• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The effect of skeletal muscle adaptation on the development of aortic atherosclerosis

Research Project

Project/Area Number 26560400
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Applied health science
Research InstitutionUniversity of Shizuoka

Principal Investigator

Miura Shinji  静岡県立大学, 食品栄養科学部, 教授 (10342932)

Co-Investigator(Kenkyū-buntansha) MORITA Akihito  静岡県立大学, 食品栄養科学部, 助教 (40239653)
IKEDA Masahiko  常葉大学, 環境学研究科, 教授 (20232176)
Co-Investigator(Renkei-kenkyūsha) GODA Toshinao  静岡県立大学, 食品栄養科学部, 教授 (70195923)
KAMEI Yasutomi  京都府立大学, 生命環境科学研究科, 教授 (70300829)
Research Collaborator SHIMBA Yuki  
TOGAWA Hanako  
SENOO Nanami  
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords動脈硬化 / 筋線維の遅筋化 / 転写調節因子 / ApoE KOマウス / PGC-1α / FOXO1 / 健康・スポーツ科学 / 応用健康科学 / 生活習慣病
Outline of Final Research Achievements

To examine whether the overexpression of PGC-1alpha in skeletal muscle could prevent the development of aortic atherosclerosis, we created the ApoE knockout mice overexpressing PGC-1alpha in the skeletal muscle. ApoE knockout mice without overexpression of PGC-1alpha were used as control. Hearts and fasting plasma samples were collected at the age of 16-20 weeks. The HE stained sections of the proximal aorta were evaluated for the cross-sectional area of lesions from the aortic root. Lipoprotein profiles were also measured. The skeletal muscle overexpression of PGC-1alpha could decrease by 43% in cross-sectional area of lesion as compared to control ApoE knockout mice. Plasma total cholesterol and VLDL-cholesterol levels were also decreased in ApoE knockout mice overexpressing PGC-1alpha.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 2 results)

  • [Journal Article] Glycerol 3-phosphate dehydrogenase 1 deficiency enhances exercise capacity due to increased lipid oxidation during strenuous exercise.2015

    • Author(s)
      Sato, T., Morita, A., Mori, N., and Miura, S.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 457 Issue: 4 Pages: 653-658

    • DOI

      10.1016/j.bbrc.2015.01.043

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Mechanisms of exercise- and training-induced fatty acid oxidation in skeletal muscle2014

    • Author(s)
      Miura, S., Tadaishi, M., Kamei, Y., and Ezaki, O.
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 3 Issue: 1 Pages: 43-53

    • DOI

      10.7600/jpfsm.3.43

    • NAID

      130003397904

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi