A numerical study of functional dyspepsia

• Project/Area Number: 26600151
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Computational science
• Research Institution: Tohoku University
• Principal Investigator: Imai Yohsuke 東北大学, 工学(系)研究科(研究院), 特任准教授 (60431524)
• Research Collaborator: MIYAGAWA Taimei 東北大学, 大学院医工学研究科, 博士後期課程学生
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 胃 / 食物流動 / 数値流体力学 / 消化器系 / バイオメカニクス / 撹拌 / 計算力学 / 蠕動運動 / 数値シミュレーション / 消化器 / 計算バイオメカニクス

Outline of Final Research Achievements

To understand the relationship between the peristaltic contraction and the flow in the stomach, we have developed a numerical model of gastric flow. This model is based on a multi-phase flow modeling, an anatomically realistic geometry of the stomach, and a parametric model of peristaltic contractions. Antral recirculation is generated in the stomach. Our result shows that when peristaltic wave velocity increases, the strength of antral recirculation increases, resulting in enhancement of gastric mixing. We also show that mixing strength per one contraction becomes lower when the initiation period of peristaltic contractions is shorter.

Research Products

• [Int'l Joint Research] University of Auckland(New Zealand)
• [Int'l Joint Research] National University of Singapore(Singapore)
• [Presentation] Clarification of Relationship between Gastric Mixing and Movement of Wall (2015)
  • Author(s): T. Miyagawa, Y. Imai, S. Ishida, T. Yamaguchi, T. Ishikawa
  • Organizer: The 8th Asian-Pacific Conference on Biomechanics
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2015-09-17
  • Int'l Joint Research
• [Presentation] Modeling of flow in the stomach (2014)
  • Author(s): Y. Imai, I. Kobayashi, T. Miyagawa, S. Ishida, T. Ishikawa, T. Yamaguchi
  • Organizer: 4th Japan-Switzerland Workshop on Biomechanics
  • Place of Presentation: Shima Kanko Hotel, Mie, Japan
  • Year and Date: 2014-09-02
• [Presentation] A numerical method for simulating gastric flow (2014)
  • Author(s): T. Miyagawa, Y. Imai, T. Yamaguchi, T. Ishikawa
  • Organizer: 11th World Congress on Computational Mechanics
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-07-25