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Application of an in-vivo portable EPR dosimetry against radiation exposures

Research Project

Project/Area Number 26462841
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionKagawa University

Principal Investigator

Miyake Minoru  香川大学, 医学部, 教授 (20239370)

Co-Investigator(Kenkyū-buntansha) 松井 義郎  香川大学, 医学部, 教授 (10181687)
岩崎 昭憲  香川大学, 医学部附属病院, 助教 (10437676)
山口 一郎  国立保健医療科学院, その他部局等, 上席主任研究官 (50311395)
平田 拓  北海道大学, 情報科学研究科, 教授 (60250958)
欅田 尚樹  国立保健医療科学院, その他部局等, 部長 (90178020)
Co-Investigator(Renkei-kenkyūsha) HIRATA Hiroshi  北海道大学, 情報科学研究科, 教授 (60250958)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
KeywordsポータブルEPR / 歯エナメル質 / 福島 / 被ばく線量測定 / 生体計測 / ポータブル装置 / 被ばく線量計測 / EPR / エナメル質
Outline of Final Research Achievements

We conducted experiments regarding to the equipment for practical usage of EPR portable spectrometer, and also evaluated measurements with volunteers, and analyzed the detection limit of this device. 34 volunteers in Fukushima prefecture participated the practical measurements. As the results, ratio of EPR signal intensity versus standard signal intensity with PDT was 0.087±0.051. The intensity of the signals that were obtained were not significantly above those seen in volunteers. The detection limits for radiation exposures are calculated. The sensitivities are 77.0%, 99.9% and specificities are 78.0%, 99.8% with 1Gy, 2Gy exposures respectively under ex-vivo condition. We demonstrated that it is feasible to transport the dosimeter to the site and make valid measurements as a triage purposes with high dose (>2-4Gy).

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (22 results)

All 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Acknowledgement Compliant: 2 results) Presentation (13 results) (of which Int'l Joint Research: 7 results) Remarks (3 results)

  • [Int'l Joint Research] Dartmouth EPR Center(米国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] In vivo radiation dosimetry using portable L-band EPR : On-site measurement of volunteers in Fukushima Prefecture, Japan2016

    • Author(s)
      Miyake M., Nakai Y., Yamaguchi I., Hirata H., Kunugita N., Williams BB., Harold MS.
    • Journal Title

      Radiation Protection Dosimetry

      Volume: 173 Issue: 1-3 Pages: 248-253

    • DOI

      10.1093/rpd/ncw214

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] L-Band EPR tooth dosimetry for heavy ion irradiation2016

    • Author(s)
      Yamaguchi I, Sato H, Kawamura H, Hamano T, Yoshii H, Suda M., Miyake M., Kunugita N.
    • Journal Title

      Radiation Protection Dosimetry

      Volume: 173 Issue: 1-3 Pages: 81-86

    • DOI

      10.1093/rpd/ncw236

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The utility of bone scintigraphy in the assessment of mandibular metabolism during long-term bisphosphonate administration2016

    • Author(s)
      Ohbayashi Y., Nakai F, Iwasaki A., Ogawa T., Yamamoto Y., Nishiyama Y., Miyake M.
    • Journal Title

      Odontology

      Volume: - Issue: 3 Pages: 382-390

    • DOI

      10.1007/s10266-016-0279-9

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel blood-brain-barrier-permeable spin probe for in vivo electron paramagnetic resonance imaging2016

    • Author(s)
      X. Wang, M. Emoto, Y. Miyake, K. Itto, S. Xu, H. Fujii, H. Hirata, H. Arimoto,
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 26 Issue: 20 Pages: 4947-4949

    • DOI

      10.1016/j.bmcl.2016.09.010

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 放射性物質テロへの公衆衛生対応2016

    • Author(s)
      山口一郎
    • Journal Title

      保健医療科学

      Volume: 65(6) Pages: 569-575

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] 緊急被ばく医療が必要とされるような事故発生時におけるトリアージのための線量評価手法の検討2016

    • Author(s)
      4)欅田 尚樹、山口 一郎、志村 勉、三宅 実、中村 麻子、盛武 敬
    • Organizer
      第89回日本産業衛生学会
    • Place of Presentation
      福島
    • Year and Date
      2016-05-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] In-vivo tooth dosimetry using L band EPR - The research involving human subjects related to Fukushima nuclear power plant accident-2016

    • Author(s)
      Minoru Miyake , IchiroYamaguchi, Yasuhiro Nakai, Hiroshi Hirata, Naoki Kunugita and Harold M. Swartz
    • Organizer
      The 14th Congress of the International Radiation Protection Association
    • Place of Presentation
      ケープタウン、南アフリカ
    • Year and Date
      2016-05-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] L band EPR tooth dosimetry for high LET radiation2016

    • Author(s)
      1)Ichiro Yamaguchi, Hitoshi Sato, Hiraku Kawamura, Tuyoshi Hamano, Hiroshi Yoshii, Mituru Suda, Minoru Miyake and Naoki Kunugita
    • Organizer
      The 14th Congress of the International Radiation Protection Association
    • Place of Presentation
      ケープタウン、南アフリカ
    • Year and Date
      2016-05-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] L band EPR tooth dosimetry for high LET radiation.2016

    • Author(s)
      Ichiro Yamaguchi, Itsuki Sato, Hiroshi Kawamura, Tsuyoshi Hamano, Hiroshi Yoshii, Mitsuru Suda , Minoru Miyake and Naoki Kunugita
    • Organizer
      IRPA14
    • Place of Presentation
      Cape Town, South Africa
    • Year and Date
      2016-05-09
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] In-vivo tooth dosimetry using L band EPR- The research involving human subjects related to Fukushima nuclear power plant accident-2016

    • Author(s)
      Minoru Miyake, Ichiro Yamaguchi, Yasuhiro Nakai, Hiroshi Hirata, Naoki Kunugita, and Harold M. Swartz
    • Organizer
      IRPA14
    • Place of Presentation
      Cape Town, South Africa
    • Year and Date
      2016-05-09
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] ポータブル型生体EPR (Electron Paramagnetic Resonance:電子常磁性体共鳴法)を用いた放射線被ばく線量測定ー福島在住のボランティアからの計測―2016

    • Author(s)
      3)三宅 実、中井康博、山口一郎、岩崎昭憲、中井 史、小川尊明、大林由 美子、欅田尚樹
    • Organizer
      第70回 NPO法人日本口腔科学会学術集会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2016-04-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] ポータブル型生体EPR (Electron Paramagnetic Resonance:電子常磁性体共鳴法)を用いた放射線被ばく線量測定ー福島在住のボランティアからの計測―2016

    • Author(s)
      三宅 実、中井康博、山口一郎、岩崎昭憲、中井 史、小川尊明、大林由美子、欅田尚樹*
    • Organizer
      第70回NPO法人日本口腔科学会総会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2016-04-15
    • Related Report
      2015 Research-status Report
  • [Presentation] 歯を用いたL-bandEPRによる線量推定法の基礎的な検討2015

    • Author(s)
      山口一郎、佐藤斉、川村拓、濱野毅、須田充、吉井裕、三宅 実、中井康博、平田拓、欅田尚樹
    • Organizer
      第14回日本放射線安全管理学会
    • Place of Presentation
      茨城、筑波大学キャンパス
    • Year and Date
      2015-12-02
    • Related Report
      2015 Research-status Report
  • [Presentation] Comparison of Noise in EPR Measurement Due to Different Environmental Conditions2015

    • Author(s)
      Yasuhiro Nakai, Minoru Miyake, Ichiro Yamaguchi, Hiroshi Hirata, Naoki Kunugita, Benjamin Williams and Harold M. Swartz
    • Organizer
      EPR BioDose 2015
    • Place of Presentation
      Hanover, New Hampshire, USA
    • Year and Date
      2015-10-04
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] In-vivo radiation dosimetry using portable L band EPR -On-site measurement of volunteers in FUKUSHIMA Prefecture, Japan2015

    • Author(s)
      Minoru Miyake, Yasuhiro Nakai, Ichiro Yamaguchi, Hiroshi Hirata, Naoki Kunugita, Benjamin Williams and Harold M.Swartz
    • Organizer
      EPR BioDose 2015
    • Place of Presentation
      Hanover, New Hampshire, USA
    • Year and Date
      2015-10-04
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] L BAND EPR TOOTH DOSIMETRY FOR HEAVY ION IRRADIATION2015

    • Author(s)
      Ichiro Yamaguchi, Itsuki Sato, Hiroshi Kawamura, Tsuyoshi Hamano, Hiroshi Yoshii, Mitsuru Suda , Minoru. Miyake and Naoki Kunugita
    • Organizer
      EPR BioDose 2015
    • Place of Presentation
      Hanover, New Hampshire, USA
    • Year and Date
      2015-10-04
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 歯を用いたL-band EPRによる線量推計法の開発2015

    • Author(s)
      山口一郎, 佐藤斉, 川村拓,濱野毅,須田充,吉井裕,三宅実,中井康博,平田拓,欅田尚樹
    • Organizer
      日本保健物理学会
    • Place of Presentation
      首都大学東京 荒川キャンパス
    • Year and Date
      2015-07-02 – 2015-07-03
    • Related Report
      2014 Research-status Report
  • [Presentation] 歯を用いたL-bandEPRによる線量推定法の開発2015

    • Author(s)
      山口一郎、佐藤斉、川村拓、濱野毅、須田充、吉井裕、三宅 実、中井康博、平田拓、欅田尚樹
    • Organizer
      第48回日本保健物理学会研究会発表会
    • Place of Presentation
      首都大学東京荒川キャンパス
    • Year and Date
      2015-07-02
    • Related Report
      2015 Research-status Report
  • [Remarks] 香川大学医学部歯科口腔外科学教室研究活動

    • URL

      http://www.kms.ac.jp/~dent/research/page03.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] EPR線量測定研究成果

    • URL

      http://trustrad.sixcore.jp/invivo_EPR/

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
  • [Remarks] EPR線量測定研究成果

    • URL

      http://trustrad.sixcore.jp/invivo_EPR/background.html

    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2022-01-27  

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