Attempts of tailor-made nutrition by sub-analysis of human interventional study aimed at establishing preventive methods for dementia/depression
| Project/Area Number |
26500008
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrated Nutrition Science
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| Research Institution | Shimane University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
片倉 賢紀 城西大学, 薬学部, 准教授 (40383179)
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| Co-Investigator(Renkei-kenkyūsha) |
KAGAWA Yasuo 女子栄養大学, 栄養学部, 教授 (30048962)
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| Research Collaborator |
KATO Setsushi 仁寿会, 加藤病院, 院長
ONO Miho 仁寿会, 加藤病院, 管理栄養士
OKUI Toshiyuki 島根大学, 医学部, 特別研究協力員
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 認知症予防 / 高齢者介入試験 / コホート疫学研究 / 魚油 / 超高水圧加圧玄米 / やる気とうつ予防 / テーラーメイド栄養 / 機能性食品の開発 / 高齢者 / 認知機能維持 / 骨密度維持 / エゴマ油 / 超高水圧加工玄米 / ヒト介入試験 / 認知機能 / 情動 / 縦断的疫学研究 / 脳トレ / ω3系脂肪酸 / 遺伝子多型 |
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| Outline of Final Research Achievements |
Epidemiological survey data analysis of the Shimane COHRE Study in 2012 and 2014 suggested that motivation of female elderly people is higher than that of male elderly people, and also that an increase in intake frequency of blue fish alleviates depression and improves motivation It was done.
In a healthy elderly intervention trial, ingesting ultrahigh pressure pressurized brown rice for 12 months strengthened the bones of the elderly and improved their motivation. Their interventional trial of combination of perilla oil ingestion and brain training also improved their frontal lobe function. Furthermore, dietary docosahexaenoic acid intervention for 12 months protect against age-related cognitive decline, and also improve apathy and caregiver burden for the oldest-elderly people with cognitive impairment, such as dementia.
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Report
(4 results)
Research Products
(63 results)
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[Journal Article] Alterations in the Levels of Amyloid-β, Phospholipid Hydroperoxide, and Plasmalogen in the Blood of Patients with Alzheimer's Disease: Possible Interactions between Amyloid-β and These Lipids.2015
Author(s)
Yamashita S, Kiko T, Fujiwara H, Hashimoto M, Nakagawa K, Kinoshita M, Furukawa K, Arai H, Miyazawa T
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Journal Title
J Alzheimers Dis.
Volume: 50
Issue: 2
Pages: 527-537
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] ω-3系脂肪酸による認知症予防2015
Author(s)
橋本道男、片倉賢紀、加藤節司、田邊洋子
Organizer
第13回日本機能性食品医用学会総会
Place of Presentation
福岡市、福岡大学病院メディカルホール
Year and Date
2015-12-12
Related Report
Invited
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[Presentation] Relationship between cognitive function and bone metabolism in elderly Japanese.2015
Author(s)
Michio Hashimoto, Ichie Matsumoto, Yoko Tanabe, Masanori Katakura, Abdullah Al Mamun, Kazuya Yamashita, Setsushi Kato, Osamu Shido
Organizer
Alzheimer's Association International Conference (AAIC) 2015
Place of Presentation
Washington Convention Center, Washington, D.C., USA
Year and Date
2015-07-18
Related Report
Int'l Joint Research
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[Presentation] 栄養・運動と認知症予防2015
Author(s)
橋本道男
Organizer
第20回中・四国老年期認知症研究会
Place of Presentation
岡山国際交流センター
Year and Date
2015-04-25
Related Report
Invited
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[Presentation] Improvement of age-related cognitive decline by prescription n-3 fatty acids, but not EPA alone, is associated with increases of DHA-derived docosanoids and decreases of ARA-derived eicosanoids in rat brain.2014
Author(s)
Michio Hashimoto, Masanori Katakura, Yoko Tanabe, Abdula Al Mamun, Takayuki Inoue, Makoto Arita, Osamu Shido
Organizer
11th Congress of the International Society for the Study of Fatty Acids and Lipids.
Place of Presentation
Stockholm, Sweden,
Year and Date
2014-06-28 – 2014-07-02
Related Report
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