Quantitative imaging of the target fluorescent substance by fluorescence multispectral endoscope
Project/Area Number |
26560267
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Medical systems
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Research Institution | National Defense Medical College |
Principal Investigator |
Morimoto Yuji 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 准教授 (10449069)
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Co-Investigator(Kenkyū-buntansha) |
IWAYA Keiichi 公益財団法人佐々木研究所, その他の部局等, 研究員 (50312012)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 画像診断システム / 内視鏡 / 蛍光 |
Outline of Final Research Achievements |
To achieve a quantitative imaging of labeled fluorescent substances, a novel endoscopic system equipped with a fluorescence multispectral imaging system coupled to the spectral unmixing function was established. This system can visualize a fluorescence spectral unmixing image with a rate of 1 f/s. We verified the detectability of the newly developed endoscopic system for pathological lesions. Using a mouse atherosclerosis model or a rat esophageal tumor model, we succeeded to clearly visualize an atherosclerotic plaques or esophageal tumors in real time.
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Report
(3 results)
Research Products
(7 results)
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[Journal Article] Design Strategy for Small Molecule-based Targeted MRI Contrast Agents: Application for Detection of Atherosclerotic Plaques2014
Author(s)
Iwaki, S.; Hokamura, K.; Ogawa, M.; Takehara, Y.; Muramatsu, Y.; Yamane, T.; Hirabayashi, K.; Morimoto, Y.; Hagisawa, K.; Nakahara, K.; Mineno, T.; Terai, T.; Komatsu, T.; Ueno, T.; Tamura, K,; Adachi, Y.; Hirata, Y.; Arita, M.; Arai, H.; Umemura, K.; Nagano T. and Hanaoka K.
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Journal Title
Organic & Biomolecular Chemistry
Volume: 12
Issue: 43
Pages: 8611-8618
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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