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The Roles of Dopamine on Prefrontal Cortical Neoteny

Research Project

Project/Area Number 26640044
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Neurochemistry/Neuropharmacology
Research InstitutionKyoto University

Principal Investigator

GOTO YUKIORI  京都大学, 霊長類研究所, 准教授 (10645584)

Research Collaborator LEE YOUNG-A  Catholic University of Daegu, Department of Food Science and Nutrition, Assistant Professor
YAMAGUCHI YOSHIE  京都大学, 霊長類研究所, 大学院生
KATO AKEMI  京都大学, 霊長類研究所, 技術補佐員
OGAWA SHINO  京都大学, 人間環境学研究科, 研究員
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsドーパミン / 前頭前皮質 / 社会認知 / 社会階級 / げっ歯類 / 霊長類 / ストレス / 認知機能 / 前頭前野皮質
Outline of Final Research Achievements

Prefrontal cortex (PFC) is thought to be the center of brain areas that mediates highly complex cognitive functions. However, how the PFC has evolved to acquire such complex brain functions remains unknown. In this study, we investigated the roles of dopamine (DA), one of neurotransmitters employed in the PFC, on social cognition in rodents and non-human primates, who are under social group housing, and elucidated some insights how DA may drive evolution of the PFC-dependent brain functions.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (36 results)

All 2017 2016 2015 2014 Other

All Int'l Joint Research (2 results) Journal Article (13 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 11 results,  Acknowledgement Compliant: 8 results,  Open Access: 6 results) Presentation (21 results) (of which Int'l Joint Research: 6 results,  Invited: 5 results)

  • [Int'l Joint Research] Catholic University of Daegu(韓国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Catholic University of Daegu(韓国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Prefrontal cortical activity associated with visual stimulus categorization in non-human primates measured with near-infrared spectroscopy2017

    • Author(s)
      Lee YA, Pollet P, Kato A, Goto Y
    • Journal Title

      Behavioural Brain Research

      Volume: 317 Pages: 327-331

    • DOI

      10.1016/j.bbr.2016.09.068

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The roles of dopamine D1 receptor on the social hierarchy of rodents and non-human primates2017

    • Author(s)
      Yamaguchi Y, Lee YA, Kato A, Goto Y
    • Journal Title

      International Journal of Neuropsychopharmacology

      Volume: 20(4) Pages: 324-335

    • DOI

      10.1093/ijnp/pyw106

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Associations of acute and chronic stress hormones with cognitive functions in autism spectrum disorder.2017

    • Author(s)
      Ogawa, S., Lee, Y. A., Yamaguchi, Y., Shibata, Y., & Goto, Y.
    • Journal Title

      Neuroscience

      Volume: 343 Pages: 229-239

    • DOI

      10.1016/j.neuroscience.2016.12.003

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dopamine-dependent visual attention preference to social stimuli in non-human primates2017

    • Author(s)
      Yamaguchi Y, Atsumi T, Poirot R, Lee YA, Kato A, Goto Y
    • Journal Title

      Psychopharmacology (Berlin)

      Volume: 234 Issue: 7 Pages: 1113-1120

    • DOI

      10.1007/s00213-017-4544-6

    • NAID

      120006822569

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The roles of dopamine D2 receptor in the social hierarchy of rodents and primates2017

    • Author(s)
      Yamaguchi Y, Lee YA, Kato A, Jas E, Goto Y
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 43348-43348

    • DOI

      10.1038/srep43348

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Cognitive and affective alterations by prenatal and postnatal stress interaction2016

    • Author(s)
      Lee YA, Kim YJ, Goto Y
    • Journal Title

      Physiology & Behavior

      Volume: 165 Pages: 146-153

    • DOI

      10.1016/j.physbeh.2016.07.014

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Biological mechanisms underlying evolutionary origins of psychotic and mood disorders.2016

    • Author(s)
      Goto Y, Lee YA, Yamaguchi Y, Jas E
    • Journal Title

      Neuroscience Research

      Volume: TBD

    • NAID

      120006863506

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Neurodevelopmental plasticity in pre- and postnatal environmental interactions: Implications for psychiatric disorders from an evolutionary perspective.2015

    • Author(s)
      Lee YA, Yamaguchi Y, Goto Y
    • Journal Title

      Neural Plasticity

      Volume: 2015 Pages: 291476-291476

    • DOI

      10.1155/2015/291476

    • NAID

      120005668061

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Dopamine in socioecological and evolutionary perspective: Implications for psychiatric disorders.2015

    • Author(s)
      Yamaguchi Y, Lee YA, Goto Y
    • Journal Title

      Frontiers in Neuroscience

      Volume: 9 Pages: 219-219

    • DOI

      10.3389/fnins.2015.00219

    • NAID

      120005672626

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Prefrontal cortical dopamine in evolutionary perspective2015

    • Author(s)
      Lee YA, Goto Y
    • Journal Title

      Neuroscience Bulletin

      Volume: 31 Issue: 2 Pages: 164-174

    • DOI

      10.1007/s12264-014-1499-z

    • NAID

      120005674640

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chronic stress effects on working memory: association with prefrontal cortical tyrosine hydroxylase2015

    • Author(s)
      Lee YA, Goto Y
    • Journal Title

      Behavioural Brain Research

      Volume: 286 Pages: 122-127

    • DOI

      10.1016/j.bbr.2015.03.007

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increased risk of psychiatric disorders by Toxoplasma Gondii: Symbiosis in evolution of brain function?2015

    • Author(s)
      Lee YA, Yamaguchi Y, Goto Y
    • Journal Title

      生存科学

      Volume: in press

    • Related Report
      2014 Research-status Report
  • [Journal Article] Reconsideration of biological mechanisms of psychiatric disorders with evolutionary perspective2015

    • Author(s)
      Yamaguchi Y, Lee YA, Goto Y
    • Journal Title

      生存科学

      Volume: in press

    • Related Report
      2014 Research-status Report
  • [Presentation] Dopamine and serotonin on social cognition as research targets of human brain stimulation2016

    • Author(s)
      Goto Y
    • Organizer
      10th ICME International Conference on Complex Medical Engineering
    • Place of Presentation
      栃木県総合文化センター(栃木)
    • Year and Date
      2016-08-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The roles of dopamine D1 receptor in rodent social hierarchy2016

    • Author(s)
      Goto Y, Lee YA, Yamaguchi Y, Kato A
    • Organizer
      39th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] The effects of Astragalus membranaceus Bunge leaves in a rodent model of ADHD with neonatal habenula lesion2016

    • Author(s)
      Kim YJ, Goto Y, Lee SH, Lee YA
    • Organizer
      39th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] The effects of Ecklonia Stolonifera Okamura in a rodent model of ADHD with neonatal habenula lesion2016

    • Author(s)
      Lee YA, Jeon SY, Kim YJ, Goto Y, Choi JS
    • Organizer
      39th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Social function of dopamine D1 receptor in non-human primates2016

    • Author(s)
      Goto Y, Yamaguchi Y, Lee YA, Kato A
    • Organizer
      30th CINP World Congress of Neuropsychopharmacology
    • Place of Presentation
      Seoul (South Korea)
    • Year and Date
      2016-07-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Potential therapeutic effects of Astragalus membranaceus Bunge leaves on ADHD: a study with neonatal habenula lesion model of ADHD in rats2016

    • Author(s)
      Kim Y, Goto Y, Lee SH, Lee YA
    • Organizer
      46th Annual Meeting of the Japanese Society of Neuropsychopharmacology
    • Place of Presentation
      Seoul (South Korea)
    • Year and Date
      2016-07-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] The roles of cortico-basal ganglia dopamine on social cognition of rodents and primates: Implications for evolutionary origins of psychiatric disorders2016

    • Author(s)
      Goto Y
    • Organizer
      46th Annual Meeting of the Japanese Society of Neuropsychopharmacology
    • Place of Presentation
      Seoul (South Korea)
    • Year and Date
      2016-07-02
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Dopamine in Social Hierarchy and Evolutionary Origins of Drug Addiction and Other Psychiatric Disorders2016

    • Author(s)
      Goto Y
    • Organizer
      36th European Winter Conference on Brain Research & EBBS Winter Conference
    • Place of Presentation
      Villars sur Ollon, Switzerland
    • Year and Date
      2016-03-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Dopamine D1 receptor signaling in social function of non-human primates.2015

    • Author(s)
      Yamaguchi Y, Lee YA, Kato A, Goto Y
    • Organizer
      4th Congress of Asian College of Neuropsychopharmacology
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2015-11-20
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prenatal stress-induced neurodevelopmental alterations as adaptive strategies for postnatal stress environments.2015

    • Author(s)
      Lee YA, Goto Y
    • Organizer
      4th Congress of Asian College of Neuropsychopharmacology
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2015-11-20
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The role of dopamine D1 receptor in non-human primate society.2015

    • Author(s)
      Yamaguchi Y, Lee YA, Kato A, Goto Y
    • Organizer
      Gordon Research Conference (Catecholamines)
    • Place of Presentation
      Newry, ME, USA
    • Year and Date
      2015-08-09
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Secondary chronic stress-induced cognitive dysfunction in children with autism spectrum disorder.2015

    • Author(s)
      Goto Y, Ogawa S, Lee YA, Yamaguchi Y
    • Organizer
      第38回日本神経科学学会大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Alterations of cognitive and affective function as environmental adaptation revealed by prenatal and postnatal stress interaction.2015

    • Author(s)
      Lee YA, Goto Y
    • Organizer
      第38回日本神経科学学会大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] The effects of Astragalus Membranaceus leaves in memory formation.2015

    • Author(s)
      Kim YJ, Kim MJ, Goto Y, Lee YA
    • Organizer
      第38回日本神経科学学会大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] The role of dopamine D1 receptor in non-human primate society.2015

    • Author(s)
      Yamaguchi Y, Lee YA, Kato A, Goto Y
    • Organizer
      第38回日本神経科学学会大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Development of New Drugs for Psychiatric Disorder Inspired by Zoopharmacognosy2014

    • Author(s)
      Goto Y
    • Organizer
      2014 Fall Annual Convention of Pharmacological Society of Korea
    • Place of Presentation
      Hotel Hyundai, Gyeongju, South Korea
    • Year and Date
      2014-10-23 – 2014-10-24
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Are behavioral alterations caused by attenuated dopamine D1 system really deficits in animal society?2014

    • Author(s)
      Yamaguchi Y, Lee YA, Kato A, Goto Y
    • Organizer
      The Social Brain Conference (FENS-The Brain Prize conference)
    • Place of Presentation
      Moltkes Palace, Copenhagen, Denmark
    • Year and Date
      2014-10-05 – 2014-10-08
    • Related Report
      2014 Research-status Report
  • [Presentation] 注意欠如多動性障害と手綱核活動異常との関連2014

    • Author(s)
      Goto Y
    • Organizer
      第36回日本生物学的精神医学会年会
    • Place of Presentation
      奈良県新公会堂
    • Year and Date
      2014-09-29 – 2014-10-01
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Diosgenin-induced cognitive enhancement in normal mice is mediated by 1,25D3-MARRS2014

    • Author(s)
      Tohda C, Lee YA, Goto Y, Nemere I
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Near-infrared spectroscopy (NIRS) in non-human primates: Toward search of biological markers for neurodevelopmental and psychiatric disorders2014

    • Author(s)
      Lee YA, Goto Y
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Evolutionary psychiatry: Reconsideration of biological mechanisms of psychiatric disorders with evolutionary perspective2014

    • Author(s)
      Goto Y, Lee YA
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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