Development of photofunctionalized zirconia implant

• Project/Area Number: 26462937
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Showa University
• Principal Investigator: Iwasa Fuminori 昭和大学, 歯学部, 准教授 (60297025)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: インプラント / ジルコニア / 紫外線 / ナノジルコニア / UV

Outline of Final Research Achievements

We aimed to develop a zirconium (Ce-TZP) implant fixture functionalized by ultraviolet (UV). Ce-TZP/Al2O3 treated with hydrofluoric acid (HF) irradiated by UV with shifting the wavelength and the irradiation time. The adhesion, proliferation, differentiation, and expression of bone related genes of osteoblastic cell (MC3T3-E1) on these samples enhanced by 15-40% under the wavelength and time of a specific pattern. Similarly, osseointegration capability on UV functionalized Ce-TZP increased significantly compared to control group. Oxidant stress induced cell cytotoxicity by UV irradiation did not show deleterious effect on cellular level. We concluded about this matter that there is no our safety concern.

Research Products

• [Journal Article] Effect of Nanofeatured Topography on Ceria-Stabilized Zirconia/Alumina Nanocomposite on Osteogenesis and Osseointegration. (2017)
  • Author(s): Oshima Y, Iwasa F, Tachi K, Baba K
  • Journal Title: Int J Oral Maxillofac Implants Volume: 32(1) Pages: 81-91
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Enhanced intracellular signaling pathway in osteoblasts on ultraviolet light-treated hydrophilic titanium. (2016)
  • Author(s): Iwasa F, Baba K, Ogawa T
  • Journal Title: Biomedical Research Volume: 37 Pages: 1-11
  • NAID: 130005128372
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Enhanced intracellular signaling pathway in osteoblasts on ultraviolet light-treated hydrophilic titanium (2016)
  • Author(s): Fuminori Iwasa
  • Journal Title: Biomedical Research Volume: 37(1) Pages: 1-11
  • NAID: 130005128372
  • Peer Reviewed
• [Presentation] Enhanced osseointegration on hydrofluoric-acid treated ceria-stabilised zirconia/alumina nanocomposite. (2016)
  • Author(s): Iwasa F
  • Organizer: 25 th annual scientific meeting of the European association for osseointegration congress, Paris
  • Place of Presentation: Paris, France
  • Year and Date: 2016-09-29
  • Int'l Joint Research