| Project/Area Number |
26560249
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | National Defense Medical College |
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Principal Investigator |
Ishihara Masayuki 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, その他部局等, 教授 (10508500)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAHIRA Yasushi 防衛医科大学校, その他の部局等, 教授 (40265781)
HATTORI Hidemi 防衛医科大学校, その他の部局等, 助教 (80508549)
NAKAMURA Shingo 防衛医科大学校, その他の部局等, 講師 (00505323)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ナノバイオ材料 / 抗微生物材料 / 酸化ストレス |
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| Outline of Final Research Achievements |
Size-controlled spherical silver nanoparticles (Ag NPs; diameter: about 5 ± 2 nm) can be simply prepared by autoclaving mixtures of silver-containing glass powder with glucose. The Ag NPs were homogenously dispersed and stably adsorbed onto the surface of chitin powders and CNFS with nanoscale fiber-like surface structure and chitosan powders with nanoscale porous surface structures. The antimicrobial activity of chitin/Ag NPs and CNFS/Ag NPs composites increased when the amounts of Ag NPs adsorbed to the chitin powder and CNSF increased. Furthermore, the proposed mechanism by which Ag NPs lead to cytotoxicity has been considered to partially be through the induction of reactive oxygen species (ROS) as an oxidative stress.
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