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Approach to osseointegration based on the cytoskeletal regulation by implant

Research Project

Project/Area Number 26462924
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Prosthodontics/ Dental materials science and
Research InstitutionKyushu University

Principal Investigator

Ogino Yoichiro  九州大学, 歯学研究院, 助教 (50380431)

Co-Investigator(Kenkyū-buntansha) 熱田 生  九州大学, 大学病院, 助教 (30423487)
古谷野 潔  九州大学, 歯学研究院, 教授 (50195872)
鮎川 保則  九州大学, 大学病院, 講師 (50304697)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsインプラント / 表面形状 / 細胞骨格 / 表面性状
Outline of Final Research Achievements

Cytoskeletal regulation and its related-cellular functions by implant surface topography (Smooth (S), Micron (M) and Nano (N) surfaces) were investigated. S-adherent cells exhibited cell spreading and M- and N-adherent cells had longer ans thinner projections. RhoA, a cytoskeletal regulatory factor, was activated in order of surface roughness. Longer and thinner projections were induced by RhoA inhibitor on all surfaces. Although RhoA inhibitor altered cellular functions (adhesion, migration and differentiation into osteoblast) on S surface, these were limited on M and N surface. These findings suggest regulation of cellular functions by surface topography is associated with cytoskeletal regulation.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2016 2014 Other

All Int'l Joint Research (1 results) Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results) Presentation (3 results)

  • [Int'l Joint Research] ミシガン大学/ノースカロライナ大学チャペルヒル校(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] RhoA-Mediated Functions in C3H10T1/2 Osteoprogenitors Are Substrate Topography Dependent.2016

    • Author(s)
      Ogino Y, Liang R, Mendonca DB, Mendonca G, Nagasawa M, Koyano K, Cooper LF.
    • Journal Title

      J Cell Physiol.

      Volume: 231 Issue: 3 Pages: 568-575

    • DOI

      10.1002/jcp.25100

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] インプラント表面形状依存性の細胞骨格形成因子RhoAが骨分化能におよぼす影響2016

    • Author(s)
      荻野洋一郎,長澤麻沙子,古谷野潔
    • Organizer
      公益社団法人日本補綴歯科学会第125回学術大会
    • Place of Presentation
      石川県金沢市
    • Year and Date
      2016-07-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] Topography influences cellular responses and RhoA activity of titanium surface-adherent cells.2014

    • Author(s)
      Yoichiro Ogino, Lyndon F. Cooper、 Kiyoshi Koyano
    • Organizer
      Congress of Asian Academy of Prosthodontincs
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2014-11-21 – 2014-11-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Topography influences cellular functions and RhoA activity of titanium surface-adherent cells.2014

    • Author(s)
      Yoichiro Ogino, Lyndon F. Cooper、 Kiyoshi Koyano
    • Organizer
      9th International Wrokshop on Biomaterials in Interface Science
    • Place of Presentation
      Miyagi, Japan
    • Year and Date
      2014-08-26 – 2014-08-27
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2022-02-16  

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