Approach to osseointegration based on the cytoskeletal regulation by implant
| Project/Area Number |
26462924
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Prosthodontics/ Dental materials science and
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
熱田 生 九州大学, 大学病院, 助教 (30423487)
古谷野 潔 九州大学, 歯学研究院, 教授 (50195872)
鮎川 保則 九州大学, 大学病院, 講師 (50304697)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | インプラント / 表面形状 / 細胞骨格 / 表面性状 |
|---|
| Outline of Final Research Achievements |
Cytoskeletal regulation and its related-cellular functions by implant surface topography (Smooth (S), Micron (M) and Nano (N) surfaces) were investigated. S-adherent cells exhibited cell spreading and M- and N-adherent cells had longer ans thinner projections. RhoA, a cytoskeletal regulatory factor, was activated in order of surface roughness. Longer and thinner projections were induced by RhoA inhibitor on all surfaces. Although RhoA inhibitor altered cellular functions (adhesion, migration and differentiation into osteoblast) on S surface, these were limited on M and N surface. These findings suggest regulation of cellular functions by surface topography is associated with cytoskeletal regulation.
|
Report
(4 results)
Research Products
(5 results)
