Creation of molecular delivery system using stimuli-responsive DNA nanostructures
| Project/Area Number |
26620133
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Bio-related chemistry
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
Endo Masayuki 京都大学, 物質―細胞統合システム拠点, 准教授 (70335389)
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | DNA / ナノ構造体 / DNAオリガミ / 光機能性 / 原子間力顕微鏡 / デリバリーシステム / 細胞機能制御 / DNAナノテクノロジー / ドラッグデリバリー / ＤＮＡオリガミ / デリバリー |
|---|
| Outline of Final Research Achievements |
For creating the basic technology to apply the functional DNA nano-sized structure to the cellular regulation, the novel DNA molecule system was developed and investigated. In this study, functional DNA nanostructures were created, and the opening and closing of the structure was performed by photoirradiation. Using these nanostructures, we have developed a new molecular system for controlling the inclusion and release of gold particles and enzyme activity. These photoresponsive DNA nanostructures created here can be used for delivery of the biomolecules into cells.
|
Report
(3 results)
Research Products
(54 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Optimal Arrangement of Four Short DNA Strands for Delivery of Immunostimulatory Nucleic Acids to Immune Cells2015
Author(s)
Shozo Ohtsuki, Noriyuki Matsuzaki, Kohta Mohri, Masayuki Endo, Tomoko Emura, Kumi Hidaka, Hiroshi Sugiyama, Yuki Takahashi, Kenichi Ishiyama, Norimitsu Kadowaki, Yoshinobu Takakura, Makiya Nishikawa.
-
Journal Title
Nucleic Acid Therapeutics
Volume: 25
Issue: 5
Pages: 245-253
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
-
[Journal Article] Photoresponsive DNA Nanocapsule Having an Open/Close System for Capture and Release of Nanomaterials2014
Author(s)
Takenaka, T.; Endo, M.; Suzuki, Y.; Yang, Y.; Emura, T.; Hidaka, K.; Kato, T.; Mitata, T.; Namba, K.; Sugiyama, H
-
Journal Title
Chemistry - A European Journal
Volume: 20
Issue: 46
Pages: 14951-14954
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
