Elucidation of mechanisms that regulate neural generation spatio-temporally in the brain using living embryos
| Project/Area Number |
26650077
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Developmental biology
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SATO Fuminori 京都大学, 健康長寿社会の総合医療開発ユニット, 特定助教 (10588263)
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 発生・分化 / 組織・細胞 / 再生医学 / 生体分子 / 細胞・組織 / 細胞分化 / 増殖因子 / 神経分化 / ゼブラフィッシュ / ライブイメージング / ニューレグリン / ErbB |
|---|
| Outline of Final Research Achievements |
Post-mitotic neurons are generated from neural progenitor cells (NPCs) at the expense of their proliferation. Live imaging revealed how production of post-mitotic neurons from neural progenitor cells is regulated in the sub-ventricular zone (SVZ). This neurogenesis depends on Neuregulin 1 type II (NRG1-II)-ErbB signaling. Moreover, we developed a novel fluorescent probe, which enables us to monitor the activity of the NRG1 ecotodomain shedding. Expression of the probe in zebrafish embryos revealed involvement of the NRG1 ecotodmain shedding in the spatio-temporal regulations of its signaling,.
|
Report
(3 results)
Research Products
(27 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] What can we learn by exploring the interstitial space of skeletal muscle during development and regeneration?2015
Author(s)
Sato F, Nishimura D, Hori S, Arai H, Hiramuki Y, Sogabe M, Kuriki M, Choi M, Wang Z, Kawahara A, Kawakami K, Sehara-Fujisawa A.
Organizer
48th Annual meeting of the Japanese Society of Developmental Biologists
Place of Presentation
つくば国際会議場（茨城県つくば市）
Year and Date
2015-06-05
Related Report
-
-
-
-
-
-
[Presentation] Mechanisms of Skeletal Muscle Regeneration2014
Author(s)
Atsuko Sehara-Fujisawa
Organizer
Symposium “Genomic and epigenomic insights into vertebrate regeneration, development and evolustion - development and evolution - Xenopus and fish as models”
Place of Presentation
Pontificia Universidad Catolica de Chile（チリ・カトリカ大学）
Year and Date
2014-11-05
Related Report
Invited
-
-
-
-
-
