Biological responses due to bacteremia following scaling and application effects of optical energy
Project/Area Number |
26463132
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Periodontology
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Research Institution | Niigata University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
小松 康高 新潟大学, 医歯学総合病院, 助教 (40422597)
清水 太郎 新潟大学, 医歯学総合病院, 医員 (60609121)
久保田 健彦 新潟大学, 医歯学総合病院, 講師 (50303136)
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 生体応答 / 炎症性サイトカイン / スケーリング / ミノサイクリン / 抗菌的光線力学療法 / 歯周治療 |
Outline of Final Research Achievements |
Intense non-surgical periodontal therapy including scaling and root planing (SRP) acts as a potent inflammatory stimulus immediately after treatment, and induces an acute inflammatory response. In the study, we demonstrated that full-mouth SRP produced a moderate systemic acute-phase response 1 day post-treatment, while pre-treatment of azithromycin could inhibit the those response. In addition, we found that local administration of minocycline ointment may slightly help to improve clinical, microbiological, and crevicular cytokine levels in periodontal pockets not yet treated with subgingival scaling.
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Report
(5 results)
Research Products
(43 results)
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[Journal Article] Increased systemic levels of inflammatory mediators following one-stage full-mouth scaling and root planing2018
Author(s)
Morozumi T, Yashima A, Gomi K, Ujiie Y, Izumi Y, Akizuki T, Mizutani K, Takamatsu H, Minabe M, Miyauchi S, Yoshino T, Tanaka M, Tanaka Y, Hokari T, Yoshie H
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Journal Title
Journal of Periodontal Research
Volume: 印刷中
Issue: 4
Pages: 536-544
DOI
Related Report
Peer Reviewed
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[Journal Article] Salivary pathogen and serum antibody to assess the progression of chronic periodontitis: a 24-mo prospective multicenter cohort study2016
Author(s)
Morozumi T, Nakagawa T, Nomura Y, Sugaya T, Kawanami M, Suzuki F, Takahashi K, Abe Y, Sato S, Makino-Oi A, Saito A, Takano S, Minabe M, Nakayama Y, Ogata Y, Kobayashi H, Izumi Y, Sugano N, …., Yoshimura A, Hara Y, ….
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Journal Title
Journal of Periodontal Research
Volume: 印刷中
Issue: 6
Pages: 768-778
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Clinical usefulness of a novel immunochromatographic detection device for Porphyromonas gingivalis in evaluating the effects of scaling and root planing and local antimicrobial therapy2016
Author(s)
Nakayama Y, Ogata Y, Hiromatsu Y, Imamura K, Suzuki E, Saito A, Shirakawa S, Nagano T, Gomi K, Morozumi T, Watanabe K, Akiishi K, Yoshie H
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Journal Title
Journal of Periodontology
Volume: 7
Issue: 10
Pages: 1238-1247
DOI
Related Report
Peer Reviewed
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[Journal Article] Evaluation of a novel immunochromatographic device for rapid and accurate clinical detection of Porphyromonas gingivalis in subgingival plaque2015
Author(s)
Imamura K, Takayama S, Saito A, Inoue E, Nakayama Y, Ogata Y, Shirakawa S, Nagano T, Gomi K, Morozumi T, Akiishi K, Watanabe K, Yoshie H
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Journal Title
Journal of Microbiological Methods
Volume: 117
Pages: 4-10
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 歯肉縁下細菌と血清抗体価による慢性歯周炎進行の予知判定:24ヵ月多施設前向きコホート研究2017
Author(s)
両角俊哉,中川種昭,野口和行,原 宜興,西村英紀,梅田 誠,野口俊英,吉成伸夫,沼部幸博, 伊藤公一,和泉雄一,小方頼昌,三邉正人,齋藤 淳,佐藤 聡,高橋慶壮,川浪雅光,花田信弘, 高柴正悟,吉江弘正
Organizer
日本歯科保存学会2017年度春季学術大会
Related Report
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[Presentation] Systemic and local biological response following one-stage full-mouth scaling and root planning2017
Author(s)
Morozumi1 T, Yashima A, Gomi K, Ujiie Y, Izumi Y, Akizuki T, Mizutani K, Takamatsu H, Minabe M, Miyauchi S, Yoshino T, Tanaka M, Tanaka Y, Hokari T, Yoshie H
Organizer
12th Asian Pacific Society of Periodontology
Related Report
Int'l Joint Research
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[Presentation] Expression of neprilysin in periodontitis-affected gingival tissues2016
Author(s)
Nezu A, Kubota T, Maruyama S, Nagata M, Horimizu M, Nouno K, Hokari T, Morozumi T, Saku T, Yoshie H
Organizer
The 102nd Annual Meeting of the American Academy of Periodontology in collaboration with the Japanese Society of Periodontology and Japanese Academy of Clinical Periodontology
Place of Presentation
San Diego Convention Center (San Diego, CA, U.S.A.)
Year and Date
2016-09-10
Related Report
Int'l Joint Research
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[Presentation] Biological effects of a-PDT and LDDS in chronic periodontitis2016
Author(s)
Hokari T, Morozumi T, Komatsu Y, Yoshino T, Shimizu T, Tanaka M, Tanaka Y, Kubota T, Yoshie H
Organizer
The 102nd Annual Meeting of the American Academy of Periodontology in collaboration with the Japanese Society of Periodontology and Japanese Academy of Clinical Periodontology
Place of Presentation
San Diego Convention Center (San Diego, CA, U.S.A.)
Year and Date
2016-09-10
Related Report
Int'l Joint Research
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[Presentation] Full-mouth SRP後の生体応答と臨床効果2015
Author(s)
両角俊哉, 保苅崇大, 八島章博, 氏家優子, 五味一博, 水谷幸嗣, 高松秀行, 和泉雄一, 秋月達也, 宮内里美, 三邉正人, 田中真喜, 田中良枝, 吉野敏明, 吉江弘正
Organizer
第58回秋季日本歯周病学会学術大会
Place of Presentation
アクトシティ浜松(静岡県浜松市)
Year and Date
2015-09-12
Related Report
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