| Project/Area Number |
26463066
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SOGAWA Chiharu 岡山大学, 大学院医歯薬学総合研究科, 講師 (10253022)
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| Research Collaborator |
IKEDA Akihiro University of Wisconsin-Madison, Department of Medical Genetics, Professor
TAJIRI Ayako 岡山大学, 大学院医歯薬学総合研究科, 大学院生
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | Transmembrane135 / 中枢細胞 / シナプス小胞 / TMEM135 / 中枢神経 / 老化 / 神経変性 / シナプス / 神経 |
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| Outline of Final Research Achievements |
The gene decoding projects in the world identified all genome sequence of human, mouse et al., and they indicated that there were still a lot of unknown genes and proteins. In this study, I evaluated the function of Tmem135(transmenbrane135) that was one of unknown gene, in synaptic vesicles. In results, TMEM135 was expressed in hippocampus neurons, and it was suggested the possibility that TMEM135 was contributed to the glutamate uptake of the synaptic vesicles.
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