Elucidation of epigenetic regulation in regeneration of tongue muscle
Project/Area Number |
26463103
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthodontics/Pediatric dentistry
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Research Institution | Tsurumi University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
安藤 準 鶴見大学, 歯学部, 講師 (00282765)
大久保 力廣 鶴見大学, 歯学部, 教授 (10223760)
成山 明具美 鶴見大学, 歯学部, 助教 (90440304)
|
Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | エピジェネティクス / 舌 / 発生 / 舌筋 / 再生 / iPS |
Outline of Final Research Achievements |
This study aims at establishment of condition to induce tongue muscle from non-muscle cells especially thorough epigenetic approaches. We tried to induce tongue muscle cells from iPS cells. However, we could not find efficient condition for the induction of tongue muscle. We then investigated epigenetic regulation of embryonic tongue formation in vivo. We found that expression of a histone H3K9 methyltransferase gene, G9a, is required for proper tongue formation.
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Report
(5 results)
Research Products
(23 results)
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[Journal Article] Clinical application of removable partial dentures using thermoplastic resin—Part I: Definition and indication of non-metal clasp dentures2014
Author(s)
Fueki K, Ohkubo C, Yatabe M, Arakawa I, Arita M, Ino S, Kanamori T, Kawai Y, Kawara M, Komiyama O, Suzuki T, Nagata K, Hosoki M, Masumi S, Yamauchi M, Aita H, Ono T, Kondo H, Tamaki K, Matsuka Y, Tsukasaki H, Fujisawa M, Baba K, Koyano K,Yatani H.
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Journal Title
Journal of Prosthodontic Research
Volume: 58
Issue: 1
Pages: 3-10
DOI
NAID
ISSN
1883-1958, 1883-9207
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical application of removable partial dentures using thermoplastic resin. Part II: Material properties and clinical features of non-metal clasp dentures2014
Author(s)
Fueki K, Ohkubo C, Yatabe M, Arakawa I, Arita M, Ino S, Kanamori T, Kawai Y, Kawara M, Komiyama O, Suzuki T, Nagata K, Hosoki M, Masumi S, Yamauchi M, Aita H, Ono T, Kondo H, Tamaki K, Matsuka Y, Tsukasaki H, Fujisawa M, Baba K, Koyano K,Yatani H.
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Journal Title
Journal of Prosthodontic Research
Volume: 58
Issue: 2
Pages: 71-84
DOI
NAID
ISSN
1883-1958, 1883-9207
Related Report
Peer Reviewed / Open Access
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