Bone augmentation using 3D oriented collagen scaffold

• Project/Area Number: 26462979
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Nihon University
• Principal Investigator: IKEDA Takayuki 日本大学, 歯学部, 講師 (30366603)
• Co-Investigator(Kenkyū-buntansha): 祇園白 信仁 日本大学, 歯学部, 教授 (90153262) ; 本田 雅規 愛知学院大学, 歯学部, 教授 (70361623) ; 成田 達哉 日本大学, 歯学部, 助教 (50508629)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 三次元配向性コラーゲン / 骨増生 / 骨造成 / コラーゲンマテリアル / 垂直的骨造成 / 配向性コラーゲン / 3Dコラーゲンマテリアル

Outline of Final Research Achievements

Simple and reliably vertical bone augmentation of alveolar bone is desired for enduring achievement of dental implant treatment.This study examined the effects of vertical bone augmentation using 3D oriented collagen scaffold in vitro and in vivo.3D oriented collagen scaffold had adequate strength as no morphology alteration was observed in culture medium and rat blood. The number of attached cells was significantly greater on 3D oriented collagen scaffold. micro-CT showed a difference in ossification ratio between the controls and the 3D oriented collagen scaffold group.

Research Products

• [Presentation] Vertical bone augmentation using 3D oriented collagen scaffold (2016)
  • Author(s): T.IKEDA, T.NARITA, Y.ISOBE, M.MARUNO, N.GIONHAKU, M.HONDA
  • Organizer: 第45回 AADR
  • Place of Presentation: Los Angeles(U.S.A)
  • Year and Date: 2016-03-16
  • Int'l Joint Research