| Project/Area Number |
26560370
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Sports science
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| Research Institution | Waseda University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Sako Hiroaki 早稲田大学, 大学院スポーツ科学研究科, 博士課程
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 運動 / 翻訳動態 / Ribosome profiling / 次世代シーケンサー / マウス / 骨格筋 / 遺伝子 / タンパク質 / リボソームプロファイリング / 翻訳 / 遺伝子発現 / マクロファージ / 炎症 / 網羅的解析 / 翻訳調節 / フレームシフト / 翻訳速度 |
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| Outline of Final Research Achievements |
Not only the dynamic changes in transcription, but also those in translation in relation with mechanisms of action have great impacts on biological systems. In addition, recently, technological advancement due to ribosome profiling using the next-generation sequencer ennables us to analyze translational dynamics globally and with a high degree of accuracy for one nucreotide unit. Using this technology, we investigated the effect of exercise on translational dynamics with a genome-wide, and revealed new mechanisms of action together with nobel cis-elements in response to acute pro- and anti-inflammatory responses.
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