Morphological study of angiogenesis and type III collagen synthesis in diabetic wound healing
| Project/Area Number |
26463213
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Fundamental nursing
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| Research Institution | Saitama Prefectural University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
金村 尚彦 埼玉県立大学, 保健医療福祉学部, 教授 (20379895)
武田 美津代 埼玉県立大学, 保健医療福祉学部, 准教授 (90279852)
成瀬 秀夫 東京有明医療大学, 保健医療学部, 教授 (40563416)
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| Research Collaborator |
GOMI Toshiaki
KIMURA Akihiko
TERAJIMA Miho
ITOH Sayami
IWATA Kayako
KONG Lingshuai
UTHIKURA Chie
OOTAKE Emi
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 創傷治癒 / 糖尿病 / 血管新生 / VEGF / 免疫組織化学 / 3型コラーゲン |
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| Outline of Final Research Achievements |
The wound healing in diabetes was taken for morphological analyses. For the experiments, diabetic male mice were used and immunohistological analysis for angiogenesis, blood flow and formation of type III collagen.
As a result, a delay of 2 to 3 days was observed in angiogenesis in wound healing process in diabetes than in normal cases. Blood flow was observed in new blood vessels after 1 or 2 days. Formation of type III collagen was observed consistent with the onset of blood flow. These results may suggest that the cause of delay in wound healing in diabetic mice is one of the causes of the delay in angiogenesis and the delay in starting blood flow, which makes it impossible to supply the wound with the nutrition
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Report
(4 results)
Research Products
(4 results)
