Molecular pathology of phenotypic chenges in lesions of jow bones

• Project/Area Number: 26463054
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Matsumoto Dental University
• Principal Investigator: Hasegawa Hiromasa 松本歯科大学, 歯学部, 教授 (60164828)
• Co-Investigator(Kenkyū-buntansha): 中野 敬介 岡山大学, 医歯薬学総合研究科, 准教授 (10325095) ; 落合 隆永 松本歯科大学, 歯学部, 講師 (20410417)
• Co-Investigator(Renkei-kenkyūsha): TSUJIGIWA Hidetsugu 岡山理科大学, 理学部, 教授 (70335628)
• Research Collaborator: SHIMADA Katsumitsu
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 分子病理学 / 臨床腫瘍学 / 形質発現 / 顎骨部病変

Outline of Final Research Achievements

Odontogenic lesions sometimes appear many kinds of abnormal morphologic chenges. Therefore, we examine the localization of neuroendocrine cell markers and cornified cell envelop (CE) related proteins in odontogenic lesions. CD56 and synaptophysin co-expressed in some parts of columnar cells in ameloblastomas. Furthermore, the mRNA expressed both CD56 and synaptophysin. CE related proteins showed various expression depending on the lesions. Our result suggest that CD56-positive cells partially differentiated into synaptophysin-positive cells in ameloblastomas. CE related proteins play important roles in odontogenic lesions. The examination of neuroendocrine cell markers and CE related protein expression could clarify the differentiation of some odontogenic lesions.

Research Products

• [Presentation] Cornified cell envelope related proteins in odontogenic tumors (2016)
  • Author(s): Takanaga Ochiai, Katsumitsu Shimada and Hiromasa Hasegawa
  • Organizer: 13th Biennal congress of the European association of oral medicine
  • Place of Presentation: Turin (Itary)
  • Year and Date: 2016-09-15
  • Int'l Joint Research
• [Presentation] Small proline-rich proteins in keratocystic odontogenic tumor (2016)
  • Author(s): Katsumitsu Shimada, Takanaga Ochiai and Hiromasa Hasegawa
  • Organizer: 13th Biennal congress of the European association of oral medicine
  • Place of Presentation: Turin (Itary)
  • Year and Date: 2016-09-15
  • Int'l Joint Research
• [Presentation] 角化嚢胞性歯原性腫瘍の角化機序 (2016)
  • Author(s): 落合隆永，中野敬介，長谷川博雅
  • Organizer: 第58回歯科基礎医学会
  • Place of Presentation: 札幌コンベンションセンター（北海道）
  • Year and Date: 2016-08-26
• [Presentation] Cornified cell envelope related proteins in ghost cells (2016)
  • Author(s): Takanaga Ochiai, Katsumitsu Shimada and Hiromasa Hasegawa
  • Organizer: 第27回日本臨床口腔病理学会
  • Place of Presentation: 広島大学 広仁会館（広島県）
  • Year and Date: 2016-08-12
• [Presentation] 下顎骨病変 (2016)
  • Author(s): 落合隆永，嶋田勝光，保坂典子，長谷川博雅
  • Organizer: 第56回日本骨軟部腫瘍研究会
  • Place of Presentation: 樺細工伝承館（秋田県）
  • Year and Date: 2016-06-25
• [Presentation] Immunohistochemical analysis of cornified cell envelope related proteins in keratocystic odontogenic tumor. (2015)
  • Author(s): 落合隆永、中野敬介、長谷川博雅
  • Organizer: 第57回歯科基礎医学会学術大会
  • Place of Presentation: 朱鷺メッセ（新潟県新潟市）
  • Year and Date: 2015-09-13
• [Presentation] 歯原性の幽霊細胞における角化関連因子の免疫組織学的検討． (2015)
  • Author(s): 落合隆永、嶋田勝光、中野敬介、長谷川博雅
  • Organizer: 第26回日本臨床口腔病理学会総会・学術大会
  • Place of Presentation: 北海道大学学術交流会館（北海道札幌市）
  • Year and Date: 2015-07-31
• [Presentation] CD56の新たな単嚢胞性エナメル上皮腫マーカーとしての可能性 (2014)
  • Author(s): 落合隆永、嶋田勝光、中野敬介、長谷川博雅
  • Organizer: 第60回日本病理学会秋季特別総会
  • Place of Presentation: 国立劇場おきなわ（沖縄県浦添市）
  • Year and Date: 2014-11-20
• [Presentation] Expression of neuroendocrine cell markers in ameloblastomas (2014)
  • Author(s): Takanaga Ochiai, Keisuke Nakano, Hiromasa Hasegawa
  • Organizer: 17th International Congress on Oral Pathology and Medicine
  • Place of Presentation: Harbiye Military Museum and Cultural Centre (Istanbul, Turkey)
  • Year and Date: 2014-05-29