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Attempts of tailor-made nutrition by sub-analysis of human interventional study aimed at establishing preventive methods for dementia/depression

Research Project

Project/Area Number 26500008
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Integrated Nutrition Science
Research InstitutionShimane University

Principal Investigator

Hashimoto Michio  島根大学, 医学部, 特任教授 (70112133)

Co-Investigator(Kenkyū-buntansha) 片倉 賢紀  城西大学, 薬学部, 准教授 (40383179)
Co-Investigator(Renkei-kenkyūsha) KAGAWA Yasuo  女子栄養大学, 栄養学部, 教授 (30048962)
Research Collaborator KATO Setsushi  仁寿会, 加藤病院, 院長
ONO Miho  仁寿会, 加藤病院, 管理栄養士
OKUI Toshiyuki  島根大学, 医学部, 特別研究協力員
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords認知症予防 / 高齢者介入試験 / コホート疫学研究 / 魚油 / 超高水圧加圧玄米 / やる気とうつ予防 / テーラーメイド栄養 / 機能性食品の開発 / 高齢者 / 認知機能維持 / 骨密度維持 / エゴマ油 / 超高水圧加工玄米 / ヒト介入試験 / 認知機能 / 情動 / 縦断的疫学研究 / 脳トレ / ω3系脂肪酸 / 遺伝子多型
Outline of Final Research Achievements

Epidemiological survey data analysis of the Shimane COHRE Study in 2012 and 2014 suggested that motivation of female elderly people is higher than that of male elderly people, and also that an increase in intake frequency of blue fish alleviates depression and improves motivation It was done.
In a healthy elderly intervention trial, ingesting ultrahigh pressure pressurized brown rice for 12 months strengthened the bones of the elderly and improved their motivation. Their interventional trial of combination of perilla oil ingestion and brain training also improved their frontal lobe function. Furthermore, dietary docosahexaenoic acid intervention for 12 months protect against age-related cognitive decline, and also improve apathy and caregiver burden for the oldest-elderly people with cognitive impairment, such as dementia.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (63 results)

All 2017 2016 2015 2014

All Journal Article (22 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 19 results,  Open Access: 17 results,  Acknowledgement Compliant: 9 results) Presentation (40 results) (of which Int'l Joint Research: 5 results,  Invited: 17 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Effect of dietary n-3 fatty acids supplementation on fatty acid metabolism in atorvastatin-administered SHR.Cg-Leprcp/NDmcr rats, a metabolic syndrome model.2017

    • Author(s)
      Abdullah Al Mamun, Michio Hashimoto, Masanori Katakura, Yoko Tanabe, Satoru Tsuchikura, Shahdat Hossain, Osam Shido
    • Journal Title

      Biomed Pharmacother

      Volume: 85 Pages: 372-379

    • DOI

      10.1016/j.biopha.2016.11.038

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Differential effects of docoosahexaenoic and arachidonic acid on fatty acid composition and myosin heavy chain-related genes of slow- and fast-twitch skeletal muscle tissues.2016

    • Author(s)
      M. Hashimoto, T. Inoue, M. Katakura, S. Hossain, AA. Mamun, K. Matsuzaki, H. Arai, O. Shido.
    • Journal Title

      Mol Cell Biochem.

      Volume: 415 Issue: 1-2 Pages: 169-181

    • DOI

      10.1007/s11010-016-2689-y

    • NAID

      120006938645

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Beneficial effects of dietary docosahexaenoic acid intervention on cognitive function and mental health of the oldest elderly in Japanese care facilities and nursing homes.2016

    • Author(s)
      M. Hashimoto, S. Kato, Y. Tanabe, M. Katakura, AA. Mamun, M. Ohno, S. Hossain, K. Onoda, S. Yamaguchi, O. Shido.
    • Journal Title

      Geriatr Gerontol Int.

      Volume: 2016 Issue: 2 Pages: 330-337

    • DOI

      10.1111/ggi.12691

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Computational analyses of docosahexaenoic acid (DHA, C22:6, n-3) with Alzheimer’s disease-causing amyloid peptide Aβ1-42 reassures its therapeutic utility.2016

    • Author(s)
      Michio Hashimoto, Shahdat Hossain, Kentaro Matsuzaki, Abdullah Al Mamun, Hiroyuki Arai, Osamu Shido.
    • Journal Title

      Advances in Alzheimer’s Disease

      Volume: 5 Pages: 73-86

    • NAID

      120006901568

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Docosahexaenoic Acid: One Molecule Diverse Functions.2016

    • Author(s)
      Michio Hashimoto, Shahdat Hossain, Abdullah Al Mamun, Kentaro Matsuzaki, Hiroyuki Arai.
    • Journal Title

      Critical Reviews in Biotechnology

      Volume: 17 Issue: 5 Pages: 1-19

    • DOI

      10.1080/07388551.2016.1207153

    • NAID

      120006938644

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Proximate composition and fatty acid analysis of Lablab purpureus (L.) legume seed: implicates to both protein and essential fatty acid supplementation.2016

    • Author(s)
      Shahdat Hossain, Ahmed R, Bhowmick S, Mamun AA, Michio Hashimoto.
    • Journal Title

      Springer Plus

      Volume: 5(1) Issue: 1 Pages: 1899-1899

    • DOI

      10.1186/s40064-016-3587-1

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 食、特にn-3系脂肪酸摂取による認知症予防と介護者負担軽減効果2016

    • Author(s)
      橋本道男
    • Journal Title

      食品と開発

      Volume: 51(3) Pages: 9-12

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 食事-認知症予防の観点から-2016

    • Author(s)
      橋本道男
    • Journal Title

      臨床精神医学

      Volume: 45(5) Pages: 605-615

    • Related Report
      2016 Annual Research Report
    • Open Access
  • [Journal Article] Effects of Drying Methods and Pre-treatment Conditions on the Functional Component Contents and Antioxidant Activities in Egoma (<i>Perilla frutescens </i>(L.) Bitt. var. <i>frutescens</i>) Leaves2016

    • Author(s)
      小川哲郎、近重克幸、荒木英稀、北川 優、勝部拓矢、太田ゆかり、山崎幸一、橋本道男、東 敬子
    • Journal Title

      Nippon Shokuhin Kagaku Kogaku Kaishi

      Volume: 63 Issue: 5 Pages: 217-224

    • DOI

      10.3136/nskkk.63.217

    • NAID

      130005159639

    • ISSN
      1341-027X, 1881-6681
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] オメガ3系脂肪酸の健康増進効果と介護食品への期待2016

    • Author(s)
      加藤節司、大野美穂、橋本道男
    • Journal Title

      BIO INDUSTRY

      Volume: 33(8) Pages: 60-69

    • Related Report
      2016 Annual Research Report
  • [Journal Article] The binding of Aβ1-42 to lipid rafts of RBC is enhanced by dietary docosahexaenoic acid in rats: Implicates to Alzheimer's disease.2015

    • Author(s)
      M. Hashimoto, S. Hossain, M. Katakura, A. Mamun, O. Shido.
    • Journal Title

      Biochim Biophys Acta.

      Volume: 1848 Issue: 6 Pages: 1402-1409

    • DOI

      10.1016/j.bbamem.2015.03.008

    • NAID

      120006938649

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Medicinal value of asiaticoside for Alzheimer’s disease as assessed using single-molecule-detection fluorescence correlation spectroscopy, laser-scanning microscopy, transmission electron microscopy, and in silico docking.2015

    • Author(s)
      S. Hossain, M. Hashimoto, M. Katakura, A. Mamun, O. Shido.
    • Journal Title

      BMC Complementary and Alternative Medicine.

      Volume: 15 Issue: 1 Pages: 118-118

    • DOI

      10.1186/s12906-015-0620-9

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chronic arachidonic acid administration decreases docosahexaenoic acid- and eicosapentaenoic acid-derived metabolites in kidneys of aged rats.2015

    • Author(s)
      Katakura Masanori, Hashimoto Michio, Inoue Takayuki, Mamun Al Abdullah, Tanabe Yoko, Arita Makoto, Shido Osamu.
    • Journal Title

      PLOS One.

      Volume: 10

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The interaction of Apolipoprotein A5 gene promoter region T-1131C polymorphism (rs12286037) and lifestyle modification on plasma triglyceride levels in Japanese.2015

    • Author(s)
      Yamasaki Masayuki, Mutombo PBW Bitadi,Iwamoto Mamiko, Nogi Akiko, Shiwaku Kuninori
    • Journal Title

      Nutrition research and practice

      Volume: 9 Issue: 4 Pages: 379-384

    • DOI

      10.4162/nrp.2015.9.4.379

    • NAID

      120006334824

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Alterations in the Levels of Amyloid-β, Phospholipid Hydroperoxide, and Plasmalogen in the Blood of Patients with Alzheimer's Disease: Possible Interactions between Amyloid-β and These Lipids.2015

    • Author(s)
      Yamashita S, Kiko T, Fujiwara H, Hashimoto M, Nakagawa K, Kinoshita M, Furukawa K, Arai H, Miyazawa T
    • Journal Title

      J Alzheimers Dis.

      Volume: 50 Issue: 2 Pages: 527-537

    • DOI

      10.3233/jad-150640

    • NAID

      120006938646

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuroprotective effect of thymoquinone against glutamate-induced toxicity in SH-SY5Y cells.2015

    • Author(s)
      Abdullah Al Mamun, Michio Hashimoto, Masanori Katakura, Shahdat Hossain, Osamu Shido.
    • Journal Title

      Current Topics in Nutraceutical Research

      Volume: 13

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] n-3 fatty acids effectively improve the reference memory-related learning ability associated with increased brain docosahexaenoic acid-derived docosanoids in aged rats.2015

    • Author(s)
      Hashimoto M, Katakura M, Tanabe Y, Al Mamun A, Inoue T, Hossain S, Arita M, Shido O.
    • Journal Title

      Biochim. Biophys. Acta

      Volume: 1851 Issue: 2 Pages: 203-209

    • DOI

      10.1016/j.bbalip.2014.10.009

    • NAID

      120006938648

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 生活習慣と認知症:食事と運動による認知症予防2015

    • Author(s)
      橋本道男
    • Journal Title

      Dementia Japan

      Volume: 29 Pages: 9-25

    • NAID

      120006940037

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effects of Krill-derived phospholipid-enriched n-3 fatty acids on Ca(2+) regulation system in cerebral arteries from ovariectomized rats2014

    • Author(s)
      Yasushi Sakai, Michio Hashimoto, Budbazar Enkhjargal, Hisashi Mitsuishi, Hiromi Nobe, Ichiro Horie, Takahiro Iwamoto, Kenichi Yanagimoto
    • Journal Title

      Life Sciences

      Volume: 100(1) Issue: 1 Pages: 18-24

    • DOI

      10.1016/j.lfs.2014.01.070

    • NAID

      120006938651

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Omega-3 fatty acids protect renal functions by increasing docosahexaenoic acid-derived metabolite levels in SHR.Cg-Leprcp/NDmcr rats, a metabolic syndrome model.2014

    • Author(s)
      Katakura M, Hashimoto M, Inoue T, Al Mamun A, Tanabe Y, Iwamoto R, Arita M, Tsuchikura S, Shido O.
    • Journal Title

      Molecules

      Volume: 15 Issue: 3 Pages: 3247-3263

    • DOI

      10.3390/molecules19033247

    • NAID

      120006901571

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of chronic administration of arachidonic acid on lipid profiles and morphology in the skeletal muscles of aged rats2014

    • Author(s)
      Inoue T, Hashimoto M, Katakura M, Tanabe Y, Al Mamun A, Matsuzaki K, Otani H, Shido O
    • Journal Title

      Prostaglandins Leukot Essent Fatty Acids

      Volume: 91 Issue: 4 Pages: 119-127

    • DOI

      10.1016/j.plefa.2014.07.015

    • NAID

      120006938650

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuroprotective Effect of Madecassoside Evaluated using Amyloid β1-42-mediated in vitro and in vivo Alzheimer’s disease Models.2014

    • Author(s)
      Abdullah Al Mamun, Michio Hashimoto, Masanori Katakura, Kentaro Matsuzaki, Shahdat Hossain, Hiroyuki Arai, Osamu Shido.
    • Journal Title

      International Journal of Indigenous Medicinal Plants.

      Volume: 47 Pages: 1669-1682

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Beneficial effects of perilla oil and brain training intervention on cognitive function in elderly Japanese.2017

    • Author(s)
      Michio Hashimoto, Yamashita Kazuya, Kentaro Matsuzaki, Setsushi Kato, Osamu Shido
    • Organizer
      21st International Association of Gerontology and Geriatrics World Congress
    • Place of Presentation
      San francisco, USA
    • Year and Date
      2017-07-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生体内における脂肪酸由来代謝物の新展開2017

    • Author(s)
      橋本道男
    • Organizer
      第101回尾道市医師会生活習慣病関連講演会
    • Place of Presentation
      尾道、ホテルグリーンヒル尾道
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 脳・神経機能維持とn-3系脂肪酸2017

    • Author(s)
      橋本道男
    • Organizer
      第90回日本薬理学会年会シンポジウム
    • Place of Presentation
      長崎、長崎ブルックホール
    • Year and Date
      2017-03-15
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] エゴマ油摂取と脳トレによる精神・神経機能への影響を検証するヒト介入試験-中間報告2016

    • Author(s)
      橋本道男、山下一也、牛尾 巧、松崎健太郎、伊藤智子、加藤真紀、大野美穂、加藤節司、黒崎康明、紫藤 治
    • Organizer
      第35回日本認知症学会学術集会
    • Place of Presentation
      東京、東京国際フォーラム
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] 七田式脳トレーニング法による健常高齢者認知機能への影響2016

    • Author(s)
      伊藤智子、加藤真紀、佐藤公子、山下一也、橋本道男、牛尾 巧、黒崎康明
    • Organizer
      第35回日本認知症学会学術集会
    • Place of Presentation
      東京、東京国際フォーラム
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
  • [Presentation] 「エゴマ」を使って街づくりをやろう2016

    • Author(s)
      橋本道男
    • Organizer
      鳥取実業娯楽部11月勉強会
    • Place of Presentation
      鳥取市、鳥取商工会議所
    • Year and Date
      2016-11-14
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 食、とくにω-3系脂肪酸による認知症予防と認知症患者への介護負担の軽減2016

    • Author(s)
      橋本道男
    • Organizer
      第6回日本認知症予防学会学術大会ランチョンセミナー
    • Place of Presentation
      仙台市、東北大学百周年記念会館 川内萩ホール
    • Year and Date
      2016-09-23
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] DHA強化食品摂取による認知機能向上効果に関する高齢者レスポンダーの栄養学的特長2016

    • Author(s)
      橋本道男、山下一也、加藤節司、大野美穂、田邊洋子、紫藤 治
    • Organizer
      日本脂質栄養学会第25回大会
    • Place of Presentation
      秋田市、秋田市にぎわい交流館AU(あう)
    • Year and Date
      2016-09-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 生活習慣病、とくに食の改善で防ぐ認知症2016

    • Author(s)
      橋本道男
    • Organizer
      東邦大学医療センター佐倉病院市民公開講座
    • Place of Presentation
      佐倉市、東邦大学医療センター佐倉病院
    • Year and Date
      2016-05-14
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Omega-3 polyunsaturated fatty acids and cognitive function2016

    • Author(s)
      Michio Hashimoto
    • Organizer
      The 42nd Annual Meeting and Conference of Nutrition Society of Taiwan
    • Place of Presentation
      Taipei, Republic China
    • Year and Date
      2016-04-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 食、とくにω3系脂肪酸摂取による認知症予防と介護者負担軽減効果2016

    • Author(s)
      橋本道男
    • Organizer
      フード・フォーラム・つくば 冬の例会
    • Place of Presentation
      つくば市、つくば国際会議場
    • Year and Date
      2016-01-12
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] ω-3系脂肪酸による認知症予防2015

    • Author(s)
      橋本道男、片倉賢紀、加藤節司、田邊洋子
    • Organizer
      第13回日本機能性食品医用学会総会
    • Place of Presentation
      福岡市、福岡大学病院メディカルホール
    • Year and Date
      2015-12-12
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 食と認知機能低下抑制2015

    • Author(s)
      橋本道男
    • Organizer
      応用脳科学コンソーシアム ブレインフードワークショップ第2回
    • Place of Presentation
      東京、AP東京丸の内
    • Year and Date
      2015-11-13
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 科学的エビデンスにもとづく「エゴマ」の魅力2015

    • Author(s)
      橋本道男
    • Organizer
      日本エゴマの会
    • Place of Presentation
      名古屋市、ウィルあいち愛知県女性総合センター
    • Year and Date
      2015-10-06
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] エゴマ油の精神・神経機能への影響とα-リノレン酸代謝を検証するヒト介入試験2015

    • Author(s)
      橋本道男、加藤節司、田邊洋子、片倉賢紀、紫藤 治
    • Organizer
      第34回日本認知症学会学術集会
    • Place of Presentation
      青森市、リンクステーションホール青森
    • Year and Date
      2015-10-02
    • Related Report
      2015 Research-status Report
  • [Presentation] 加圧加工玄米の摂取によるin vivo認知機能改善効果2015

    • Author(s)
      奥田充顕、藤田有紀、杉本八郎、橋本道男、勝部拓矢、田畑光正、吉野勝美
    • Organizer
      第5回日本認知症予防学会学術集会
    • Place of Presentation
      神戸市、神戸国際会議場
    • Year and Date
      2015-09-25
    • Related Report
      2015 Research-status Report
  • [Presentation] ω-3系脂肪酸の多面的効果と医療応用2015

    • Author(s)
      橋本道男
    • Organizer
      第4回岡山県精神科認知症懇話会
    • Place of Presentation
      岡山市、岡山赤十字病院
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 居住系施設入居高齢者への栄養と運動による介入試験でわかったこと2015

    • Author(s)
      橋本道男
    • Organizer
      邑智郡医師会特別講演会
    • Place of Presentation
      邑智郡川本町、ふるさと悠々会館
    • Year and Date
      2015-09-06
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 加齢ラットにおけるn-3系脂肪酸による空間認知機能改善効果と脳内多価不飽和脂肪酸代謝産物との関連性2015

    • Author(s)
      橋本道男、片倉賢紀、田邊洋子、Abdullah Al Mamun、有田 誠、紫藤 治
    • Organizer
      日本脂質栄養学会第24回大会
    • Place of Presentation
      佐賀市、ホテルグランデはがくれ
    • Year and Date
      2015-08-28
    • Related Report
      2015 Research-status Report
  • [Presentation] 島根県隠岐在住高齢者の精神神経機能と赤血球膜脂肪酸組成との関連性:Shimane CoHRE Study2015

    • Author(s)
      片倉賢紀、橋本道男、田邊洋子、山口修平、並河 徹、塩飽邦憲、紫藤 治
    • Organizer
      日本脂質栄養学会第24回大会
    • Place of Presentation
      佐賀市、ホテルグランデはがくれ
    • Year and Date
      2015-08-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Relationship between cognitive function and bone metabolism in elderly Japanese.2015

    • Author(s)
      Michio Hashimoto, Ichie Matsumoto, Yoko Tanabe, Masanori Katakura, Abdullah Al Mamun, Kazuya Yamashita, Setsushi Kato, Osamu Shido
    • Organizer
      Alzheimer's Association International Conference (AAIC) 2015
    • Place of Presentation
      Washington Convention Center, Washington, D.C., USA
    • Year and Date
      2015-07-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of dietary n-3 PUFA intervention on cognitive function and mental health in Japanese oldest-elderly with dementia2015

    • Author(s)
      Setsushi Kato, Michio Hashimoto, Miho Ohno, Masanori Katakura, Yoko Tanabe, Shuhei Yamaguchi, Osamu Shido
    • Organizer
      Alzheimer's Association International Conference (AAIC) 2015
    • Place of Presentation
      Washington Convention Center, Washington, D.C., USA
    • Year and Date
      2015-07-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] ω‐3系脂肪酸の多面的作用と医療応用について2015

    • Author(s)
      橋本道男
    • Organizer
      ω‐3PUFA Symposium
    • Place of Presentation
      渋谷、セルリアンタワー東急ホテル
    • Year and Date
      2015-07-15
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] ω‐3系脂肪酸の多面的作用と医療応用について2015

    • Author(s)
      橋本道男
    • Organizer
      第15回出雲臨床内科研究会
    • Place of Presentation
      出雲市、出雲医師会館
    • Year and Date
      2015-07-14
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Associated with neuropsychiatric functions and erythrocyte membrane fatty acid composition of the elderly: Shimane COHRE Study.2015

    • Author(s)
      Masanori Katakura, Michio Hashimoto, Yoko Tanabe, Shuhei Yamaguchi, Toru Nabika, Kuninori Shiwaku, Osamu Shido.
    • Organizer
      12th Asian Congress of Nutrition (ACN2015)
    • Place of Presentation
      Yokohama, PACIFICO Yokohama Convention Complex, Japan,
    • Year and Date
      2015-05-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 栄養・運動と認知症予防2015

    • Author(s)
      橋本道男
    • Organizer
      第20回中・四国老年期認知症研究会
    • Place of Presentation
      岡山国際交流センター
    • Year and Date
      2015-04-25
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] ω‐3系脂肪酸の多面的効果と医療応用2015

    • Author(s)
      橋本道男
    • Organizer
      第6回雲南脳疾患懇話会
    • Place of Presentation
      雲南市、仁多カルチャープラザ
    • Year and Date
      2015-04-16
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 高齢者の精神・神経機能の経時変化と食事栄養成分摂取量の関連性を検討する画像解析法の確立2015

    • Author(s)
      橋本道男、大野美穂、井上佳恵、田邊洋子、片倉賢紀、川端輝江、加藤節司、紫藤 治、香川靖雄
    • Organizer
      第18回日本病態栄養学会年次学術集会
    • Place of Presentation
      京都市、京都国際会議場
    • Year and Date
      2015-01-10 – 2015-01-11
    • Related Report
      2014 Research-status Report
  • [Presentation] n-3系脂肪酸摂取による高齢者向けの居住系介護施設等入居者の認知機能・情動への影響2014

    • Author(s)
      橋本道男、山口修平、加藤節司、田邊洋子、片倉賢紀、大野美穂、椎名康彦、紫藤 治
    • Organizer
      第33回日本認知症学会学術集会
    • Place of Presentation
      横浜市、パシフィコ横浜会議センター
    • Year and Date
      2014-11-29 – 2014-12-01
    • Related Report
      2014 Research-status Report
  • [Presentation] 高齢者の認知機能と介護負担におよぼすn-3系脂肪酸と運動の影響 第2報2014

    • Author(s)
      飯田晃子、加藤節司、佐々木美智子、大野美穂、大倉英久、橋本道男、小黒浩明、山口修平
    • Organizer
      第22回日本慢性期医療学会
    • Place of Presentation
      熊本市、市民会館崇城大学ホール
    • Year and Date
      2014-11-20 – 2014-11-21
    • Related Report
      2014 Research-status Report
  • [Presentation] Madecassoside, a major active compound of Centella asistica Leaf extract, protects amyloid β1-42-mediated neurotoxicity in vitro and in vivo.2014

    • Author(s)
      Michio Hashimoto, Abdullah Al Mamun, Masanori Katakura, Osamu Shido.
    • Organizer
      The 3rd International Conference on Nutraceutical and Cosmetic Sciences (3rd ICNaCS) 2014
    • Place of Presentation
      keio PLAZA HOTEL Tokyo, Tokyo, Japan,
    • Year and Date
      2014-11-11 – 2014-11-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Omega-3 fatty acids protect from renal dysfunctions by increasing docosahexaenoic acid-derived metabolite levels in SHR.Cg-Lepr(cp)/NDmcr rats, a metabolic syndrome model.2014

    • Author(s)
      Masanori Katakura, Michio Hashimoto, Abdullah Al Mamun, Makoto Arita, Osamu Shido.
    • Organizer
      The 3rd International Conference on Nutraceutical and Cosmetic Sciences (3rd ICNaCS) 2014
    • Place of Presentation
      keio PLAZA HOTEL Tokyo, Tokyo, Japan,
    • Year and Date
      2014-11-11 – 2014-11-12
    • Related Report
      2014 Research-status Report
  • [Presentation] ラット培養神経幹細胞の分化に対する多価不飽和脂肪酸合成酵素の役割2014

    • Author(s)
      片倉賢紀、橋本道男、奥井俊之、松崎健太郎、杉本直俊、紫藤 治
    • Organizer
      第66回日本生理学会中国四国地方会
    • Place of Presentation
      高松市、高松シンボルタワータワー棟
    • Year and Date
      2014-11-01 – 2014-11-02
    • Related Report
      2014 Research-status Report
  • [Presentation] 高齢者居住系施設における入居超高齢者の精神・神経機能と介護者負担度に及ぼすn-3系脂肪酸長期摂取の影響2014

    • Author(s)
      橋本道男、加藤節司、紫藤 治、山口修平
    • Organizer
      第11回認知症サプリメント研究会
    • Place of Presentation
      品川、AP品川
    • Year and Date
      2014-10-04
    • Related Report
      2014 Research-status Report
  • [Presentation] 高齢者向けの居住系介護施設等入居者の認知機能と介護者負担におよぼすn-3系脂肪酸と運動の影響-その2 12ヵ月間の介入試験成果2014

    • Author(s)
      橋本道男、加藤節司、山口修平、田邊洋子、片倉賢紀、大野美穂、椎名康彦、大倉英久、佐々木祐輔、松井禮子、岩野智栄美、下田友子、笠井宏美、紫藤 治
    • Organizer
      日本脂質栄養学会第23回大会
    • Place of Presentation
      東京、東京国際交流会館
    • Year and Date
      2014-08-29 – 2014-08-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 地域在住一般高齢者の認知機能に対するエゴマ油を使用した地中海式食事の効果2014

    • Author(s)
      山下一也、松本亥智江、田邊洋子、加藤節司、大野美穂、橋本道男
    • Organizer
      日本脂質栄養学会第23回大会
    • Place of Presentation
      東京、東京国際交流会館
    • Year and Date
      2014-08-29 – 2014-08-30
    • Related Report
      2014 Research-status Report
  • [Presentation] n-3多価不飽和脂肪酸による腎臓保護作用-メタボリックシンドロームモデルラットを用いた検討-2014

    • Author(s)
      片倉賢紀、橋本道男、井上隆之、田邊洋子、Abdullah Al Mamun、有田 誠、紫藤 治
    • Organizer
      日本脂質栄養学会第23回大会
    • Place of Presentation
      東京、東京国際交流会館
    • Year and Date
      2014-08-29 – 2014-08-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 科学的エビデンスに基ずくエゴマ(油)の魅力2014

    • Author(s)
      橋本道男
    • Organizer
      平成26年度「油化学シンポジウム in 広島」
    • Place of Presentation
      東広島市、近畿大学工学部 広島キャンパス
    • Year and Date
      2014-07-12
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Improvement of age-related cognitive decline by prescription n-3 fatty acids, but not EPA alone, is associated with increases of DHA-derived docosanoids and decreases of ARA-derived eicosanoids in rat brain.2014

    • Author(s)
      Michio Hashimoto, Masanori Katakura, Yoko Tanabe, Abdula Al Mamun, Takayuki Inoue, Makoto Arita, Osamu Shido
    • Organizer
      11th Congress of the International Society for the Study of Fatty Acids and Lipids.
    • Place of Presentation
      Stockholm, Sweden,
    • Year and Date
      2014-06-28 – 2014-07-02
    • Related Report
      2014 Research-status Report
  • [Presentation] Effects of docosahexaenoic acid intervention on cognitive function and mental health in Japanese oldest-elderly with dementia.2014

    • Author(s)
      Setushi Kato, Michio Hashimoto, Miho Ohno, Masanori Katakura, Yoko Tanabe, Shuhei Yamaguchi, Yasuhiko Shiina, Osamu Shido.
    • Organizer
      11th Congress of the International Society for the Study of Fatty Acids and Lipids.
    • Place of Presentation
      Stockholm, Sweden,
    • Year and Date
      2014-06-28 – 2014-07-02
    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] 高齢者用加工食品2017

    • Inventor(s)
      吉野勝美、橋本道男、松田辰志、ほか5名
    • Industrial Property Rights Holder
      吉野勝美、橋本道男、松田辰志、ほか5名
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-059204
    • Filing Date
      2017-03-24
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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