antimicrobial activity of polyoxometalate clusters
| Project/Area Number |
26600021
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nanomaterials chemistry
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 脂質二重膜 / ポリオキソメタレート / 自己組織化 / 細胞膜 / クラスター / リポソーム |
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| Outline of Final Research Achievements |
We investigated the antimicrobial activity of polyoxometalate by micro- and nanoscopic imaging techniques. Imaging experiments revealed vigorous desorption of the lipid bilayer from solid substrate by the formation of POM-lipid assembly through a supramolecular-type assembly process in which electrostatic and hydrophobic interactions between the POM and lipid determines the efficiency and dynamics of assembly formation and thereby determines lipid desorption. Furthermore, maximum efficiency of lipid desorption was found at the phase transition temperature. This phase dependency was explained by the formation of a “leaky interface” between the gel and fluid domains, in which freedom in the conformational change of lipids during the formation of the POM–lipid assemblies becomes maximal.
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Report
(3 results)
Research Products
(21 results)
