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Studies on novel measurement methods of brain functions with optical super-sensitive atomic magnetometers

Research Project

Project/Area Number 26560466
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Brain biometrics
Research InstitutionKyoto University

Principal Investigator

Kobayashi Tetsuo  京都大学, 工学(系)研究科(研究院), 教授 (40175336)

Co-Investigator(Renkei-kenkyūsha) OIDA TAKENORI  京都大学, 大学院工学研究科, 助教 (70447910)
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords光ポンピング / 原子磁気センサ / 神経磁場 / MEG / fMRI / 脳神経磁場
Outline of Final Research Achievements

The goal of this study was to develop super-sensitive optically pumped atomic magnetometers to measure magnetoencephalograms (MEGs) and to propose a new principle of functional MRI as well. First, we could successfully increase the sensitivity of optically pumped atomic magnetometers (OPAMs) with our newly developed optical gradiometers, in which the differential output of two distinct measurement areas inside a glass cell was obtained directly via the magneto-optical rotation of one probe beam. Next, we fabricated novel module type OPAMs and could measure visually evoked magnetic fields with them. Furthermore, we carried out theoretical and experimental studies on a MRI with spin-lock sequence, which has potential to detect neural magnetic field dependent (NMFD) changes in MR signal intensities and could measure alternating very small magnetic fields in a biological phantom with high (7T) and low (0.3T) MRIs. The results were validated by numerical calculations based on the Bloch.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (45 results)

All 2016 2015 2014 Other

All Journal Article (19 results) (of which Peer Reviewed: 11 results,  Acknowledgement Compliant: 14 results,  Open Access: 1 results) Presentation (23 results) (of which Int'l Joint Research: 5 results,  Invited: 8 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Differential measurement using equalized response of optically pumped atomic magnetometers2016

    • Author(s)
      Sunao Ichihara, Natsuhiko Mizutani, Yosuke Ito and Tetsuo Kobayashi
    • Journal Title

      IEEE Trans. on Magnetics

      Volume: 52 Issue: 8 Pages: 1-9

    • DOI

      10.1109/tmag.2016.2547364

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Towards Biomagnetic Field Measurements2016

    • Author(s)
      小林哲生
    • Journal Title

      The Journal of The Institute of Electrical Engineers of Japan

      Volume: 136 Issue: 1 Pages: 8-9

    • DOI

      10.1541/ieejjournal.136.8

    • NAID

      130005114981

    • ISSN
      1340-5551, 1881-4190
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optically pumped Atomic Magnetometer2016

    • Author(s)
      小林哲生
    • Journal Title

      The Journal of The Institute of Electrical Engineers of Japan

      Volume: 136 Issue: 1 Pages: 26-29

    • DOI

      10.1541/ieejjournal.136.26

    • NAID

      130005114968

    • ISSN
      1340-5551, 1881-4190
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 超高感度な光学的磁気センサを用いた新たなニューロイメージングに向けて2015

    • Author(s)
      小林哲生
    • Journal Title

      Vision

      Volume: 27 Pages: 73-79

    • Related Report
      2015 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] モジュール型4ch光ポンピング原子磁気センサによる視覚誘発脳磁界計測2015

    • Author(s)
      夏川浩明、山本哲也、小林哲生
    • Journal Title

      電子情報通信学会技術研究報告

      Volume: 115 Pages: 29-32

    • Related Report
      2015 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] 生体磁気計測に向けた光ポンピングハイブリッド原子磁気センサのポンプ光変調による複数点同時計測2015

    • Author(s)
      馬見新友樹,伊藤陽介,小林哲生
    • Journal Title

      電気学会マグネティックス研究会資料

      Volume: MAG15-96 Pages: 17-22

    • Related Report
      2015 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] 光ポンピングK-Rbハイブリッド原子磁気センサにおける差動計測と心磁図への応用2015

    • Author(s)
      小島史崇,伊藤陽介,小林哲生
    • Journal Title

      電気学会マグネティックス研究会資料

      Volume: MAG15-97 Pages: 23-28

    • Related Report
      2015 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] MRIを用いた機能的結合計測に向けた脳神経磁場イメージングに関する検討2015

    • Author(s)
      伊藤陽介,上野雅仁、小林哲生
    • Journal Title

      日本生体磁気学会誌

      Volume: 28 Pages: 142-143

    • Related Report
      2015 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] 光ポンピングK-Rbハイブリッド原子磁気センサを用いた差動計測の基礎検討2015

    • Author(s)
      小島史崇,伊藤陽介,小林哲生
    • Journal Title

      日本生体磁気学会誌

      Volume: 28 Pages: 160-161

    • Related Report
      2015 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] 光ポンピングハイブリッド原子磁気センサを用いたポンプ光強度変調による多点同時計測2015

    • Author(s)
      馬見新友樹,伊藤陽介,小林哲生
    • Journal Title

      日本生体磁気学会誌

      Volume: 28 Pages: 162-163

    • Related Report
      2015 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] 光ポンピング原子磁気センサにおける差動測定の適用範囲の検討2015

    • Author(s)
      市原 直,鎌田啓吾,伊藤陽介,水谷夏彦,小林哲生
    • Journal Title

      日本生体磁気学会誌

      Volume: 28 Pages: 56-57

    • Related Report
      2015 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Human magnetoencephalogram measurements using newly developed compact module of high-sensitivity atomic magnetometer2015

    • Author(s)
      Keigo Kamada, Daichi Sato, Yosuke Ito, Hiroaki Natsukawa, Kazuhisa Okano, Natsuhiko Mizutani, Tetsuo Kobayashi
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: Vol.54, No.2 Issue: 2 Pages: 026601-026601

    • DOI

      10.7567/jjap.54.026601

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Noise reduction and signal-to-noise ratio improvement of atomic magnetometers with optical gradiometer configurations2015

    • Author(s)
      Keigo Kamada, Yosuke Ito, Sunao Ichihara, Natsuhiko Mizutani, Tetsuo Kobayashi
    • Journal Title

      Optics Express

      Volume: Vol.23, Iss.5 Issue: 5 Pages: 6976-6987

    • DOI

      10.1364/oe.23.006976

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A plateau in the sensitivity of a compact optically pumped atomic magnetometer module2014

    • Author(s)
      Natsuhiko Mizutani, Kazuhisa Okano, Kazuhiro Ban, Sunao Ichihara, Akira Terao and Tetsuo Kobayashi
    • Journal Title

      AIP advances

      Volume: 4 Issue: 5

    • DOI

      10.1063/1.4880498

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Measurements of magnetic field distributions with an optically pumped K-Rb hybrid atomic Magnetometer2014

    • Author(s)
      Yousuke Ito, Hiroyuki Ohnishi, Keigo Kamada, Tetsuo Kobayashi
    • Journal Title

      IEEE Transactions on Magnetics

      Volume: 50 Issue: 11 Pages: 4006903-4006903

    • DOI

      10.1109/tmag.2014.2329856

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 脳神経磁場イメージングの新たな試み(解説論文)2014

    • Author(s)
      小林哲生
    • Journal Title

      シミュレーション

      Volume: 33 Pages: 18-23

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 原子磁気センサモジュールによる事象関連脱同期及び事象関連脳磁界の計測2014

    • Author(s)
      鎌田啓吾、伊藤陽介,夏川浩明、岡野一久,水谷夏彦,小林哲生
    • Journal Title

      電子情報通信学会技術研究報告

      Volume: 114(258) Pages: 31-36

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] MRIを用いた脳神経磁場イメージング:機能的結合計測に向けたシミュレーションとファントム実験2014

    • Author(s)
      上野雅仁、伊藤陽介,小林哲生
    • Journal Title

      電子情報通信学会技術研究報告

      Volume: 114(361) Pages: 27-32

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 光ポンピングK-Rbハイブリッド原子磁気センサにおけるアルカリ金属原子の密度比に関する検討2014

    • Author(s)
      佐藤大地,鎌田啓吾,伊藤陽介,小林哲生
    • Journal Title

      電子情報通信学会技術研究報告

      Volume: 114(361) Pages: 33-38

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 脳磁図計測に向けた光ポンピングハイブリッド原子磁気センサのグラジオメータ構成によるノイズ低減効果の検討2016

    • Author(s)
      小島史嵩, 伊藤陽介, 小林哲生
    • Organizer
      第18回日本ヒト脳機能マッピング学会
    • Place of Presentation
      京都
    • Year and Date
      2016-03-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 光ポンピング原子磁気センサによるMEG計測に向けた変調したポンプ光を用いた多チャンネル化の検討2016

    • Author(s)
      馬見新友輝、伊藤陽介、小林哲生
    • Organizer
      第18回日本ヒト脳機能マッピング学会
    • Place of Presentation
      京都
    • Year and Date
      2016-03-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] マルチチャネルモジュール型光ポンピング原子磁気センサを用いた視覚誘発脳磁界計測2016

    • Author(s)
      小野雅史, 夏川浩明, 山本哲也, 岡野一久, 寺尾 亮, 水谷夏彦, 小林哲生
    • Organizer
      第18回日本ヒト脳機能マッピング学会
    • Place of Presentation
      京都
    • Year and Date
      2016-03-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 光ポンピング原子磁気センサによる視覚誘発応答計測時のノイズ低減:多チャネル脳波計の併用2016

    • Author(s)
      山本哲也、夏川浩明、小林哲生
    • Organizer
      日本視覚学会2016年冬季大会
    • Place of Presentation
      東京
    • Year and Date
      2016-01-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] MRIを用いた脳神経磁場イメージング:機能的結合計測に向けたシミュレーションとファントム実験2015

    • Author(s)
      上野雅仁、伊藤陽介,小林哲生
    • Organizer
      第3回宮古島神経科学カンファレンス
    • Place of Presentation
      宮古島
    • Year and Date
      2015-11-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] Towards optical biomagnetic imaging systems2015

    • Author(s)
      Tetsuo Kobayashi
    • Organizer
      The 3rd Workshop on Optically Pumped Magnetometry
    • Place of Presentation
      Helsinki, Finland
    • Year and Date
      2015-10-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Simultaneous measurements of magnetic field distributions with an optically pumped K-Rb atomic magnetometer toward biomagnetic field measurements2015

    • Author(s)
      Yosuke Ito, Yuki Mamishin, Daisuke Sato, Keigo Kamada and Tetsuo Kobayashi
    • Organizer
      International Conference on Basic and Clinical Multimodal Imaging(BaCI)2015
    • Place of Presentation
      Utrecht, The Netherlands
    • Year and Date
      2015-09-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] モジュール型光ポンピング原子磁気センサによる視覚誘発脳磁界計測:SQUID全頭型MEG計測との比較2015

    • Author(s)
      夏川浩明、鎌田啓吾、山本哲也、小林哲生
    • Organizer
      第17回日本ヒト脳機能マッピング学会
    • Place of Presentation
      大阪
    • Year and Date
      2015-07-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] モジュール型光ポンピング原子磁気センサによる視覚誘発脳磁界計測:多チャネル脳波計との同時計測2015

    • Author(s)
      山本哲也、夏川浩明、鎌田啓吾、小林哲生
    • Organizer
      第17回日本ヒト脳機能マッピング学会
    • Place of Presentation
      大阪
    • Year and Date
      2015-07-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] Optically pumped atomic magnetometer: Advancements and perspectives for biomagnetic imaging2015

    • Author(s)
      Tetsuo Kobayashi
    • Organizer
      Complex Medical Engineering(CME)2015
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2015-06-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Direct detection of oscillating magnetic fields with MRI toward functional connectivity measurements2015

    • Author(s)
      Tetsuo Kobayashi, Masahito Ueno and Yosuke Ito
    • Organizer
      Human Brain Mapping(HBM)2015
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      2015-06-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Measurements of human visual evoked fields using a compact atomic magnetometer module2015

    • Author(s)
      Hiroaki Natsukawa, Keigo Kamada, Tetsuya Yamamoto and Tetsuo Kobayashi
    • Organizer
      Human Brain Mapping(HBM)2015
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      2015-06-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 光学的生体磁気イメージングシステムの開発と展望2015

    • Author(s)
      小林哲生
    • Organizer
      第30回日本生体磁気学会大会
    • Place of Presentation
      旭川
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 光ポンピング原子磁気センサの基礎と脳磁図・MR信号計測2015

    • Author(s)
      小林哲生
    • Organizer
      東北大学スピニクス研究会
    • Place of Presentation
      仙台
    • Year and Date
      2015-03-19
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 超高感度な光学的磁気センサを用いた新たなニューロイメーメジングに向けて2015

    • Author(s)
      小林哲生
    • Organizer
      日本視覚学会2015年冬季大会
    • Place of Presentation
      東京
    • Year and Date
      2015-01-22 – 2015-01-23
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 高感度光ポンピング原子磁気センサモジュールによる視覚誘発応答計測2015

    • Author(s)
      夏川浩明、鎌田啓吾、山本哲也、小林哲生
    • Organizer
      日本視覚学会2015年冬季大会
    • Place of Presentation
      東京
    • Year and Date
      2015-01-22 – 2015-01-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 光ポンピング原子磁気センサと多チャネル脳波計による視覚誘発応答の同時計測2015

    • Author(s)
      山本哲也、夏川浩明、伊藤達哉,鎌田啓吾、小林哲生
    • Organizer
      日本視覚学会2015年冬季大会
    • Place of Presentation
      東京
    • Year and Date
      2015-01-22 – 2015-01-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 光学的グラジオメータによる光ポンピング原子磁気センサのノイズ低減2014

    • Author(s)
      鎌田啓吾,伊藤陽介,市原 直,水谷夏彦,小林哲生
    • Organizer
      第75回応用物理学会学秋季術講演会
    • Place of Presentation
      札幌
    • Year and Date
      2014-09-17 – 2014-09-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 光ポンピング原子磁気センサを用いたポンプ光変調による磁場分布計測に向けた検討2014

    • Author(s)
      伊藤陽介,佐藤大地,鎌田啓吾,小林哲生
    • Organizer
      第75回応用物理学会学秋季術講演会
    • Place of Presentation
      札幌
    • Year and Date
      2014-09-17 – 2014-09-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Development of Atomic Magnetometers towards New Biomagnetic Imaging Systems2014

    • Author(s)
      Tetsuo Kobayashi
    • Organizer
      Biomag2014 Satellite Workshop
    • Place of Presentation
      Halifax, Canada
    • Year and Date
      2014-08-24
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 光ポンピング原子磁気センサ:新たなMEGとMRIを目指して2014

    • Author(s)
      小林哲生
    • Organizer
      第53回日本生体医工学会学会大会
    • Place of Presentation
      仙台
    • Year and Date
      2014-06-24 – 2014-06-26
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Atomic magnetometerの開発とそのMEG計測への応用2014

    • Author(s)
      小林哲生
    • Organizer
      第29回日本生体磁気学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-29 – 2014-05-30
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Measurements of magnetic field distribusions with an optically pumped K-Rb hybrid atomic magnetometer2014

    • Author(s)
      Yosuke Ito, Hiroyuki Ohnishi, Keigo Kamada and Tetsuo Kobayashi
    • Organizer
      Intermag 2014
    • Place of Presentation
      Dresden, Germany
    • Year and Date
      2014-05-04 – 2014-05-08
    • Related Report
      2014 Research-status Report
  • [Remarks] 京都大学 大学院工学研究科 電気工学専攻 生体医工学講座 小林研究室 研究発表

    • URL

      http://bfe.kuee.kyoto-u.ac.jp/publications.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 京都大学大学院工学研究科電気工学専攻生体機能工学分野研究発表

    • URL

      http://bfe.kuee.kyoto-u.ac.jp/publications.html

    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] ポンプ光変調による磁場分布計測方法2014

    • Inventor(s)
      小林哲生,伊藤陽介,市原直,水谷夏彦
    • Industrial Property Rights Holder
      小林哲生,伊藤陽介,市原直,水谷夏彦
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-175881
    • Filing Date
      2014-08-29
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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