Development of ion channel screening array applying CCD ion image sensor
| Project/Area Number |
26630156
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Electron device/Electronic equipment
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| Research Institution | Toyohashi University of Technology |
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Principal Investigator |
Tero Ryugo 豊橋技術科学大学, 工学(系)研究科(研究院), 准教授 (40390679)
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| Co-Investigator(Renkei-kenkyūsha) |
SAWADA Kazuaki 豊橋技術科学大学, 電気・電子情報工学系, 教授 (40235461)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 脂質二重膜 / CCDイオンセンサ / イオン感応膜 |
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| Outline of Final Research Achievements |
Ion channels are one of membrane proteins crucial for the transportation of materials and information into and out of cells, therefore are important target of drug discovery. In this research we aimed to apply semiconductor-based ion imaging sensor (CCD-IIS) which selectively response to a specific cation to the detection of the activity of ion channels, and established the fundamental techniques for this purpose. We fabricated an artificial lipid bilayer membrane on CCD-IIS, and evaluated the structure and physical properties. We measured the ionic response before and after the formation of the bilayer formation using CCD-IIS. The artificial lipid bilayer showed sufficient ion screening effect under the exchange of buffer solutions.
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Report
(3 results)
Research Products
(7 results)
