| Project/Area Number |
26463039
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
川尻 秀一 金沢大学, 医学系, 教授 (30291371)
加藤 広禄 金沢大学, 附属病院, 講師 (30444201)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | FAK / 浸潤様式 / 口腔扁平上皮がん / FAK pY397 / 転移 / 口腔扁平上皮癌 / インテグリン / ＦＡＫ / ＦＡＫ ｐＹ３９７ |
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| Outline of Final Research Achievements |
Mode of Invasion is a factor affecting the prognosis of oral squamous cell carcinoma (OSCC). Although various canceration related protein is concerned with cancer malignant alteration, the relation with mode of invasion is less well understood yet. To investigate the revelation between mode of invasion and canceration-related-protein, various target protein in connection with canceration was searched.Six cell lines with various invasive properties were investigated to compare the targeted protein levels (Maspin uPA, uPAR, FAK) using Western blotting method. First, expression of Maspin was lower, while uPA and uPAR was higher in high invasive cell lines compared with other low invasive cell lines. Second, positive cases of FAK showed higher local recurrence rate than negative case by immunohistochemical staining. It is necessary to clarify the furthermore underlying mechanisms between various canceration related protein and mode of invasive of OSCC.
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