Generation of induction method of insulin producing cells from mouse liver cells in vivo
| Project/Area Number |
26640049
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Laboratory animal science
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | インスリン / β細胞 / 再生 / ダイレクトリプログラミング / 肝細胞 |
|---|
| Outline of Final Research Achievements |
In order to develop a method that induces insulin-producing cells from the liver cells in living mice, we genarated conditinally over-expressing mice of Pdx1, NeuroD and MafA. Furthermore, We identifed a new factor that enhances the production of insulin from mouse liver cells with Pdx1, NeuroD and MafA. The new factor could enhance insulin transcription approximately 10-fold.
|
Report
(3 results)
Research Products
(6 results)
