| Project/Area Number |
26560236
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
田中 進 高崎健康福祉大学, 健康福祉学部, 教授 (70348142)
槇 靖幸 群馬大学, 大学院理工学府, 助教 (50400776)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 足場 / 細胞接着 / 細胞増殖 / ゲル / 紫外線 / 細胞培養 |
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| Outline of Final Research Achievements |
Human fibroblast cells WI-38 can be cultured on a UV-irradiated gelatin microcapsule scaffold, whereas cancered cells WI-38-VA-13 can not be grown on the microcapsules. In this study we tried to determine the preparation condition of such cell-specific scaffolds and develop a new technology using the scaffold for medical applications. We found that (1) the cell-specific property is controlled by dose of UV irradiation, (2) the cell-specificity depends on the differentiation degree of stomach cancer cells, and the cell adhesion and proliferation can be modified by the combination of scaffold and anti-cancer agent.
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