| Project/Area Number |
26463132
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小松 康高 新潟大学, 医歯学総合病院, 助教 (40422597)
清水 太郎 新潟大学, 医歯学総合病院, 医員 (60609121)
久保田 健彦 新潟大学, 医歯学総合病院, 講師 (50303136)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 生体応答 / 炎症性サイトカイン / スケーリング / ミノサイクリン / 抗菌的光線力学療法 / 歯周治療 |
|---|
| Outline of Final Research Achievements |
Intense non-surgical periodontal therapy including scaling and root planing (SRP) acts as a potent inflammatory stimulus immediately after treatment, and induces an acute inflammatory response. In the study, we demonstrated that full-mouth SRP produced a moderate systemic acute-phase response 1 day post-treatment, while pre-treatment of azithromycin could inhibit the those response. In addition, we found that local administration of minocycline ointment may slightly help to improve clinical, microbiological, and crevicular cytokine levels in periodontal pockets not yet treated with subgingival scaling.
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