Functional analysis of GSK3beta in human oral cancer stem cells
Project/Area Number |
26463005
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Surgical dentistry
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Research Institution | Hiroshima University |
Principal Investigator |
Shigeishi Hideo 広島大学, 医歯薬保健学研究院(歯), 助教 (90397943)
|
Co-Investigator(Kenkyū-buntansha) |
太田 耕司 広島大学, 病院(歯), 助教 (20335681)
小野 重弘 広島大学, 医歯薬保健学研究院(歯), 助教 (70379882)
東川 晃一郎 広島大学, 病院(歯), 講師 (80363084)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 口腔癌 / 癌幹細胞 / ALDH1 / GSK3β / ALDH1 |
Outline of Final Research Achievements |
CD44 and aldehyde dehydrogenase 1 (ALDH1) has been proved useful marker for the identification of cancer stem cells (CSCs). We previously reported that glycogen synthase kinase 3(GSK3beta) is involved in the regulation of self-renewal ability of oral squamous cell carcinoma (OSCC) CSC (Shigeishi et al. 2013). We demonstrate that GSK3beta play a major role in the maintenance of stemness of CD44high/ALDH1high HNSCC cells. Additionally, our results indicate a close relationship between CSC and mesenchymal character in OSCC.
|
Report
(4 results)
Research Products
(9 results)
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[Journal Article] CD44(high) /ALDH1(high) head and neck squamous cell carcinoma cells exhibit mesenchymal characteristics and GSK3β-dependent cancer stem cell properties.2016
Author(s)
Seino S, Shigeishi H, Hashikata M, Higashikawa K, Tobiume K, Uetsuki R, Ishida Y, Sasaki K, Naruse T, Rahman MZ, Ono S, Simasue H, Ohta K, Sugiyama M, Takechi M.
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Journal Title
J Oral Pathol Med
Volume: 45
Issue: 3
Pages: 180-188
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Snail-induced CD44high cells in HNSCC with high ABC transporter capacity exhibit potent resistance to cisplatin and docetaxel.2016
Author(s)
Hashikata M, Shigeishi H, Okui G, Yamamoto K, Tobiume K, Seino S, Uetsuki R, Kato H, Ishioka Y, Ono S, Ohta K, Higashikawa K, Sugiyama M, Takechi M.
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Journal Title
Int J Clin Exp Pathol
Volume: 9(8)
Pages: 7908-7918
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinicopathological analysis of salivary gland carcinomas and literature review.2015
Author(s)
Shigeishi H, Ohta K, Okui G, Seino S, Hashikata M, Yamamoto K, Ishida Y, Sasaki K, Naruse T, Rahman MZ, Uetsuki R, Nimiya A, Ono S, Shimasue H, Higashikawa K, Sugiyama M, Takechi M.
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Journal Title
Mol Clin Oncol
Volume: 3(1)
Pages: 202-206
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] CD44high/ALDH1high口腔扁平上皮癌細胞における癌幹細胞形質の解析2015
Author(s)
清野 紗矢香, 重石 英生, 奥井 岳, 箸方 美帆, 植月 亮, 山本 一博, 小野 重弘, 東川 晃一郎, 太田 耕司, 島末 洋, 武知 正晃.
Organizer
日本組織培養学会第88回大会
Place of Presentation
広島
Year and Date
2015-05-26
Related Report
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