Elucidation of relationships between sleep apnea and fluid shift in heart failure

• Project/Area Number: 26507010
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 睡眠科学
• Research Institution: Juntendo University
• Principal Investigator: Kasai Takatoshi 順天堂大学, 医学(系)研究科(研究院), 准教授 (60465036)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 睡眠医学 / 心不全 / 睡眠呼吸障害 / 急性非代償性心不全 / 僧房弁閉鎖不全 / 水分シフト / 睡眠時無呼吸

Outline of Final Research Achievements

Coexistence of sleep apnea (SA), a treatable comorbidity, leads poor prognostic in patients with heart failure (HF). Reportedly, fluid redistribution from the legs to the upper body during sleep can contribute to the pathogenesis of SA in HF patients. We conducted investigations to further elucidate relationships between SA and fluid shift in HF. We found and reported that in patients with acute HF, volume of fluid shift correlated with severity of SA, and that following standard treatment of acute HF, SA was alleviated in association with reductions of fluid shift volume. In addition, we found and reported that in patients with mitral regurgitation, volume of fluid shift correlated with severity of SA, and that following surgery for mitral regurgitation, SA severity changed in association with changes in fluid shift volume. Further investigation whether cardiac rehabilitation can alleviate SA in association with reductions in fluid shift volume is on ongoing.

Research Products

• [Journal Article] Fluid Retention and Rostral Fluid Shift in Sleep-Disordered Breathing. (2016)
  • Author(s): Takatoshi Kasai
  • Journal Title: Current Hypertension Reviews Volume: 12 Pages: 32-42
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Fluid retention and rostral fluid shift in sleep-disordered breathing. (2016)
  • Author(s): Kasai T.
  • Journal Title: Curr Hypertens Rev. Volume: 12 Pages: 32-42
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Comparison of clinical features and polysomnographic findings between men and women with sleep apnea. (2016)
  • Author(s): Yamakoshi S, Kasai T, Tomita Y, Takaya H, Kasagi, S, Kawabata M, Narui K, Setoguchi Y.
  • Journal Title: J Thorac Dis. Volume: 8 Pages: 145-151
  • Peer Reviewed / Open Access
• [Journal Article] Impact of sleep-disordered breathing on long-term outcomes in patients with acute coronary syndrome who have undergone primary percutaneous coronary intervention. (2016)
  • Author(s): Mazaki T, Kasai T, Yokoi H, Kuramitsu S, Yamaji K, Morinaga T, Masuda H, Shirai S, Ando K.
  • Journal Title: J Am Heart Assoc. Volume: In press
  • Peer Reviewed / Open Access
• [Journal Article] Overnight effects of obstructive sleep apnea and its treatment on stroke volume in patients with heart failure. (2015)
  • Author(s): 6.Kasai T, Yumino D, Redolfi S, Su MC, Ruttanaumpawan P, Mak S, Newton GE, Floras JS, Bradley TD.
  • Journal Title: Can J Cardiol Volume: 31 Issue: 7 Pages: 832-838
  • DOI: 10.1016/j.cjca.2015.01.001
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Sleep-disordered breathing in patients with polycystic liver and kidney disease referred for transcatheter arterial embolization. (2015)
  • Author(s): Sumida K, Hoshino J, Suwabe T, Kasai T, Hayami N, Mise K, Kawada M, Imafuku A, Hiramatsu R, Hasegawa E, Yamanouchi M, Sawa N, Narui K, Takaichi K, Ubara Y.
  • Journal Title: Clin J Am Soc Nephrol Volume: 10 Issue: 6 Pages: 949-956
  • DOI: 10.2215/cjn.06930714
  • Peer Reviewed
• [Journal Article] Effectiveness of adaptive servo-ventilation. (2015)
  • Author(s): Tomita Y, Kasai T.
  • Journal Title: World J Respirol Volume: 5 Issue: 2 Pages: 112-125
  • DOI: 10.5320/wjr.v5.i2.112
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between sleep disordered breathing and diabetic retinopathy: Analysis of 136 patients with diabetes. (2015)
  • Author(s): Nishimura A, Kasai T, Tamura H, Yamato A, Yasuda D, Nagasawa K, Okubo M, Narui K, Mori Y.
  • Journal Title: Diabetes Res Clin Pract. Volume: 109 Issue: 2 Pages: 306-311
  • DOI: 10.1016/j.diabres.2015.05.015
  • Peer Reviewed
• [Journal Article] Bradyarrhythmias may induce central sleep apnea in a patient with obstructive sleep apnea. (2015)
  • Author(s): Suda S, Kasai T, Kato M, Kawana F, Kato T, Ichikawa R, Hayashi H, Kawata T, Sekita G, Itoh S, Daida H.
  • Journal Title: Heart Vessels Volume: 30 Issue: 4 Pages: 554-557
  • DOI: 10.1007/s00380-014-0511-x
  • Peer Reviewed
• [Journal Article] The effect of adaptive servo-ventilation on dyspnoea, haemodynamic parameters and plasma catecholamine concentrations in acute cardiogenic pulmonary oedema. (2015)
  • Author(s): Nakano S, Kasai T, Tanno J, Sugi K, Muramatsu T, Senbonmatsu T, Nishimura S.
  • Journal Title: Eur Heart J Acute Cardiovasc Care. Volume: 4 Issue: 4 Pages: 305-315
  • DOI: 10.1177/2048872614549103
  • Peer Reviewed
• [Journal Article] Altered breathing syndrome in heart failure: newer insights and treatment options. (2015)
  • Author(s): Tomita Y, Kasai T, Kisaka T, Rossiter HB, Kihara Y, Wasserman K, Daida H.
  • Journal Title: Curr Heart Fail Rep. Volume: 12(2) Issue: 2 Pages: 158-65
  • DOI: 10.1007/s11897-014-0250-4
  • Peer Reviewed
• [Journal Article] The upper airway in sleep disordered-breathing. (2014)
  • Author(s): Taranto Montemurro L, Kasai T
  • Journal Title: Minerva Med Volume: 105 Pages: 23-40
• [Journal Article] Craniofacial anatomical risk factors in men with obstructive sleep apnea and heart failure: a pilot study. (2014)
  • Author(s): Inoshita A, Kasai T, Takahashi M, Inoshita H, Kasagi S, Kawana F, Ishiwata S, Ohno M, Yamaguchi T, Narui K, Ikeda K.
  • Journal Title: Sleep Breath Volume: 18 Issue: 2 Pages: 439-445
  • DOI: 10.1007/s11325-013-0906-4
  • Peer Reviewed
• [Journal Article] Immediate changes in severity and type of sleep-disordered breathing following mitral repair. (2014)
  • Author(s): Shimada A, Kasai T, Suda S, Kato T, Murata A, Kato M, Oishi A, Yamamoto T, Kuwaki K, Inaba H, Daida H, Amano A.
  • Journal Title: Exp Clin Cardiol Volume: 20 Pages: 145-148
  • Peer Reviewed / Open Access
• [Journal Article] A Randomized, double cross-over study to investigate the influence of saline infusion on sleep apnea severity in men. (2014)
  • Author(s): Yadollahi A, Gabriel JM, White LH, Taranto Montemurro L, Kasai T, Bradley TD.
  • Journal Title: Sleep Volume: 37 Issue: 10 Pages: 1699-1705
  • DOI: 10.5665/sleep.4084
  • Peer Reviewed / Open Access
• [Journal Article] Influence of rostral fluid shift on upper airway size and mucosal water content. (2014)
  • Author(s): Kasai T, Motwani SS, Elias RM, Yanagisawa N, Spiller N, Paul N, Bradley TD.
  • Journal Title: J Clin Sleep Med Volume: 10 Issue: 10 Pages: 1069-1074
  • DOI: 10.5664/jcsm.4102
  • Peer Reviewed / Open Access
• [Journal Article] Positive airway pressure therapy for heart failure. (2014)
  • Author(s): 17.Kato T, Suda S, Kasai T.
  • Journal Title: World J Cardiol Volume: 6 Issue: 11 Pages: 1175-1191
  • DOI: 10.4330/wjc.v6.i11.1175
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Bradyarrhythmias may induce central sleep apnea in a patient with obstructive sleep apnea. (2014)
  • Author(s): Suda S, Kasai T, Kato M, Kawana F, Kato T, Ichikawa R, Hayashi H, Kawata T, Sekita G, Itoh S, Daida H.
  • Journal Title: Heart Vessels Volume: April 19
  • Peer Reviewed
• [Presentation] Relationship between overnight fluid shift and severity of sleep apnea in patients with moderate-to-severe mitral regurgitation and preserved ejection fraction (2017)
  • Author(s): 村田梓、葛西隆敏ら
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2017-03-17
• [Presentation] Relationship between overnight rostral fluid shift and severity of central sleep apnea in hospitalized heart failure patients following acute decompensation (2016)
  • Author(s): Azusa Murata, Takatoshi Kasai, et al.
  • Organizer: CardioSleep Conference 2016
  • Place of Presentation: プラハ、チェコ
  • Year and Date: 2016-04-29
  • Int'l Joint Research
• [Presentation] Relationship between overnight rostral fluid shift and severity of central sleep apnea in hospitalized heart failure patients following acute decompensation (2016)
  • Author(s): Murata A, Kasai T, Kato T, Suda S, Yatsu S, Matsumoto H, Hiki M, Daida H.
  • Organizer: CardioSleep 2016
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 2016-04-29
  • Int'l Joint Research
• [Presentation] 夜間の下肢からの体液移動と睡眠呼吸障害の重症度の関係性 (2015)
  • Author(s): 加藤隆生、葛西隆敏、谷津翔一朗、村田梓、須田翔子、比企優、宮崎哲朗、高木篤俊、代田浩之
  • Organizer: 第63回日本心臓病学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2015-09-17
• [Presentation] Relationship between overnight rostral fluid shift and severity of sleep disordered breathing. (2015)
  • Author(s): Suda S, Kasai T, Yatsu S, Murata A, Kato T, Hiki M, Miyazaki T, Takagi A, Daida H.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-14
• [Presentation] 14.Postgraduate course: Respiratory Neurobiology and sleep. Sleep apnea and heart failure. (2014)
  • Author(s): Kasai T.
  • Organizer: 19th Congress of Asia Pacific Society of Respirology.
  • Place of Presentation: Bali, Indonesia
  • Year and Date: 2014-11-13 – 2014-11-16
  • Invited
• [Presentation] 13.Assembly of Respiratory Neurobiology and Sleep Assembly Session 1: Advances in OSA Pathophysiology, Comorbidity and Treatment. Fluid Shift in patients with the sleep disordered breathing. (2014)
  • Author(s): Kasai T.
  • Organizer: 19th Congress of Asia Pacific Society of Respirology.
  • Place of Presentation: Bali, Indonesia
  • Year and Date: 2014-11-13 – 2014-11-16
  • Invited
• [Presentation] Change in type of sleep-disordered breathing from predominant central to obstructive sleep apnea following coronary artery bypass grafting. (2014)
  • Author(s): Yatsu S, Kasai T, Murata A, Kato T, Suda S, Hiki M, Matsunaga E, Miyazaki T, Takagi A, Daida H.
  • Organizer: 第18回日本心不全学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-10-10 – 2014-10-12
• [Presentation] Pulmonary hypertension associated with obesity hypoventilation syndrome: a case report (2014)
  • Author(s): Takasu K, Matsumoto H, Nishiyama H, Kasai T, Miyazaki T, Takagi A, Konishi H, Ohmura H, Miyauchi K, Daida H.
  • Organizer: 第18回日本心不全学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-10-10 – 2014-10-12
• [Presentation] Influences of sleep-disordered breathing and its treatment by positive airway pressure on mortality and rehospitalization in patients with systolic heart failure following acute decompensation. (2014)
  • Author(s): Suda S, Kasai T, Murata A, Yatsu S, Kato T, Hiki M, Daida H.
  • Organizer: American Thoracic Society International Conference 2014
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-05-16 – 2014-05-21