Establishment of jaw bone reconstruction treatment using osteoblast/interconnected porous hydroxyapatite ceramics composite
| Project/Area Number |
26463009
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
masaaki takechi 広島大学, 医歯薬保健学研究院(歯), 准教授 (00304535)
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| Co-Investigator(Kenkyū-buntansha) |
太田 耕司 広島大学, 病院(歯), 助教 (20335681)
中川 貴之 広島大学, 病院(歯), 病院助教 (30456230)
小野 重弘 広島大学, 医歯薬保健学研究院(歯), 助教 (70379882)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ｂｏｎｅ / ｈｙｄｒｏｘｙａｐａｔｉｔｅ / メラトニン / ＦＧＦ / ハイドロキシアパタイト / 骨芽細胞 / 顎骨再建 |
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| Outline of Final Research Achievements |
We were able to establish the three-dimensional culture method of the most suitable human jaw bone of osteoblasts. In addition, as a result of making neobone that gave the jawbone form of dogs by CT image data, and having transplanted the complex with the cell after jaw bone area excision, good bone formation was observed in an experimental group in comparison with control group. Furthermostate，after implant placement,excellent osseointegration was provided in FGF-2 and the melatonin group.
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Report
(4 results)
Research Products
(6 results)
