Analysis of metastasis and Wnt signaling in oral cancer using cervical lymph node metastasis model
| Project/Area Number |
26463002
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
Iwai Soichi 大阪大学, 歯学部附属病院, 講師 (10362675)
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| Co-Investigator(Renkei-kenkyūsha) |
YURA Yoshiaki 大阪大学, 歯学研究科, 教授 (00136277)
NIKI Atsuko (YONEKAWA Atsuko) 大阪大学, 歯学部附属病院, 医員 (70600914)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 癌の浸潤・転移 / シグナル伝達 / Wnt シグナル / 口腔扁平上皮癌 / 浸潤能 / 高転移能株 / ウイントシグナル / 口腔扁平上皮癌細胞 / 転移能 |
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| Outline of Final Research Achievements |
It is very important for cancer therapy to analysis of tumor invasion and metasis.
We established highly lymph nodes metastatic cell line from oral squamous cell carcinoma (OSCC) cells after in vivo selection, and investigated the involvement of Wnt signaling in metastasis using those OSCC cells with different metastatic potential. We demonstrated that Wnt5b is involved in cell motility through the activation of Cdc42 and RhoA via the non-canonical Wnt signaling pathway, and the elevated expression of Wnt5b may become an important index for the evaluation of OSCC invasion and metastasis. Furthermore, Wnt5b may become a promising therapeutic target for the prevention of OSCC metastasis
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Report
(4 results)
Research Products
(4 results)
