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Elucidation of relationships between sleep apnea and fluid shift in heart failure

Research Project

Project/Area Number 26507010
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field 睡眠科学
Research InstitutionJuntendo University

Principal Investigator

Kasai Takatoshi  順天堂大学, 医学(系)研究科(研究院), 准教授 (60465036)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords睡眠医学 / 心不全 / 睡眠呼吸障害 / 急性非代償性心不全 / 僧房弁閉鎖不全 / 水分シフト / 睡眠時無呼吸
Outline of Final Research Achievements

Coexistence of sleep apnea (SA), a treatable comorbidity, leads poor prognostic in patients with heart failure (HF). Reportedly, fluid redistribution from the legs to the upper body during sleep can contribute to the pathogenesis of SA in HF patients. We conducted investigations to further elucidate relationships between SA and fluid shift in HF. We found and reported that in patients with acute HF, volume of fluid shift correlated with severity of SA, and that following standard treatment of acute HF, SA was alleviated in association with reductions of fluid shift volume. In addition, we found and reported that in patients with mitral regurgitation, volume of fluid shift correlated with severity of SA, and that following surgery for mitral regurgitation, SA severity changed in association with changes in fluid shift volume. Further investigation whether cardiac rehabilitation can alleviate SA in association with reductions in fluid shift volume is on ongoing.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (28 results)

All 2017 2016 2015 2014

All Journal Article (18 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 17 results,  Acknowledgement Compliant: 3 results,  Open Access: 7 results) Presentation (10 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results)

  • [Journal Article] Fluid Retention and Rostral Fluid Shift in Sleep-Disordered Breathing.2016

    • Author(s)
      Takatoshi Kasai
    • Journal Title

      Current Hypertension Reviews

      Volume: 12 Pages: 32-42

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Fluid retention and rostral fluid shift in sleep-disordered breathing.2016

    • Author(s)
      Kasai T.
    • Journal Title

      Curr Hypertens Rev.

      Volume: 12 Pages: 32-42

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Comparison of clinical features and polysomnographic findings between men and women with sleep apnea.2016

    • Author(s)
      Yamakoshi S, Kasai T, Tomita Y, Takaya H, Kasagi, S, Kawabata M, Narui K, Setoguchi Y.
    • Journal Title

      J Thorac Dis.

      Volume: 8 Pages: 145-151

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of sleep-disordered breathing on long-term outcomes in patients with acute coronary syndrome who have undergone primary percutaneous coronary intervention.2016

    • Author(s)
      Mazaki T, Kasai T, Yokoi H, Kuramitsu S, Yamaji K, Morinaga T, Masuda H, Shirai S, Ando K.
    • Journal Title

      J Am Heart Assoc.

      Volume: In press

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Overnight effects of obstructive sleep apnea and its treatment on stroke volume in patients with heart failure.2015

    • Author(s)
      6.Kasai T, Yumino D, Redolfi S, Su MC, Ruttanaumpawan P, Mak S, Newton GE, Floras JS, Bradley TD.
    • Journal Title

      Can J Cardiol

      Volume: 31 Issue: 7 Pages: 832-838

    • DOI

      10.1016/j.cjca.2015.01.001

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Sleep-disordered breathing in patients with polycystic liver and kidney disease referred for transcatheter arterial embolization.2015

    • Author(s)
      Sumida K, Hoshino J, Suwabe T, Kasai T, Hayami N, Mise K, Kawada M, Imafuku A, Hiramatsu R, Hasegawa E, Yamanouchi M, Sawa N, Narui K, Takaichi K, Ubara Y.
    • Journal Title

      Clin J Am Soc Nephrol

      Volume: 10 Issue: 6 Pages: 949-956

    • DOI

      10.2215/cjn.06930714

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effectiveness of adaptive servo-ventilation.2015

    • Author(s)
      Tomita Y, Kasai T.
    • Journal Title

      World J Respirol

      Volume: 5 Issue: 2 Pages: 112-125

    • DOI

      10.5320/wjr.v5.i2.112

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between sleep disordered breathing and diabetic retinopathy: Analysis of 136 patients with diabetes.2015

    • Author(s)
      Nishimura A, Kasai T, Tamura H, Yamato A, Yasuda D, Nagasawa K, Okubo M, Narui K, Mori Y.
    • Journal Title

      Diabetes Res Clin Pract.

      Volume: 109 Issue: 2 Pages: 306-311

    • DOI

      10.1016/j.diabres.2015.05.015

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bradyarrhythmias may induce central sleep apnea in a patient with obstructive sleep apnea.2015

    • Author(s)
      Suda S, Kasai T, Kato M, Kawana F, Kato T, Ichikawa R, Hayashi H, Kawata T, Sekita G, Itoh S, Daida H.
    • Journal Title

      Heart Vessels

      Volume: 30 Issue: 4 Pages: 554-557

    • DOI

      10.1007/s00380-014-0511-x

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] The effect of adaptive servo-ventilation on dyspnoea, haemodynamic parameters and plasma catecholamine concentrations in acute cardiogenic pulmonary oedema.2015

    • Author(s)
      Nakano S, Kasai T, Tanno J, Sugi K, Muramatsu T, Senbonmatsu T, Nishimura S.
    • Journal Title

      Eur Heart J Acute Cardiovasc Care.

      Volume: 4 Issue: 4 Pages: 305-315

    • DOI

      10.1177/2048872614549103

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Altered breathing syndrome in heart failure: newer insights and treatment options.2015

    • Author(s)
      Tomita Y, Kasai T, Kisaka T, Rossiter HB, Kihara Y, Wasserman K, Daida H.
    • Journal Title

      Curr Heart Fail Rep.

      Volume: 12(2) Issue: 2 Pages: 158-65

    • DOI

      10.1007/s11897-014-0250-4

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] The upper airway in sleep disordered-breathing.2014

    • Author(s)
      Taranto Montemurro L, Kasai T
    • Journal Title

      Minerva Med

      Volume: 105 Pages: 23-40

    • Related Report
      2014 Research-status Report
  • [Journal Article] Craniofacial anatomical risk factors in men with obstructive sleep apnea and heart failure: a pilot study.2014

    • Author(s)
      Inoshita A, Kasai T, Takahashi M, Inoshita H, Kasagi S, Kawana F, Ishiwata S, Ohno M, Yamaguchi T, Narui K, Ikeda K.
    • Journal Title

      Sleep Breath

      Volume: 18 Issue: 2 Pages: 439-445

    • DOI

      10.1007/s11325-013-0906-4

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Immediate changes in severity and type of sleep-disordered breathing following mitral repair.2014

    • Author(s)
      Shimada A, Kasai T, Suda S, Kato T, Murata A, Kato M, Oishi A, Yamamoto T, Kuwaki K, Inaba H, Daida H, Amano A.
    • Journal Title

      Exp Clin Cardiol

      Volume: 20 Pages: 145-148

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Randomized, double cross-over study to investigate the influence of saline infusion on sleep apnea severity in men.2014

    • Author(s)
      Yadollahi A, Gabriel JM, White LH, Taranto Montemurro L, Kasai T, Bradley TD.
    • Journal Title

      Sleep

      Volume: 37 Issue: 10 Pages: 1699-1705

    • DOI

      10.5665/sleep.4084

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of rostral fluid shift on upper airway size and mucosal water content.2014

    • Author(s)
      Kasai T, Motwani SS, Elias RM, Yanagisawa N, Spiller N, Paul N, Bradley TD.
    • Journal Title

      J Clin Sleep Med

      Volume: 10 Issue: 10 Pages: 1069-1074

    • DOI

      10.5664/jcsm.4102

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Positive airway pressure therapy for heart failure.2014

    • Author(s)
      17.Kato T, Suda S, Kasai T.
    • Journal Title

      World J Cardiol

      Volume: 6 Issue: 11 Pages: 1175-1191

    • DOI

      10.4330/wjc.v6.i11.1175

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Bradyarrhythmias may induce central sleep apnea in a patient with obstructive sleep apnea.2014

    • Author(s)
      Suda S, Kasai T, Kato M, Kawana F, Kato T, Ichikawa R, Hayashi H, Kawata T, Sekita G, Itoh S, Daida H.
    • Journal Title

      Heart Vessels

      Volume: April 19

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Relationship between overnight fluid shift and severity of sleep apnea in patients with moderate-to-severe mitral regurgitation and preserved ejection fraction2017

    • Author(s)
      村田梓、葛西隆敏ら
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Relationship between overnight rostral fluid shift and severity of central sleep apnea in hospitalized heart failure patients following acute decompensation2016

    • Author(s)
      Azusa Murata, Takatoshi Kasai, et al.
    • Organizer
      CardioSleep Conference 2016
    • Place of Presentation
      プラハ、チェコ
    • Year and Date
      2016-04-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Relationship between overnight rostral fluid shift and severity of central sleep apnea in hospitalized heart failure patients following acute decompensation2016

    • Author(s)
      Murata A, Kasai T, Kato T, Suda S, Yatsu S, Matsumoto H, Hiki M, Daida H.
    • Organizer
      CardioSleep 2016
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2016-04-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 夜間の下肢からの体液移動と睡眠呼吸障害の重症度の関係性2015

    • Author(s)
      加藤隆生、葛西隆敏、谷津翔一朗、村田梓、須田翔子、比企優、宮崎哲朗、高木篤俊、代田浩之
    • Organizer
      第63回日本心臓病学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2015-09-17
    • Related Report
      2015 Research-status Report
  • [Presentation] Relationship between overnight rostral fluid shift and severity of sleep disordered breathing.2015

    • Author(s)
      Suda S, Kasai T, Yatsu S, Murata A, Kato T, Hiki M, Miyazaki T, Takagi A, Daida H.
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-14
    • Related Report
      2015 Research-status Report
  • [Presentation] 14.Postgraduate course: Respiratory Neurobiology and sleep. Sleep apnea and heart failure.2014

    • Author(s)
      Kasai T.
    • Organizer
      19th Congress of Asia Pacific Society of Respirology.
    • Place of Presentation
      Bali, Indonesia
    • Year and Date
      2014-11-13 – 2014-11-16
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 13.Assembly of Respiratory Neurobiology and Sleep Assembly Session 1: Advances in OSA Pathophysiology, Comorbidity and Treatment. Fluid Shift in patients with the sleep disordered breathing.2014

    • Author(s)
      Kasai T.
    • Organizer
      19th Congress of Asia Pacific Society of Respirology.
    • Place of Presentation
      Bali, Indonesia
    • Year and Date
      2014-11-13 – 2014-11-16
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Change in type of sleep-disordered breathing from predominant central to obstructive sleep apnea following coronary artery bypass grafting.2014

    • Author(s)
      Yatsu S, Kasai T, Murata A, Kato T, Suda S, Hiki M, Matsunaga E, Miyazaki T, Takagi A, Daida H.
    • Organizer
      第18回日本心不全学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-10-10 – 2014-10-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Pulmonary hypertension associated with obesity hypoventilation syndrome: a case report2014

    • Author(s)
      Takasu K, Matsumoto H, Nishiyama H, Kasai T, Miyazaki T, Takagi A, Konishi H, Ohmura H, Miyauchi K, Daida H.
    • Organizer
      第18回日本心不全学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-10-10 – 2014-10-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Influences of sleep-disordered breathing and its treatment by positive airway pressure on mortality and rehospitalization in patients with systolic heart failure following acute decompensation.2014

    • Author(s)
      Suda S, Kasai T, Murata A, Yatsu S, Kato T, Hiki M, Daida H.
    • Organizer
      American Thoracic Society International Conference 2014
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-05-16 – 2014-05-21
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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