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Technical development of transplantation human iPS induced hapatoblast and hepatocyte to mice embryos.

Research Project

Project/Area Number 26640060
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Laboratory animal science
Research InstitutionNiigata University of Health and Welfare

Principal Investigator

MORITA KUNIE  新潟医療福祉大学, 医療技術学部, 助手 (90396440)

Co-Investigator(Kenkyū-buntansha) 笹岡 俊邦  新潟大学, 脳研究所, 教授 (50222005)
小田 佳奈子  新潟大学, 脳研究所, 助教 (60708212)
川村 宏樹  新潟医療福祉大学, 医療技術学部, 准教授 (20333495)
浅井 孝夫  新潟医療福祉大学, 医療技術学部, 講師 (60612736)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordshelpatoblast / iPS / iPS細胞 / 肝機能 / 肝臓移植 / がん化 / ヒト化肝臓マウス / hiPS細胞 / 肝細胞 / 移植 / 免疫不全マウス
Outline of Final Research Achievements

This research has conducrted 4 years, from fiscal year 2013 to 2017. The first year of this research, the research reader had changed the laboratory, from Kumamoto University to Niigata University of Health and Welfare. We were granted human iPS cells fron RIKEN, and we strarted differentiation- induced experiment from iPS cells to hepatocytes. And then, we confirmed differentiation to hepatocytes by means of immunological staining, hepatocyes marker ALB, SERPINA1 and HNF4A.
This achivemnnt would help education and research for unversity students trying to be medical techcologysts, the reseach reader instructed there.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2016

All Presentation (2 results)

  • [Presentation] マウス神経堤細胞の解析によるメラノーマ候補遺伝子の検索2016

    • Author(s)
      森田邦恵
    • Organizer
      日本医学検査学会
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2016-09-03
    • Related Report
      2016 Research-status Report
  • [Presentation] マウスへのヒトiPS細胞由来肝細胞移植の試み2016

    • Author(s)
      森田 邦恵
    • Organizer
      再生医療学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2016-03-19
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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