Dissecting the roles of metabolism in the development of cancer by means of the mitochondrial hyperactive model mice
Project/Area Number |
26640082
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Tumor biology
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Research Institution | Nagasaki University |
Principal Investigator |
YAMAMOTO Kazuo 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (70255123)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | ミトコンドリア / トランスジェニックマウス / 白血病 / リンパ腫 / 代謝 |
Outline of Final Research Achievements |
To investigate the roles of metabolism in cancer development, leukemia model mice and mitochondrial hyperactive transgenic mice were analyzed. Mitochondrial hyperactivation resulted in significant extension of the death caused by leukemia. The key protein responsible for this phenomenon was turned out to localize as dots in cytoplasm any other than mitochondria, the Golgi body, endoplasmic reticulum, peroxisome, nor endosome. Transcriptome analysis revealed that a few specific transcription factors governed the unique transcription profile in the cells overexpressing this protein. As the protein synthesis was upregulated in these cells, the effect induced by this protein was analyzed in vivo. The result suggested that the rate of protein synthesis was raised by mitochondrial hyperactivation.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP+/NADPH ratio2015
Author(s)
M Itsumi, S Inoue, AJ Elia, K Murakami, M Sasaki, EF Lind, D Brenner, IS Harris, IIC Chio, S Afzal, RA Cairns, DW Cescon, AR Elford, J Ye, PA Lang, WY Li, A Wakeham, GS Duncan, J Haight, A You-Ten, B Snow, K Yamamoto, PS Ohashi, TW Mak
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Journal Title
Cell Death & Differentiation
Volume: 22
Issue: 11
Pages: 1837-1845
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression2015
Author(s)
Harris IS, Treloar AE, Inoue S, Sasaki M, Gorrini C, Lee KC, Yung KY, Brenner D, Knobbe-Thomsen CB, Cox MA, Elia A, Berger T, Cescon DW, Adeoye A, Brüstle A, Molyneux SD, Mason JM, Li WY, Yamamoto K, Wakeham A, Berman HK, Khokha R, Done SJ, Kavanagh TJ, Lam CW, Mak TW.
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Journal Title
Cancer Cell
Volume: 27
Issue: 2
Pages: 211-222
DOI
Related Report
Peer Reviewed
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