Development of Drosophila cell culture system to analyze cell chirality

Research Project

Project/Area Number	26650081
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Developmental biology
Research Institution	Osaka University
Principal Investigator	Matsuno Kenji 大阪大学, 理学(系)研究科(研究院), 教授 (60318227)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	細胞キラリティ / 細胞極性 / 左右非対称性 / 中心体 / ヘモサイト / 発生・分化 / 細胞・組織 / I型ミオシン / ショウジョウバエ
Outline of Final Research Achievements	Chirality of cell structure is observed in vivo in Drosophila. However, bio-imaging analysis of cell chirality found in these cells has been difficult in vivo. Therefore, molecular mechanisms of cell chirality formation are still elusive. To overcome this problem, we attempted to develop a cell culture system to detect cell chirality. In this study, we developed a system to observe the chiral behavior of centrosome in cultured cells.

Report

(3 results)