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Personal flow cytometry by ultra-compact high-spatial-resolution line spectroscopic imaging

Research Project

Project/Area Number 26560214
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionKagawa University

Principal Investigator

ISHIMARU Ichiro  香川大学, 工学部, 教授 (70325322)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords分光 / ハイパースペクトルカメラ / 高感度化 / 蛍光標識 / フーリエ分光 / 光圧力 / 光ピンセット / フローサイトメトリー / 空間的位相シフト法 / スナップショット / 細胞 / 手のひらサイズ / ラマン散乱 / フローサイトメトリ
Outline of Final Research Achievements

We proposed the snapshot-type Fourier spectroscopic imaging for smartphone. For spectroscopic components analysis, such as non-invasive blood glucose sensors, the diffuse reflection lights from internal human skins are very weak for conventional hyperspectral cameras, such as AOTF (Acousto-Optic Tunable Filter) type. For improving sensitivity of our spectroscopic imager, the wide-field-stop & beam-expansion method was proposed. We installed concave-cylindrical lens between the wider slit and objective lens as a beam expander. We successfully obtained the spectroscopic characters of hemoglobin from reflected lights from human fingers.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (14 results)

All 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (6 results) (of which Peer Reviewed: 5 results) Presentation (5 results) (of which Invited: 1 results) Book (1 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] ミュンヘン工科大学(ドイツ)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Built-in hyperspectral camera for smartphone in visible, near-infrared and middle-infrared lights region (second report): sensitivity improvement of Fourier-spectroscopic imaging to detect diffuse reflection lights from internal human tissues for healthcare sensors2016

    • Author(s)
      Natsumi Kawashima
    • Journal Title

      Proc. SPIE 9855, Next-Generation Spectroscopic Technologies IX

      Volume: 9855 Pages: 985505-985505

    • DOI

      10.1117/12.2223392

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Built-in hyperspectral camera for smartphone in visible, near-infrared and middle-infrared lights region (first report): trial products of beans-size Fourier-spectroscopic line-imager and feasibility experimental results of middle-infrared spectroscopic imaging2016

    • Author(s)
      Ichiro Ishimaru
    • Journal Title

      Proc. SPIE 9855, Next-Generation Spectroscopic Technologies IX

      Volume: 9855 Pages: 985504-985504

    • DOI

      10.1117/12.2223353

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ultra-compact hyperspectral camera for mid-infrared lights2016

    • Author(s)
      Ichiro Ishimaru
    • Journal Title

      Proc. of International Symposium on Optomechatronic Technology 2016(ISOT 2016)

      Volume: SS1-4

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extremely compact hyperspectral camera for drone and smartphone2016

    • Author(s)
      Ichiro ISHIMARU
    • Journal Title

      Proc. of 3rd International Workshop on Image Sensors and Imaging Systems (IWISS2016)

      Volume: 1 Pages: 264-267

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sensitivity improvement of one-shot Fourier spectroscopic imager for realization of noninvasive blood glucose sensors in smartphones2016

    • Author(s)
      Natsumi Kawashima
    • Journal Title

      Opt. Eng.

      Volume: 55 Issue: 11 Pages: 110506-110506

    • DOI

      10.1117/1.oe.55.11.110506

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 手のひらサイズの広視野分光イメージング装置2015

    • Author(s)
      市丸伊知郎
    • Journal Title

      OplusE

      Volume: 37 Pages: 181-185

    • Related Report
      2014 Research-status Report
  • [Presentation] 超小型中赤外分光イメージング装置(ハイパー2016

    • Author(s)
      石丸伊知郎
    • Organizer
      日本分析化学会第65年会(2016.9)
    • Place of Presentation
      北海道大学
    • Year and Date
      2016-09-23
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Built-in hyperspectral camera for smartphone in visible, near-infrared and middle-infrared lights region (2nd.report) - Sensitivity improvement of Fourier spectroscopic imaging to detect diffuse reflection lights from internal human tissues for healthcare sensors -2016

    • Author(s)
      Natsumi KAWASHIMA, Satsuki HOSONO, Ichiro ISHIMARU
    • Organizer
      Proc. of SPIE Defense and Commercial Sensing Conference 2016
    • Place of Presentation
      米国ボルティモア
    • Year and Date
      2016-04-17
    • Related Report
      2015 Research-status Report
  • [Presentation] 高感度分光イメージングによる液体セルや生体試料内部における全血の計測2016

    • Author(s)
      4.山本直幸,藤原 大,猪原大地,野郷孝介,吉田光宏,森 敬太,川嶋なつみ,西山 成,石丸伊知郎
    • Organizer
      2015年度精密工学会春季大会学術講演会
    • Place of Presentation
      東京理科大学
    • Year and Date
      2016-03-15
    • Related Report
      2015 Research-status Report
  • [Presentation] One-shot Fourier spectroscopic imager for healthcare sensors installed into smartphones2015

    • Author(s)
      5.Natsumi KAWASHIMA, Hiroyuki HIRAMATSU, Masaru Fujiwara, Akira NISHIYAMA, Kenji WADA, Ichiro ISHIMARU
    • Organizer
      Medical Optics & Spectroscopy 2015, The Japan Association of Medical Spectroscopy
    • Place of Presentation
      東京
    • Year and Date
      2015-12-10
    • Related Report
      2015 Research-status Report
  • [Presentation] Sensitivity enhancement of the one-shot Fourier spectroscopic imager for healthcare sensors installed into smartphones2015

    • Author(s)
      9.Natsumi Kawashima, Hiroyuki Hiramatsu, Masaru Fujiwara, Satsuki Hosono, Pradeep Abeygunawardhana, Akira Nishiyama, Kenji Wada and Ichiro Ishimaru
    • Organizer
      Optical & Photonics Japan 2015
    • Place of Presentation
      筑波大学東京キャンパス
    • Year and Date
      2015-10-15
    • Related Report
      2015 Research-status Report
  • [Book] 手のひらサイズの中赤外ハイパースペクトルカメラ2016

    • Author(s)
      石丸伊知郎
    • Total Pages
      7
    • Publisher
      化学工業
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 分光イメージングの高感度化に関する技術2015

    • Inventor(s)
      石丸伊知郎
    • Industrial Property Rights Holder
      石丸伊知郎
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-137321
    • Filing Date
      2015-07-08
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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