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Development of the new therapeutic strategy for recurrence/metastatic oral cancer -toward natural life with oral cancer-

Research Project

Project/Area Number 26463045
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionYamaguchi University

Principal Investigator

UEYAMA Yoshiya  山口大学, 医学(系)研究科(研究院), 教授 (00168668)

Co-Investigator(Kenkyū-buntansha) 原田 耕志  山口大学, 医学(系)研究科(研究院), 助教 (60253217)
Research Collaborator FERDOUS Tarannum  山口大学, 大学院医学系研究科, 学術研究員 (70647932)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords癌幹細胞 / リプログラミング / iPS / エピソーマルベクター / IPA / スルファサラジン / 人工癌幹細胞 / 口腔癌 / CD44v / Sulfasalazine / マイクロアレイ / リプログラミングファクター / リプログラム因子 / 肝癌細胞 / 乳癌細胞 / 子宮頸癌細胞
Outline of Final Research Achievements

We made a comparison between the artificial cancer stem cells obtained by the induction of cellular reprogramming and the parental cells by microarray analysis. The expression of the factors related to the malfunction of mitochondria and the morphological or metabolic aberration of cell was increased in the artificial cancer stem cells. However, we could not find the new important factors associated to the artificial cancer stem cells. Also, we found sulfasalazine, medicine for ulcerous colitis or articular rheumatism was effective for the artificial cancer stem cells though they exhibited increased resistance to chemotherapeutic agents, molecular targeting agents and radiation. Our findings suggested that the new therapeutic strategy with sulfasalazine may be effective for recurrence/metastatic oral cancers through the regulation of oral cancer stem cells.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (8 results)

All 2016 2015 2014

All Journal Article (4 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Induction of artificial cancer stem cells from tongue cancer cells by defined reprogramming factors.2016

    • Author(s)
      Harada K, Ferdous T, Cui D, Kuramitsu Y, Matsumoto T, Ikeda E, Okano H, Ueyama Y.
    • Journal Title

      BMC Cancer

      Volume: 16 Issue: 1 Pages: 548-548

    • DOI

      10.1186/s12885-016-2416-9

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] METFORMIN IN COMBINATION WITH 5-FLUOROURACIL SUPPRESSES TUMOR GROWTH BY INHIBITING WARBURG EFFECT IN HUMAN ORAL SQUAMOUS CELL CARCINOMA2016

    • Author(s)
      Koji Harada, Tarannum Ferdous, Toyoko Harada, Yoshiya Ueyama
    • Journal Title

      International Journal of Oncology

      Volume: in press

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] High Expression of Stathmin1 is a Strong Prognostic Marker in Oral Squamous Cell Carcinoma Patients Treated by Docetaxel-containing Regimens.2015

    • Author(s)
      Koji Harada, Tarannum Ferdous, Toyoko Harada, Yoshiya Ueyama
    • Journal Title

      Clin Exp Med

      Volume: - Issue: 1 Pages: 1-6

    • DOI

      10.1007/s10238-015-0403-0

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Osteogenic cell fractions isolated from mouse tongue muscle2015

    • Author(s)
      Harada K, Harada T, Ferdous T, Takenawa T. and Ueyama Y.
    • Journal Title

      Mol. Med. Rep.

      Volume: - Issue: 1 Pages: 31-36

    • DOI

      10.3892/mmr.2015.3350

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Induction of artificial cancer stem cells from oral cancer cells by defined reprogramming factors.2016

    • Author(s)
      Yoshiya Ueyama, Koji Harada, Tarannum Ferdous
    • Organizer
      Oral, Mouth and Throat Cancer
    • Place of Presentation
      Sheraton Portland Airport Hotel, Portland, (USA)
    • Year and Date
      2016-08-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 口腔扁平上皮癌に対するMetforminと5-FUの併用療法による抗腫瘍効果の検討2016

    • Author(s)
      原田 耕志、上山 吉哉
    • Organizer
      日本頭頸部癌学会
    • Place of Presentation
      さいたま市 (ソニックシテイ)
    • Year and Date
      2016-06-09
    • Related Report
      2015 Research-status Report
  • [Presentation] リプログラミング因子導入による癌細胞の脱分化2014

    • Author(s)
      原田耕志、Ferdous T, 上山吉哉
    • Organizer
      日本口腔科学会 中国四国地方会
    • Place of Presentation
      徳島大学歯学部大講義室(徳島)
    • Year and Date
      2014-10-25
    • Related Report
      2014 Research-status Report
  • [Presentation] Establishment of Induced Cancer Stem Cells by Transfection of a Tongue Cancer Cell Line with Yamanaka‘s Factor.2014

    • Author(s)
      Harada K, Ferdous T, Harada T, Ueyama Y.
    • Organizer
      EACMFS 2014
    • Place of Presentation
      プラハ チェコ
    • Year and Date
      2014-09-23 – 2014-09-26
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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