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Development of novel cartilage regeneration method utilizing regenerative precursor cells and in vivo maturation promoting factor

Research Project

Project/Area Number 26462996
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionGunma University (2016)
The University of Tokyo (2014-2015)

Principal Investigator

KANNO Yuki  群馬大学, 医学部附属病院, 助教 (80451813)

Co-Investigator(Kenkyū-buntansha) 星 和人  東京大学, 医学部附属病院, 准教授 (30344451)
森 良之  自治医科大学, 医学部, 教授 (70251296)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords再生前駆細胞 / 成熟促進因子 / 再生軟骨 / 軟骨再生 / 培養軟骨細胞 / 分裂速度
Outline of Final Research Achievements

In this study, we identify regenerative precursor cells that constitute regenerative tissues in vivo, select them, clarify the cartilage maturation promoting factor in vivo, realize maturation before transplantation of cartilage regeneration tissue by utilizing both, It aimed to dramatically improve the characteristics of regenerated tissue. A PP plate seeded with cultured mouse chondrocytes for confirmation of the maturation promoting factor from the transplanting mother bed was transplanted into the abdominal cavity of a nude mouse. Ascites supernatant collected after transplantation and ascites cells were co-cultured with human chondrocytes and gene expression was evaluated. In the ascitic cell mRNA, the expression change was searched and the gene strongly inducing cartilage maturation was examined. For proteins in the ascites supernatant, analysis was performed to examine factors that promote cartilage maturation.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2016 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results)

  • [Journal Article] A 2-Stage Reconstruction of the Jaw Using Vascularized Bone and Secondary Alveolar Ridge Augmentation With Particulate Cancellous Bone and Marrow2016

    • Author(s)
      K. Ohkubo et al
    • Journal Title

      Implant Dent

      Volume: 25(2) Issue: 2 Pages: 302-6

    • DOI

      10.1097/id.0000000000000394

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 8.Kanno Y, Nakatsuka T, Saijo H, Fujihara Y, Atsuhiko H, Chung U, Takato T, Hoshi K.2016

    • Author(s)
      Kanno Y, Nakatsuka T, Saijo H, Fujihara Y, Atsuhiko H, Chung U, Takato T, Hoshi K.
    • Journal Title

      Computed tomographic evaluation of novel custom-made artificial bones, “CT-bone”, applied for maxillofacial reconstruction.

      Volume: 5 Pages: 1-8

    • DOI

      10.1016/j.reth.2016.05.002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 唇裂鼻2次修正に用いる再生軟骨 臨床研究と医師主導治験・企業治験の経験とその特徴2016

    • Author(s)
      星 和人、西條英人、藤原夕子、稲木涼子、杉山 円、菅野勇樹、末永英之、米永一理、小笠原徹、高戸 毅
    • Organizer
      第61回日本口腔外科学会総・学術大会
    • Place of Presentation
      幕張メッセ、千葉市、千葉県
    • Year and Date
      2016-11-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 口腔外科手術における自己フィブリン糊の使用2014

    • Author(s)
      菅野 勇樹
    • Organizer
      第62回日本輸血・細胞治療学会総会
    • Place of Presentation
      奈良県 新公会堂
    • Year and Date
      2014-05-14 – 2014-05-17
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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