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Persistent luminescence nanoparticles applicable for in vivo imaging of cancer

Research Project

Project/Area Number 26560220
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionNara Medical University

Principal Investigator

Nishi Mayumi  奈良県立医科大学, 医学部, 教授 (40295639)

Co-Investigator(Kenkyū-buntansha) HORII Noriko  奈良県立医科大学, 医学部, 助教 (80433332)
Co-Investigator(Renkei-kenkyūsha) TAKI Masayasu  名古屋大学, 理学部, 特任准教授 (70378850)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords長残光蛍光ナノ粒子 / in vivo イメージング / 担癌マウス / 無侵襲 / 低毒性 / in vivoイメージング
Outline of Final Research Achievements

For developing the innovative probe of persistent luminescence nanoparticles applicable to medicine, we aimed at bioimaging without irradiation to visualize tumor cells in living animals. After transplanting human osteosarcoma (HOS) into subcutaneous of SCID mouse, antibody agaisnt HOS labeled with photactivated persistent luminescence nanoparticles was intravenously injected to this SCID mouse. We successfully peformed in vivo imaging of HOS by using photocouting system, IVIS Imaging System.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (30 results)

All 2016 2015 2014

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 4 results) Presentation (22 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] A new area of the mouse anterior hypothalamus involved in septohypothalamic circuit Interdisciplinary Inforamation Science2015

    • Author(s)
      Horii-Hayashi N, Sasagawa T, Nishi M
    • Journal Title

      Interdisciplinary Information Science

      Volume: 21 Pages: 243-251

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A newly identified mouse hypothalamic area having bidirectional neural connections with the lateral septum: the perifornical area of the anterior hypothalamus rich in chondroitin sulfate proteoglycans.2015

    • Author(s)
      Horii-Hayashi N, Sasagawa T, Hashimoto T, Kaneko T, Takeuchi K, Nishi M.
    • Journal Title

      Eur J Neurosci.

      Volume: 42(6) Issue: 6 Pages: 2322-2234

    • DOI

      10.1111/ejn.13024

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Developmental and structural variety of the chondroitin sulfate proteoglycans-contained extracellular matrix in the mouse brain2015

    • Author(s)
      Horii-Hayashi N, Sasagawa T, Matsunaga W, Nishi M
    • Journal Title

      Neural plasticity.

      Volume: 2015 Pages: 256389-256389

    • DOI

      10.1155/2015/256389

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of early life adverse experieneces on brain: implications from maternal separation models in rodents2014

    • Author(s)
      Nishi M, Horii-Hayashi N, Sasagawa T
    • Journal Title

      Frontiers in Neuroscience

      Volume: 8 Pages: 166-166

    • DOI

      10.3389/fnins.2014.00166

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Imaging of corticosteroid receptors in live cells.2014

    • Author(s)
      Nishi M
    • Journal Title

      Methods Mol Biol

      Volume: 1204 Pages: 205-218

    • DOI

      10.1007/978-1-4939-1346-6_18

    • ISBN
      9781493913459, 9781493913466
    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Distribution of corticosteroid receptors in mature oligodendrocytes and oligodendrocyte progenitors of the adult mouse brain.2014

    • Author(s)
      Matsusue M, Horii-Hayashi N, Kirita T, Nishi M
    • Journal Title

      J Histochem Cytochem

      Volume: 62 Issue: 3 Pages: 211-226

    • DOI

      10.1369/0022155413517700

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differences in elements between intact and disrupted human ligamenta capitum femorum.2014

    • Author(s)
      Shinohara Y, Kumai T, Higashiyama I, Tanaka Y, Takakura Y, Nishi M, Azuma C, Minami T, Tohno Y.
    • Journal Title

      Biol Trace Elem Res.

      Volume: 160 Issue: 2 Pages: 161-168

    • DOI

      10.1007/s12011-014-0036-2

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] マウス脳に新たに発見・同定した視床下部領域について.2016

    • Author(s)
      堀井謹子、笹川誉世、橋本隆、西真弓
    • Organizer
      第121回日本解剖学界総会・全国学術集会
    • Place of Presentation
      福島
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] サル輪状軟骨の元素蓄積の特徴.2016

    • Author(s)
      東超、大石高生、東野義之、東野勢津子、南武志、西真弓
    • Organizer
      第121回日本解剖学界総会・全国学術集会
    • Place of Presentation
      福島
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Effects of early life stress on the brain.2016

    • Author(s)
      Mayumi Nishi, Takayo Sasagawa, Noriko Horii-Hayashi.
    • Organizer
      第89回日本薬理学会年会 シンポジウム
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 幼少期ストレスによる嗜好性食餌に対する摂食・欲求行動への影響について.2015

    • Author(s)
      笹川誉世、堀井謹子、奥田哲教、西真弓
    • Organizer
      第56回日本組織細胞化学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-10-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] 幼少期ストレスによる嗜好性食餌に対する摂食・欲求行動への影響について.2015

    • Author(s)
      笹川誉世、堀井謹子、奥田哲教、西真弓
    • Organizer
      第42回日本神経内分泌学会・第23回日本行動神経内分泌研究会合同学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Effects of early life adverse experiences on the brain.2015

    • Author(s)
      Mayumi Nishi, Noriko Horii-Hayashi, Takayo Sasagawa
    • Organizer
      第42回日本神経内分泌学会企画国際シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] A new hypothalamic area enriched with perineuronal nets having bidirectional connections between the lateral septum.2015

    • Author(s)
      Mayumi Nishi, Noriko Horii-Hayashi, Takayo Sasagawa
    • Organizer
      Parvo-and Magnocellular Symposium in Sendai―Creating a New Stream of Neuroendocrinology
    • Place of Presentation
      仙台
    • Year and Date
      2015-09-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] A newly identified hypothalamic area enriched with perineuronal net-positive neurons.2015

    • Author(s)
      Noriko Horii, Takayo Sasagawa, Takashi Hashimoto, Mayumi Nishi
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Effects of early life stress on feeding behavior for palatable foods.2015

    • Author(s)
      Takayo Sasagawa, Noriko Horii, Mayumi Nishi
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Effects of early life adverse experiences on the brain: Implications from maternal separation models in rodents.2015

    • Author(s)
      Mayumi Nishi, Noriko Horii-Hayashi, Takayo Sasagawa
    • Organizer
      第120回日本解剖学会総会・全国学術集会・第92回日本生理学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] A Newly-identified hypothalamic area enriched with perineuronal nets.2015

    • Author(s)
      Noriko Horii-Hayashi, Takayo Sasagawa, Takashi Hashimoto, Mayumi Nishi
    • Organizer
      第120回日本解剖学会総会・全国学術集会・第92回日本生理学会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Axon regeneration and motor function improvement with scaffold-free BMSC sheet transplantation to completely transected spinal cord rat.2015

    • Author(s)
      Akinori Okuda, Noriko Horii, Takayo Sasagawa, Yasuhito Tanaka, Mayumi Nishi
    • Organizer
      第120回日本解剖学会総会・全国学術集会・第92回日本生理学会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 視床下部領域に新たに見いだしたペリニューロナルネット陽性神経細胞を有する領域2014

    • Author(s)
      西真弓
    • Organizer
      埼玉大学・理学部・大学院セミナー
    • Place of Presentation
      埼玉
    • Year and Date
      2014-11-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 幼少期ストレスが脳の可塑性におよぼす影響:母子分離モデルを用いた解析2014

    • Author(s)
      西真弓
    • Organizer
      つくばブレインサイエンスセミナー
    • Place of Presentation
      筑波
    • Year and Date
      2014-11-11
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 長残光蛍光体を用いた無励起光新規イメージング技術の開発2014

    • Author(s)
      清水隆昌、赤羽学、多喜正泰、田部勢津久、石田昭人、城戸顕、田中康仁、西真弓
    • Organizer
      第46回日本臨床分子形態学会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 長残光蛍光体ナノ粒子を用いた無励起光バイオイメージング2014

    • Author(s)
      清水隆昌、赤羽学、多喜正泰、田部勢津久、石田昭人、城戸顕、田中康仁、西真弓
    • Organizer
      第55回日本組織細胞化学会総会・学術集会
    • Place of Presentation
      松本
    • Year and Date
      2014-09-27 – 2014-09-28
    • Related Report
      2014 Research-status Report
  • [Presentation] Effects of early life stress on palatable feeding behavior.2014

    • Author(s)
      Takayo Sasagawa, Noriko Horii-Yayashi, Takashi Hashimoto, Mayumi Nishi
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] The effect of maternal separation in the nucleus of accumbens and the bed nucleus of stria terminalis of the adult mouse: gene profiles after early life stress.2014

    • Author(s)
      Takashi Hashimoto, Noriko Horii, Takayo Sasagawa, Mayumi Nishi
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 長残光蛍光体ナノ粒子を用いた無励起光バイオイメージング2014

    • Author(s)
      西真弓
    • Organizer
      イノベーション・ジャパン2014「知の融合 ~広がる未来~」
    • Place of Presentation
      東京
    • Year and Date
      2014-09-11 – 2014-09-12
    • Related Report
      2014 Research-status Report
  • [Presentation] A new hypothalamic area enriched with perineuronal nets having bidirectional connections between the lateral septum abs#83.2014

    • Author(s)
      Mayumi Nishi
    • Organizer
      8th International Congress of Neuroendocrinology 2014
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2014-08-17 – 2014-08-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 幼少期のストレスが脳の可塑性におよぼす影響について:母子分離モデルによる解析2014

    • Author(s)
      西真弓
    • Organizer
      長崎大学大学院セミナー
    • Place of Presentation
      長崎
    • Year and Date
      2014-07-02
    • Related Report
      2014 Research-status Report
  • [Presentation] Dynamics of corticosteroid hormone receptors: implications from live cell imaging.2014

    • Author(s)
      Mayumi Nishi
    • Organizer
      The 7th International Aldosterone Forum in Japan
    • Place of Presentation
      Yokohama
    • Year and Date
      2014-05-31
    • Related Report
      2014 Research-status Report
  • [Book] The Big Picture Gross Anatomy2014

    • Author(s)
      西真弓
    • Total Pages
      484
    • Publisher
      McGraw Hill books
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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