| Project/Area Number |
26640027
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Research Institute for Clinical Oncology, Saitama Cancer Center |
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Principal Investigator |
Shimaoka Tatsurou 埼玉県立がんセンター(臨床腫瘍研究所), 臨床腫瘍研究所, その他 (10565865)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUSHIMA Yoshibumi 埼玉県立がんセンター, 臨床腫瘍研究所, 研究員 (10094955)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 神経発生 / 分化 / 自然発症変異 / 小頭症 / 疾患モデル |
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| Outline of Final Research Achievements |
(1) Histopathological examination revealed that the growth was extremely delayed in each part of the brain of microcephaly-affected individuals. Cerebral cortex: Layer structure is unclear. In particular, the outer granule layer and the inner granule layer disappeared. Hippocampus: At the hippocampus-dentate gyrus site, formation was extremely immature or disappeared. Cerebellum: There was no cortex on the Purkinje cell layer. Olfactory bulb: Granular cell layer was immature or disappeared.(2) The causative gene was narrowed down to chromosome 5, but the candidate gene could not be determined.(3) Congenic strains to BALB/c and C57BL/6 are underway for the establishment of microcephaly model mice. Balb/c microcephaly mice have been deposited with the RIKEN BioResource Cnter.
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