| Project/Area Number |
26560366
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Sports science
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITAURA Yasuyuki 名古屋大学, 大学院生命農学研究科, 助教 (90442954)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 分岐鎖アミノ酸 / 分岐鎖α-ケト酸脱水素酵素キナーゼ / 運動トレーニング / 持久力 / マウス / コンディショナルノックアウト / 筋肉 / コンディショナルノックアウトノックアウト / 持久走 |
|---|
| Outline of Final Research Achievements |
We produced muscle-specific branched-chain α-ketoacid dehydrogenase kinase (BDK)-deficient mice, in which the catabolism of branched-chain amino acids (BCAAs) were promoted in a muscle-specific manner. The mice showed decreased adaptability to exercise training compared to control mice. It was suggested that decreased muscle glycogen content, low activities of mitochondrial enzymes, derivatization of BCAA catabolites, and suppression of glycolysis were involved in the mechanisms.
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