Raft-like structures in the ER: Implication of apoptosis, autophagy, and lipid droplet formation
| Project/Area Number |
26650066
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
TAGAYA MITSUO 東京薬科大学, 生命科学部, 教授 (30179569)
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| Co-Investigator(Kenkyū-buntansha) |
TANI Katsuko 東京薬科大学, 生命科学部, 教授 (40266896)
若菜 裕一 東京薬科大学, 生命科学部, 助教 (90635187)
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| Co-Investigator(Renkei-kenkyūsha) |
WAKANA Yuichi 東京薬科大学, 生命科学部, 助教 (90635187)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 小胞体 / ラフト / syntaxin17 / オートファジー / 脂肪滴 / VAP-A/B |
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| Outline of Final Research Achievements |
The MAM（mitochondria-associated membrane）and some of the other ER subdomains appear to have raft-like structures. In the present project we made the following findings about raft-localized proteins, syntaxin 17 (Syn17) and VAP-A/B: (1) Syn17 regulates apoptosis. (2) Upon nutrient deprivation, Syn17 redistributes from the raft-like structure (MAM) to the non-raft-like structure (autophagosomes).(3) Syn17 in cooperation with another raft-localized protein, SNAP23, regulates lipid droplet formation. (4) VAP-A/B localize to the ER-Golgi contact site and regulate the raft-like structure of the trans-Golgi network.
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Report
(3 results)
Research Products
(7 results)
