| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Outline of Final Research Achievements |
Atelocollagen gel has the qualities of strength and transparency as well as permeability that make it suitable as carriers of humoral factors important for articular cartilage repair. Acellular sheets were fabricated from atelocollagen gel and evaluated. They attached well to and improved the handling of chondrocyte sheets. To evaluate articular cartilage repair, acellular sheets were transplanted to a rabbit osteochondral defect model and proved effective to some extent and safe without any indication of adverse events such as infection or inflammation. In a further study, the incorporation and release of TGF-β1 from the acellular sheets further improved the treatment effect. Our results suggest that the regeneration of articular cartilage may be induced by the activation of endogenous repair mechanisms.
|
