Effects of atelocollagen gel combined with cell sheets on articular cartilage repair
Project/Area Number |
26560246
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Biomedical engineering/Biomaterial science and engineering
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Research Institution | Tokai University |
Principal Investigator |
SATO Masato 東海大学, 医学部, 教授 (10056335)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | 関節軟骨修復再生 / アテロコラーゲンゲル / 細胞シート / 軟骨修復再生 / TGF-β1 |
Outline of Final Research Achievements |
Atelocollagen gel has the qualities of strength and transparency as well as permeability that make it suitable as carriers of humoral factors important for articular cartilage repair. Acellular sheets were fabricated from atelocollagen gel and evaluated. They attached well to and improved the handling of chondrocyte sheets. To evaluate articular cartilage repair, acellular sheets were transplanted to a rabbit osteochondral defect model and proved effective to some extent and safe without any indication of adverse events such as infection or inflammation. In a further study, the incorporation and release of TGF-β1 from the acellular sheets further improved the treatment effect. Our results suggest that the regeneration of articular cartilage may be induced by the activation of endogenous repair mechanisms.
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Report
(4 results)
Research Products
(5 results)
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[Journal Article] Effects of a cell-free method using collagen vitrigel incorporating TGF-β1 on articular cartilage repair in a rabbit osteochondral defect model.2017
Author(s)
Maruki H, Sato M, Takezawa T, Tani Y, Yokoyama M, Takahashi T, Toyoda E, Okada E, Aoki S, Mochida J, Kato Y.
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Journal Title
J Biomed Mater Res B Appl Biomater
Volume: 印刷中
Issue: 8
Pages: 2592-2602
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] TGF‐β1含浸コラーゲンビトリゲルを用いた関節軟骨損傷の治療効果の検討2015
Author(s)
丸木秀行, 佐藤正人, 竹澤俊明, 谷良樹, 横山宗昴, 小林美由希, 小久保舞美, 河毛知子, 岡田恵里, 持田讓治, 加藤義治
Organizer
第30回日本整形外科学会基礎学術集会
Place of Presentation
富山国際会議場、ANAクラウンプラザホテル富山、富山市民プラザ、グランドプラザ(富山県富山市)
Year and Date
2015-10-22
Related Report
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