| Project/Area Number |
26620131
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bio-related chemistry
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| Research Institution | Japan Advanced Institute of Science and Technology |
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Principal Investigator |
FUJIMOTO KENZO 北陸先端科学技術大学院大学, マテリアルサイエンス研究科, 教授 (90293894)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 光クロスリンク / DNA操作 / DNA鎖交換 / 光架橋 / DNA鎖置換反応 |
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| Outline of Final Research Achievements |
The specificity of the A-T and G-C hydrogen bonded Watson-Crick interaction is an emerging scientific discipline that seeks to engineer nanoscale system created out of DNA strand. Based on this DNA specificity, various nanoscale DNA device and DNA structure have been reported. Attempts to design and implement chemical reaction circuits to serve as computational components in DNA computing. However, this approach is not always appropriate, given the physical properties of the actual chemical reactions. In order to introduce intelligence in molecular robots, it is important to explore various chemical reactions that might be more suitable for DNA computing. An oligodeoxynucleotide containing CNVK can photo-cross-link to a pyrimidine base in complementary DNA or RNA molecules within a few seconds of photoirradiation. In this study, we developped construction of intelligence toward DNA computing based on photochemical DNA manipulation.
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