Distinction and analysis of the distant metastasis marker in oral squamous cell carcinoma.
| Project/Area Number |
26463049
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kumamoto University |
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Principal Investigator |
TANAKA TAKUYA 熊本大学, 医学部附属病院, 診療助手 (30631767)
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| Co-Investigator(Kenkyū-buntansha) |
尾木 秀直 熊本大学, 大学院生命科学研究部(医), 助教 (10315426)
篠原 正徳 熊本大学, 医学部附属病院, 非常勤診療医師 (90117127)
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| Co-Investigator(Renkei-kenkyūsha) |
MASANORI Shinohara 熊本大学, 医学部附属病院, 非常勤診療医師 (90117127)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 転移 / Angptl4 / ANGPT4 / 口腔癌 / 遠隔転移 / NF-ｋB / 肺転移 |
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| Outline of Final Research Achievements |
Background: Angptl4 is a critical mediator and promotes trans-endothelial migration of cancer cells．We found a marked increase of Angptl4 mRNA in tongue cancer cells that metastasized into the lung (Tanaka et al, Int. J. Oncol. 2016). Thus, we investigated a relationship between tongue cancer cell Angptl4 expression and clinicopathological parameters of the patients. Methods: Immunohistochemical staining for Angptl4 was performed for tongue cancer tissues from patients who had radical surgery but not pre-operative therapies. Twenty patients with metastasis and 20 patients without metastasis were enrolled. Results: By Kaplan-Meier method, Angptl4-positive patients showed significantly shorter overall survival and recurrence-free survival than Angptl4-negative patients. Conclusion: Angptl4 is likely associated with tongue cancer progression and its expression of the cancer cells may be predictive of poor prognosis of the patients. Thus, Angptl4 is a possible therapeutic target.
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] Enhancement of active MMP release and invasive activity of lymph node metastatic tongue cancer cells by elevated signaling via the TNF-α-TNFR1-NF-κB pathway and a possible involvement of angiopoietin-like 4 in lung metastasis.2016
Author(s)
Tanaka, T., Imamura, T., Yoneda, M., Irie, A., Ogi, H., Nagata, M., Yoshida, R., Fukuma, D., Kawahara, K., Shinohara, M, & Nakayama, H.
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Journal Title
Int. J. Oncol.
Volume: 49
Issue: 4
Pages: 1377-1384
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The tumour stromal features are associated with resistance to 5-FU-based chemoradiotherapy and a poor prognosis in patients with oral squamous cell carcinoma.2015
Author(s)
Matsuoka Y, Yoshida R, Nakayama H, Nagata M, Hirosue A, Tanaka T, Kawahara K, Nakagawa Y, Sakata J, Arita H, Hiraki A, Shinohara M.
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Journal Title
APMIS
Volume: 123
Pages: 205-214
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] A case of adenomatoid odontogenic tumor-like tumor, unusual benign odontogenic tumor in the maxilla. J Maxillofac Surg Med Pathol. 27(2): 299-302. (2015)2015
Author(s)
Kenta Kawahara, Hideki Nakayama, Daiki Fukuma, Masashi Nagata, Ryoji Yoshida, Takuya Tanaka, Yoshihiro Nakagawa, Akiyuki Hirosue, Akimitsu Hiraki, Yasunori Takeda, Masanori Shinohara.
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Journal Title
J Maxillofac Surg Med Pathol
Volume: 27
Pages: 299-302
Related Report
Peer Reviewed / Acknowledgement Compliant
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