| Project/Area Number |
26463191
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Ohu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TAMAI Riyoko 奥羽大学, 歯学部, 准教授 (90367566)
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| Research Collaborator |
KOBAYASHI Michiyo
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | Candida albicans / 口腔カンジダ症 / IL-1alpha / 抗体医薬 / 炎症性サイトカイン / 全身性カンジダ症 / IL-1α / 抗菌ペプチド |
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| Outline of Final Research Achievements |
In this study, in order to elucidate the mechanism by which immunosuppression by antibody medicine use of elderly rheumatism causes candidiasis and establish a new preventive method, after administering the antibody to the inflammatory cytokine to the mouse, Candida albicans is administered intraorally And in vivo experiments were carried out. As a result, the number of bacteria of C. albicans in feces was increased in the mouse to which the anti-IL-1α antibody had been administered, but it was not changed by the anti-IL-6 antibody. IL-1α production in the tongue tissues of anti-IL-1α antibody-treated mice was almost suppressed, but there was no increase or decrease in other cytokine production. These results suggest that IL-1α is extremely important in preventing the establishment of C. albicans in the body.
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