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Screening of natural products for novel mannose-binding agents

Research Project

Project/Area Number 26660099
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Bioorganic chemistry
Research InstitutionNagoya University

Principal Investigator

Nakagawa Yu  名古屋大学, 生命農学研究科, 准教授 (90452284)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords天然物 / 糖鎖 / pradimicin / 糖結合性分子 / レクチン / スクリーニング / pradimicin A
Outline of Final Research Achievements

In an attempt to discover new natural products with D-mannose (Man)-binding ability, we have developed two screening methods using pradimicin A, a Man-binding antibiotic, and oligomannose-attached magnetic beads. Additionally, during the process to prepare a natural product library for the screening, we isolated a new natural product, named quinocidin, with cytotoxicity against HeLa-S3 cells derived from human cervix adenocarcinoma. Structural elucidation revealed that quinocidin possesses a 3,4-dihydroquinolizinium skeleton, which has very rarely been observed in natural products.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (7 results)

All 2017 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] Solid-State Nuclear Magnetic Resonance Analysis Reveals a Possible Calcium Binding Site of Pradimicin A2017

    • Author(s)
      Doi, T., Nakagawa, Y., Takegoshi, K.
    • Journal Title

      Biochemistry

      Volume: 56 Issue: 3 Pages: 468-472

    • DOI

      10.1021/acs.biochem.6b01300

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 第3の生命鎖・糖鎖に結合する低分子化合物に関する現状と展望2014

    • Author(s)
      中川 優
    • Journal Title

      ファルマシア

      Volume: 50 Pages: 1117-1122

    • NAID

      130005265994

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 3,4-Dihydroquinolizinium環を有する新規天然物の単離, 合成および生物活性評価2017

    • Author(s)
      澤木裕紀, 中川 優, 木村高啓, 戸村友彦, 小鹿 一
    • Organizer
      第111回有機合成シンポジウム
    • Place of Presentation
      岡山
    • Year and Date
      2017-06-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] 糖鎖結合性天然物の探索に向けたオリゴ糖固定磁気ビーズの合成と評価2017

    • Author(s)
      宮西 航,中川 優,小鹿 一
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 3,4-Dihydroquinolizinium環を有する新規天然物の単離,構造決定および生物活性評価2017

    • Author(s)
      澤木裕紀,中川 優,木村高啓,戸村友彦,小鹿 一
    • Organizer
      日本農芸化学会2017年度大会
    • Place of Presentation
      京都
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] マンノース結合性天然物の糖認識機構解析:糖鎖研究への利用を目指して2017

    • Author(s)
      中川 優
    • Organizer
      理研シンポジウム
    • Place of Presentation
      埼玉
    • Year and Date
      2017-01-20
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Book] NMR in Glycoscience and Glycotechnology2017

    • Author(s)
      Nakagawa, Y., Ito, Y.
    • Total Pages
      458
    • Publisher
      Royal Society of Chemistry
    • Related Report
      2016 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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