The effect of cell-derived microparticles on the homeostasis of periodontal tissue
| Project/Area Number |
26463133
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Periodontology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山下 元三 大阪大学, 歯学研究科, 助教 (90524984)
竹立 匡秀 大阪大学, 歯学研究科, 助教 (60452447)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | マイクロパーティクル / 細胞由来マイクロパーティクル / 細胞由来マイクロパーティクルマイクロパーティクル |
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| Outline of Final Research Achievements |
We have examined the effect of cell-derived microparticles (MP) on homeostasis of gingival cells. Endothelial cell-derived microparticles (EMP) released from the cells with LPS or inflammatory cytokine expressed annexin, ICAM-1 and HLA-DR higher than EMP from the non-stimulated cells. IL-8 expression in human gingival fibroblasts in the presence of EMP released from the cells with LPS or inflammatory cytokine was significantly elevated compared with EMP from non-stimulated cells. These results suggested that MP released from cells stimulated with inflammatory stimulation could be inflammatory factor.
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Report
(4 results)
Research Products
(10 results)
