Epigenetics in the postnatal development of masticatory muscles
| Project/Area Number |
26463127
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
安藤 準 鶴見大学, 歯学部, 講師 (00282765)
福井 只美 鶴見大学, 歯学部, 非常勤講師 (10267544)
朝田 芳信 鶴見大学, 歯学部, 教授 (20184145)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 咀嚼筋 / 非咬合モデルマウス / 生後発達 / エピジェネティクス |
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| Outline of Final Research Achievements |
The regulatory pathway of miR-1 via HDAC4 and MEF2 plays a more prominent role during postnatal development in the masseter muscle than in the gastrocnemius muscle, whereas that of miR-133a via SRF plays a more prominent role in the gastrocnemius muscle than in the masseter muscle.
MiR-1 promotes the differentiation of skeletal muscle directly through the post-transcriptional inhibition of HDAC4 expression and that miR-133a promotes the proliferation of skeletal muscle directly through the post-transcriptional inhibition of SRF expression.
MiR-1 promotes the differentiation of skeletal muscle directly through the post-transcriptional inhibition of HDAC4 expression and that miR-133a promotes the proliferation of skeletal muscle directly through the post-transcriptional inhibition of SRF expression.
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Report
(4 results)
Research Products
(13 results)
