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Cooperation of Histone Decetylase and Glucose Transporters during tooth development

Research Project

Project/Area Number 26463117
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthodontics/Pediatric dentistry
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

Masato Saitoh  北海道医療大学, 歯学部, 教授 (50337036)

Co-Investigator(Kenkyū-buntansha) 谷村 明彦  北海道医療大学, 歯学部, 教授 (70217149)
安彦 善裕  北海道医療大学, 歯学部, 教授 (90260819)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsエピジェネティックス / 歯胚発生 / カルシウムシグナリング / カルシウム応答 / 歯牙発生 / 石灰化遺伝子 / エピジェネティクス
Outline of Final Research Achievements

Glucose, an essential source of energy for determination of size and form during tooth development, is transported across the cell membrane by glucose transporters (GLUTs). Modulation of Ca is a signaling system involved in the regulation of a wide range of biological processes including contraction, secretion, gene expression, proliferation, and differentiation . In the present study, we observe to plays a role with GLUTs and Ca signaling during tooth development .

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (14 results)

All 2016 2015 2014

All Journal Article (5 results) (of which Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (9 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Murata K, Takahashi A, Morita T, Nezu A, Fukumoto S, Saitoh M, Tanimura A.2016

    • Author(s)
      Effect of 1,25-dihydroxyvitamin D3 on spontaneous calcium responses in rat dental epithelial SF2 cells revealed by long-term imaging.
    • Journal Title

      Biomed Res.

      Volume: 37(6) Pages: 329-334

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of epithelial cells derived from periodontal ligament on osteoblast-like cells in a Transwell membrane coculture system.2015

    • Author(s)
      Noro D, Kurashige Y, Shudo K, Takahashi A, Abiko Y, Saitoh M.
    • Journal Title

      Arch Oral Biol.

      Volume: 60(7) Pages: 1007-1012

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differentiation of mouse iPS cells into ameloblast-like cells in cultures using medium conditioned by epithelial cell rests of Malassez and gelatin-coated dishes.2015

    • Author(s)
      Yoshida K, Sato J, Takai R, Uehara O, Kurashige Y, Nishimura M, Chiba I, Saitoh M, Abiko Y.
    • Journal Title

      Med Mol Morphol.

      Volume: 48(3) Pages: 138-145

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fluoride retention in saliva following toothbrushing using different types of fluoridated dentifrices containing 1500 ppm F of NaF and MFP.2015

    • Author(s)
      Mina Hirose, Yukie Murata, Atsushi Fukuda, Yusuke Fujita, Maiko Otomo, Shoko Yahata, Masato Saitoh.
    • Journal Title

      Pediatri Dent J.

      Volume: 25(2) Pages: 39-54

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 歯胚の発育過程におけるエピジェネティクス関連酵素HDACsと糖代謝関連因子の関与について2014

    • Author(s)
      佐々木 由希子, 倉重 圭史, 齊藤 正人, 安彦 善裕, 坂倉 康則
    • Journal Title

      小児歯科学雑誌

      Volume: 52 Pages: 425-432

    • NAID

      130005084434

    • Related Report
      2014 Research-status Report
  • [Presentation] Role . Role of the Ca 2+ responses in the rat dental epithelial cells. responses in the rat dental epithelial cells.2016

    • Author(s)
      村田 佳織,高橋 佳織,高橋 亜友美,石川 亜友美,石川 亮子,倉重 亮子,倉重 圭史,村井 圭史,村井 雄司,谷村 雄司,谷村 雄司,谷村 明彦,齊藤 明彦,齊藤 正人 .
    • Organizer
      第 10 回アジ小児歯科学会 大会/第 54 回日本小児歯科学会大会
    • Place of Presentation
      東京ドームホテル
    • Year and Date
      2016-05-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒト歯肉線維芽細胞内カルシウムイオン調節機構におけるフェニ トインの関与2015

    • Author(s)
      高橋亜友美,梶 美奈子,尾立達治,倉重圭史,村井雄司,村田佳織,高藤美帆子,川村玲 衣,広瀬弥奈,齊藤正人.
    • Organizer
      第32回日本障害者歯科学会総会および学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-11-06
    • Related Report
      2015 Research-status Report
  • [Presentation] ビタミン D による分化 誘導時の歯原性上皮細胞における Ca2+応答の発生機序2015

    • Author(s)
      村田佳織,倉重圭史,森田貴雄,高橋亜友美,齊藤正人,谷村明彦.
    • Organizer
      第57回歯科基礎医学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
  • [Presentation] Production and Purification of Recombinant Amelogenin in mammalian cells.2015

    • Author(s)
      高橋亜友美,森田貴雄,倉重圭史,村田佳織,谷村明彦,齊藤正人.
    • Organizer
      第57回歯科基礎医学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
  • [Presentation] ヒトリコンビナントアメロジェニ ンの精製法の確立2015

    • Author(s)
      高橋亜友美,倉重圭史,村田佳織,谷村明彦,齊藤正人.
    • Organizer
      第53回日本小児歯科学会大会
    • Place of Presentation
      広島
    • Year and Date
      2015-05-21
    • Related Report
      2015 Research-status Report
  • [Presentation] VITAMIN D-INDUCED CALCIUM SIGNALS AND DIFFERENTIATION IN DENTAL EPITHELIAL CELLS.2014

    • Author(s)
      Murata K, Tanimura A, Fukumoto S, Kurashige Y, Abiko Y, Saitoh M.
    • Organizer
      IADR/PER Congress
    • Place of Presentation
      Dubrovnik Croatia
    • Year and Date
      2014-10-10 – 2014-10-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 競合的蛍光リガンド結合アッセイ法を活用した新規IP3分子センサーの開発2014

    • Author(s)
      谷村明彦,村田佳織,齊藤正人,森田貴雄,根津顕弘
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      博多
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] ビタミンDによる分化誘導でおこる歯原性上皮細胞のCa2+応答2014

    • Author(s)
      村田佳織,森田貴雄,倉重圭史,高橋亜友美,齊藤正人,谷村明彦.
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      博多
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] ビタミンDによるラット歯原性上皮細胞の分化とCa2+応答の関係2014

    • Author(s)
      村田佳織,倉重圭史,林良宣,高橋亜友美,谷村明彦,齊藤正人.
    • Organizer
      第52回日本小児歯科学会
    • Place of Presentation
      品川
    • Year and Date
      2014-05-16 – 2014-05-17
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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