Development of cell cultivation dish based radiation detector in single-crystal CVD diamond membrane

• Project/Area Number: 26600139
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Quantum beam science
• Research Institution: Gunma University
• Principal Investigator: Kada Wataru 群馬大学, 大学院理工学府, 助教 (60589117)
• Co-Investigator(Kenkyū-buntansha): 酒井 真理 群馬大学, 医学(系)研究科(研究院), 助教 (70727338)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: ダイヤモンド / 細胞培養ディシュ / 荷電粒子検出 / 反応性イオンエッチング / イオンビーム微細加工 / アルファ粒子検出 / イオンマイクロビーム / α粒子検出 / 細胞培養ディッシュ

Outline of Final Research Achievements

In this study , charged particle detectors with embedded cell cultivating structure were newly developed with thin film single crystalline diamond. Trench structure for cell cultivation was formed on the surface of the thin-film single crystal diamond (3 mm × 3 mm × 30μm) by reactive ion etching with oxygen plasma . Bio-compatibility of the diamond surface was confirmed by cultivating HSG cells on the device. Then, an electrode was formed on the backside of the diamond film to evaluate its detector response under cell cultivating conditions. Response of the developed charged particle detector was evaluated under radiation exposure of alpha particles from 241Am source and protons from accelerator.

Research Products

• [Int'l Joint Research] Laboratory for Ion Beam Interactions/Experimental Physics Division/Rudjer Boskovic Institute(クロアチア)
• [Presentation] Living-cell Cultivation on a CVD Diamond Dosimeter (2015)
  • Author(s): M. Sakai, W. Kada, M. Pomorski, and O. Hanaizumi
  • Organizer: 2nd International Symposium of Gunma University Medical Innovation (GUMI2015)
  • Place of Presentation: Tojyo Hall, Gunma University,3-39-22 Showa-machi, Maebashi City,Gunma, Japan
  • Year and Date: 2015-12-08
  • Int'l Joint Research
• [Presentation] Current R&D Status on Micro-Dosimetry and Three-Dimensional Dosimetry Technique using Compton Camera for Heavy Ion Radiation Therapy at Gunma University (2015)
  • Author(s): M. Sakai
  • Organizer: The 11th International Workshop on Radiation Effects on Semiconductor Devices for Space Applications (11th RASEDA) & The 7th International Conference on Advanced Micro-Device Engineering (7th AMDE)
  • Place of Presentation: City Performing Arts Center, Kiryu, Gunma, Japan
  • Year and Date: 2015-11-11
  • Int'l Joint Research / Invited
• [Presentation] Living cell cultivation on single-crystal CVD diamond membrane (2015)
  • Author(s): W. Kada, M. Sakai, M. Pomorski, V. Grilj, N. Skukan, Y. Kambayashi, T. Makino, M. Jaksic, S. Onoda, T. Ohshima, T. Kamiya, and O. Hanaizumi
  • Organizer: 9th International Conference of New Diamond and Nano-Carbon (NDNC2015)
  • Place of Presentation: Shizuoka GRANSHIP, Shizuoka, Japan
  • Year and Date: 2015-05-24
  • Int'l Joint Research
• [Presentation] 荷電粒子検出器となる薄膜型単結晶CVDダイヤモンド上での細胞 培養の試み (2015)
  • Author(s): 加田 渉, 酒井 真理, Pomorski Michal, Grilj Veljko , Skukan Natko , 神林 佑哉, 牧野 高紘, Jakšić Milko, 小野田 忍, 大島 武, 神谷 富裕, 花泉 修
  • Organizer: 第62回応用物理学会春季学術講演会
  • Place of Presentation: 東海大学湘南キャンパス,神奈川県平塚市
  • Year and Date: 2015-03-11 – 2015-03-14
• [Presentation] CVD Diamond Dosimeter Dish for Living-cell Cultivation (2014)
  • Author(s): Makoto Sakai, Wataru Kada, Michal Pomorski and Osamu Hanaizumi
  • Organizer: 1st International Symposium of Gunma University Medical Innovation and Sixth International Conference on Advanced Micro-Device Engineering
  • Place of Presentation: Kiryu City Performing Arts Center, Kiryu,Gunma (Japan)
  • Year and Date: 2014-12-05
• [Presentation] Development of Thin CVD Diamond Detector for Heavy Ion Measurement (2014)
  • Author(s): Wataru Kada, Yuya Kambayashi, Michal Pomorski, Takahiro Makino, Shinobu Onoda, Veljko Grilj, Natko Skukan, Milko Jakšić, Takeshi Ohshima, Tomihiro Kamiya, and Osamu Hanaizumi
  • Organizer: 1st International Symposium of Gunma University Medical Innovation and Sixth International Conference on Advanced Micro-Device Engineering
  • Place of Presentation: Kiryu City Performing Arts Center, Kiryu,Gunma (Japan)
  • Year and Date: 2014-12-05