Does enzymatic activity involve in mitochondrial movement?
| Project/Area Number |
26620135
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bio-related chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
Koshiba Takumi 九州大学, 理学(系)研究科(研究院), 准教授 (70403970)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ミトコンドリア / 酵素活性 / GTPase / メタロプロテアーゼ |
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| Outline of Final Research Achievements |
Mitochondria are dynamic organelles that undergo continuous fusion and fission, and these processes are believe to be essential for physiologic function of organisms. Once their balances become to be disrupted, it has been revealed that much of unexpected influences accumulate on physiologic functions.
Our aims of the project is to elucidate their mystery of the mitochondrial shape, and try to understand the mechanism by a molecular level. In this study, we focused on the role of a mitochondrial GTPase, OPA1 and the regulatory molecule of metalloproteases. We identified that OPA1 processing by the proteases would be an essential process for the maintaining of mitochondrial morphology.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Loss of Miro1-directed retrograde mitochondrial movement results in a novel murine model for neuron disease2014
Author(s)
Nguyen, T.T., Oh, S.S., Weaver, D., Lewandowska, A., Maxfield, D., Schuler, M.H., Smith, N.K., Macfarlane, J., Saunders, G., Palmer, C.A., Debattisti, V., Koshiba, T., Pulst, S., Feldman, E.L., Hajnóczky, G., and Shaw, J.M.
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 111
Issue: 35
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Influenza A virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunity2014
Author(s)
Yoshizumi, T., Ichinohe, T., Sasaki, O., Otera, H., Kawabata, S., Mihara, K., and #Koshiba, T.
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Journal Title
Nature Communications
Volume: 5
Issue: 1
Pages: 4713-4713
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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