages: 1-5

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A case of tophaceous pseudogout of the temporomandibular joint extending to the base of the skull2017

    • Author(s)
      Keiko Kudoh, Takaharu Kudoh and Youji Miyamoto
    • Journal Title

      International Journal of Oral and Maxillofacial Surgery

      Volume: 46 Issue: 3 Pages: 355-359

    • DOI

      10.1016/j.ijom.2016.08.018

    • NAID

      120006501913

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence and imaging characteristics of palatine tonsilloliths evaluated on 2244 pairs of panoramic radiographs and CT images2016

    • Author(s)
      Akira Takahashi, Chieko Sugawara, Takaharu Kudoh, Go Ohe, Natsumi Takamaru, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto
    • Journal Title

      Clinical Oral Investigations

      Volume: 21-1 Issue: 1 Pages: 85-91

    • DOI

      10.1007/s00784-016-1752-0

    • NAID

      120006714438

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 口腔がん患者の歯科疾患罹患状況2016

    • Author(s)
      山村 佳子, 藤澤 健司, 鎌田 久美子, 髙丸 菜都美, 工藤 景子, 大江 剛, 工藤 隆治, 高橋 章, 玉谷 哲也, 永井 宏和, 宮本 洋二
    • Journal Title

      日本歯科人間ドック学会誌

      Volume: 11 Pages: 29-32

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] 頭頸部癌に対するIMRTの予防的頸部CTV設定の妥当性の検証2016

    • Author(s)
      工藤 隆治, 久保 亜貴子, 川中 崇, 古谷 俊介, 生島 仁史
    • Organizer
      日本放射線腫瘍学会第29回学術大会
    • Place of Presentation
      京都国際会議場(京都府京都市)
    • Year and Date
      2016-11-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 当科における早期口腔扁平上皮癌患者の臨床的検討2016

    • Author(s)
      玉谷 哲也, 髙丸 菜都美, 鎌田 久美子, 横田 美保, 山村 佳子, 工藤 景子, 大江 剛, 工藤 隆治, 高橋 章, 藤澤 健司, 永井 宏和, 宮本 洋二
    • Organizer
      第64回NPO法人日本口腔科学会中国・四国地方部会
    • Place of Presentation
      国際ホテル宇部(山口県宇部市)
    • Year and Date
      2016-10-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] 口腔扁平上皮癌の頸部リンパ節転移診断におけるFDG-PET検査の有用性2016

    • Author(s)
      高橋 章, 鎌田 久美子, 山村 佳子, 髙丸 菜都美, 工藤 隆治, 工藤 景子, 大江 剛, 藤澤 健司, 玉谷 哲也, 永井 宏和, 宮本 洋二
    • Organizer
      第15回中国四国口腔癌研究会
    • Place of Presentation
      国際ホテル宇部(山口県宇部市)
    • Year and Date
      2016-10-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] 口腔癌に対する強度変調放射線治療の有効性について2016

    • Author(s)
      工藤 隆治, 工藤 景子, 高橋 章, 宮本 洋二
    • Organizer
      NPO法人日本歯科放射線学会 第57回学術大会・第13回定例総会
    • Place of Presentation
      グランキューブ大阪(大阪府大阪市)
    • Year and Date
      2016-06-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] 硬口蓋を基準とした後上歯槽動脈の走行に関する検討2016

    • Author(s)
      高橋 章, 工藤 隆治, 工藤 景子, 髙丸 菜都美, 大江 剛, 玉谷 哲也, 永井 宏和, 藤澤 健司, 宮本 洋二
    • Organizer
      第70回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2016-04-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 当科における口腔がん検診の現況2016

    • Author(s)
      工藤 景子, 鎌田 久美子, 横田 美保, 髙丸 菜都美, 山村 佳子, 大江 剛, 工藤 隆治, 高橋 章, 玉谷 哲也, 藤澤 健司, 永井 宏和, 宮本 洋二
    • Organizer
      日本歯科人間ドック学会第19回学術大会
    • Place of Presentation
      徳島大学(徳島県徳島市)
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi