Screening of natural products for novel mannose-binding agents
| Project/Area Number |
26660099
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioorganic chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
Nakagawa Yu 名古屋大学, 生命農学研究科, 准教授 (90452284)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 天然物 / 糖鎖 / pradimicin / 糖結合性分子 / レクチン / スクリーニング / pradimicin A |
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| Outline of Final Research Achievements |
In an attempt to discover new natural products with D-mannose (Man)-binding ability, we have developed two screening methods using pradimicin A, a Man-binding antibiotic, and oligomannose-attached magnetic beads. Additionally, during the process to prepare a natural product library for the screening, we isolated a new natural product, named quinocidin, with cytotoxicity against HeLa-S3 cells derived from human cervix adenocarcinoma. Structural elucidation revealed that quinocidin possesses a 3,4-dihydroquinolizinium skeleton, which has very rarely been observed in natural products.
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Report
(4 results)
Research Products
(7 results)
